Synthesis and properties of biodegradable hydrogels of κ-carrageenan grafted acrylic acid-co-2-acrylamido-2-methylpropanesulfonic acid as candidates for drug delivery systems

Pourjavadi, A ; Sharif University of Technology | 2007

174 Viewed
  1. Type of Document: Article
  2. DOI: 10.1016/j.reactfunctpolym.2007.04.007
  3. Publisher: 2007
  4. Abstract:
  5. Novel types of highly swelling hydrogels were prepared by grafting crosslinked polyacrylic acid-co-poly-2-acrylamido-2-methylpropanesulfonic acid (PAA-co-PAMPS) chains onto κ-carrageenan through a free radical polymerization method. Here, we propose a mechanism for κ-carrageenan-g-PAA-co-PAMPS formation and confirm the hydrogel structure using FTIR spectroscopy. The effect of grafting variables (i.e. concentration of methylenebisacrylamide (MBA), acrylic acid/-2-acrylamido-2-methylpropanesulfonic acid (AA/AMPS) weight ratio, ammonium persulfate (APS), κ-carrageenan, neutralization percent and reaction temperature) were systematically optimized to achieve a hydrogel with a maximum swelling capacity. The maximum water absorbency of the optimized final product was 1238 g/g, while poly-2-acrylamido-2-methylpropanesulfonic acid-g-κ-carrageenan and polyacrylic acid-g-κ-carrageenan hydrogels swelled to a range of 135-800 g/g. The swelling of superabsorbent hydrogels was measured in various solutions with pH values ranging from 1 to 13. In addition, the pH reversibility, on-off switching behavior and swelling kinetics in distilled water were preliminarily investigated. © 2007 Elsevier Ltd. All rights reserved
  6. Keywords:
  7. Biodegradable polymers ; Grafting (chemical) ; pH effects ; Swelling ; Ammonium persulfate (APS) ; Polyacrylic acid ; Superabsorbent ; Weight ratio ; Hydrogels
  8. Source: Reactive and Functional Polymers ; Volume 67, Issue 7 , 2007 , Pages 644-654 ; 13815148 (ISSN)
  9. URL: https://www.sciencedirect.com/science/article/abs/pii/S1381514807000739