Constructing and Investigation of the Electrochemical Behavior of Nanocomposite of Conducting Polymers on Copper Hydroxide Nanotubes; Application to Determination of Glucose

Manafi, Reza | 2021

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  1. Type of Document: M.Sc. Thesis
  2. Language: Farsi
  3. Document No: 54463 (03)
  4. University: Sharif University of Technology
  5. Department: Chemistry
  6. Advisor(s): Shahrokhian, Saeed
  7. Abstract:
  8. A novel amperometric non-enzymatic glucose (NEG) sensor is designed by a facile preparation method. It is made by electrodeposition of Cu clusters and converting them to Cu(OH)2 nanotubes (Cu(OH)2NTs) arrays along with thin-film electro-polymerized of spindle-shaped polypyrrole (PPy@Cu(OH)2NTs), which have been doped by using sodium Benzene-1,3- disulfonate as an anion dopant. The electrochemical performance of the modified electrode toward glucose detection is investigated by various electrochemical methods. Under the optimized conditions, a significant electrochemical response improvement is observed toward the electro-oxidation of glucose on the surface of PPy@Cu(OH)2NTs electrode relative to the Cu(OH)2NTs and the bare glassy carbon electrode. The designed electrode demonstrated an acceptable linear dynamic range in two wide ranges of 1 µM - 1.78 mM and 1.78 mM – 6.53 mM with high sensitivities of 910 µA mM-1 cm-2 and 675 µA mM-1 cm-2, respectively. The results are shown a low detection limit of 0.35 µM. Besides high sensitivity, this sensor represented good reproducibility and repeatability for glucose analysis, and also provided suitable results for the NEG determination in clinical preparations. This system is also exhibit highly selectivity for glucose oxidation that almost no signal was detected from interferences such as ascorbic acid, dopamine, uric acid, and chloride ions, demonstrating its great potential as a non-enzymatic glucose sensor. The superb sensing performance is ascribed to the sufficient catalytic sites of scroll-like Cu(OH)2NTs arrays morphology and synergistic effect of the doped-polypyrrole, which improve the surface area and act as a conductive binder on the electrode surface
  9. Keywords:
  10. Modified Electrodes ; Polypyrrole ; Electropolymerization ; Nonenzymatic Sensor ; Glassy Carbon Electrode ; Copper Hydroxide Nanotubes ; Electrochemical Behavior ; Glucose Measurment

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