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LiClO4-accelerated three-component Mannich-type reaction of diethyl malonate with imines: An efficient synthesis of β-amino esters under solvent-free conditions

Aryanasab, F ; Sharif University of Technology | 2008

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  1. Type of Document: Article
  2. DOI: 10.1080/00397910802271297
  3. Publisher: 2008
  4. Abstract:
  5. LiClO4 is used as catalyst for direct Mannich-type reaction of aryl aldehydes, aryl amines, and diethyl malonic ester under solvent-free conditions. This three-component reaction afforded the corresponding β-amino esters in good yields with simple and environmentally benign procedure. Copyright © Taylor & Francis Group, LLC
  6. Keywords:
  7. Aromatic amine ; Beta amino acid ; Ester derivative ; Imine ; Lithium ; Lithium perchlorate trihydrate ; Malonic acid ; Solvent ; Unclassified drug ; Catalyst ; Chemical reaction ; Mannich reaction ; Synthesis
  8. Source: Synthetic Communications ; Volume 38, Issue 22 , 2008 , Pages 4036-4044 ; 00397911 (ISSN)
  9. URL: https://www.tandfonline.com/doi/abs/10.1080/00397910802271297