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Stereoselective synthesis of β-amino ketones via direct Mannich-type reactions, catalyzed with ZrOCl2·8H2O under solvent-free conditions

Eftekhari-Sis, B ; Sharif University of Technology | 2006

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  1. Type of Document: Article
  2. DOI: 10.1002/ejoc.200600493
  3. Publisher: 2006
  4. Abstract:
  5. At room temperature, zirconium oxychloride (ZrOCl2· 8H2O) efficiently catalyzes the direct Mannich-type reaction of a variety of in situ generated aldimines using aldehydes and anilines with ketones in a three-component reaction under solvent-free conditions. The reaction proceeds rapidly and affords the corresponding β-amino ketones in good to high yields with good to excellent stereoselectivities. The catalyst can be recycled for subsequent reactions without any appreciable loss of efficiency. © Wiley-VCH Verlag GmbH & Co. KGaA, 2006
  6. Keywords:
  7. β-amino ketones ; Direct Mannich-type reaction ; Solvent-free conditions ; Zirconium oxychloride
  8. Source: European Journal of Organic Chemistry ; Issue 22 , 2006 , Pages 5152-5157 ; 1434193X (ISSN)
  9. URL: https://chemistry-europe.onlinelibrary.wiley.com/doi/10.1002/ejoc.200600493