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Highly chemoselective reductive amination-coupling by one-pot reaction of aldehydes, HMDS and NaBH4

Azizi, N ; Sharif University of Technology | 2008

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  1. Type of Document: Article
  2. DOI: 10.1016/j.tetlet.2008.09.048
  3. Publisher: 2008
  4. Abstract:
  5. An efficient and highly chemoselective synthesis of symmetrical secondary amines via reductive amination of aldehydes with inexpensive and commercially available HMDS and sodium borohydride in high to quantitative yields is reported. © 2008 Elsevier Ltd. All rights reserved
  6. Keywords:
  7. Aldehyde ; Amine ; Hexamethyldisilazane ; Sodium borohydride ; Unclassified drug ; Amination ; Chemical reaction ; Chemical structure ; One pot synthesis ; Sereochemistry
  8. Source: Tetrahedron Letters ; Volume 49, Issue 47 , 2008 , Pages 6682-6684 ; 00404039 (ISSN)
  9. URL: https://www.sciencedirect.com/science/article/abs/pii/S0040403908017073