Fabrication of Composite Electrode Materials Based on Bi-Metalic Metal-Organic Frameworks for Designation of Amperometric Non-Enzymatic Glucose Sensors

Ataei Kachouei, Matin | 2021

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  1. Type of Document: M.Sc. Thesis
  2. Language: Farsi
  3. Document No: 54277 (03)
  4. University: Sharif University of Technology
  5. Department: Chemistry
  6. Advisor(s): Shahrokhian, Saeed
  7. Abstract:
  8. In the present study, the method of direct growth was used to grew bi-metalic MOFs based on cobalt and zinc, as electroactive centers, for preparing electrochemical sensors for the determination of glucose. In comparison to most of the electrochemical sensing platforms based on MOFs for determining glucose, which suffer from some disadvantages like time-consuming synthesis procedures and using hazardous organic solvents, the proposed in-situ growth method is much faster and without any need to toxic organic solvents. Herein, cobalt and zinc-based MOFs were grown on the surface of glassy carbon electrode by the direct and rapid conversion of layered double hydroxide nanosheets intermediates. The electrochemical behavior of the as prepared MOFs via in-situ method toward glucose electro-oxidation was evaluated. The results show that the modified electrode via in-situ based MOFs show better electrochemical responses against electrooxidation of glucose, which can be attributed to uniform structure of these MOFs and better accessibility of the electrolyte ions and analyte molecules to the surface of the electrode. The capability of the in-situ based MOFs modified electrode for quantitative determination of glucose was evaluated via amperometry technique. Finally, in order to examine the ability of the modified electrode in practical applications, the human blood serum, urine and saliva samples were analyzed and results show that the fabricated electrode can be used as a reliable and applicable sensing platform for the determination of glucose in physiological samples
  9. Keywords:
  10. Glassy Carbon Electrode ; Glucose Sensor ; Modified Electrodes ; Layered Double Hydroxide (LDH) ; Metal-Organic Framework ; Nonenzymatic Sensor

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