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A facile aerobic copper-catalyzed α-oxygenation of aryl thioacetamides: An efficient access to α-keto aryl thioamides

Matloubi Moghaddam, F ; Sharif University of Technology | 2008

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  1. Type of Document: Article
  2. DOI: 10.1055/s-2008-1042925
  3. Publisher: 2008
  4. Abstract:
  5. Copper(II) efficiently catalyzes the aerobic oxidation of aryl thioacetamides into the corresponding α-keto aryl thioamides in moderate to high yields in the presence of K2CO3 under O 2 atmosphere. This protocol is simple, clean, and generates water as the only byproduct. A mechanism is proposed for the reaction course. © Georg Thieme Verlag Stuttgart
  6. Keywords:
  7. Acetamide derivative ; Copper ; Oxygen ; Thioamide ; Aerobic metabolism ; Catalysis ; Chemical reaction ; Chemical structure ; Molecular interaction ; Oxygenation ; Reaction analysis ; Structure analysis
  8. Source: Synlett ; Issue 6 , 2008 , Pages 892-896 ; 09365214 (ISSN)
  9. URL: https://www.thieme-connect.com/products/ejournals/abstract/10.1055/s-2008-1042925