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BF3·SiO2: an efficient reagent system for the one-pot synthesis of 1,2,4,5-tetrasubstituted imidazoles

Sadeghi, B ; Sharif University of Technology | 2008

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  1. Type of Document: Article
  2. DOI: 10.1016/j.tetlet.2008.02.100
  3. Publisher: 2008
  4. Abstract:
  5. Silica-supported boron trifluoride (BF3·SiO2) is an efficient, readily available and reusable catalyst for the synthesis of 1,2,4,5-tetrasubstituted imidazoles using benzil, an aromatic aldehyde and an amine in the presence of ammonium acetate. This one-pot procedure is very simple, affording good to excellent yields. © 2008 Elsevier Ltd. All rights reserved
  6. Keywords:
  7. Aldehyde ; amine ; Ammonium acetate ; Benzil ; Boron trifluoride ; Imidazole derivative ; Reagent ; Unclassified drug ; Catalyst ; One pot synthesis ; Substitution reaction
  8. Source: Tetrahedron Letters ; Volume 49, Issue 16 , 2008 , Pages 2575-2577 ; 00404039 (ISSN)
  9. URL: https://www.sciencedirect.com/science/article/abs/pii/S0040403908003298