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Controlling the depth of anesthesia by using extended DMC

Bamdadian, A ; Sharif University of Technology | 2008

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  1. Type of Document: Article
  2. DOI: 10.1109/CIBEC.2008.4786115
  3. Publisher: 2008
  4. Abstract:
  5. Monitoring and controlling the depth of anesthesia is really important, since over dosing and under dosing can be dangerous for the patients. Pharmacokinetic-Pharmacodynamic models vastly used for describing the relationship between input anesthetic agents and output patient endpoint variables. As there is a large variety between the patients so for controlling the depth of anesthesia we need a controller which should be robust enough and also because the anesthesia process is nonlinear and contains time delay, among them all the proposed methods for controlling the depth of anesthesia, model predictive controllers (MPCs) are good choices. Extended dynamic matrix control (EDMC) can be applied to nonlinear process control. In this method, control inputs are determined based on a linear model that approximates the process and is updated during each sampling interval. Science nonlinear relation still exists between the prediction error and the control input, numerical methods are used to solve the optimization problem defined in the method. The results showed that the performance of EDMC with or without presence of the noise and disturbance is better than GPC and also it is more robust. © 2008 IEEE
  6. Keywords:
  7. Anesthesiology ; Anesthetics ; Biomedical engineering ; Delay control systems ; Numerical methods ; Pharmacokinetics ; Anesthesia ; Bispectral index (BIS) ; Control inputs ; Depth of anesthesias ; EDMC ; Extended dynamics ; Linear models ; Model predictive controllers ; Monitoring and controlling ; Non linear relations ; Nonlinear process controls ; Optimization problems ; Prediction errors ; Propofol ; Sampling intervals ; Time- delays ; Process control
  8. Source: 2008 Cairo International Biomedical Engineering Conference, CIBEC 2008, Cairo, 18 December 2008 through 20 December 2008 ; 2008 ; 9781424426959 (ISBN)
  9. URL: https://ieeexplore.ieee.org/document/4786115?arnumber=4786115