Cytochrome 4Z1 expression is associated with unfavorable survival in triple-negative breast cancers

Al Saraireh, Y. M ; Sharif University of Technology | 2021

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  1. Type of Document: Article
  2. DOI: 10.2147/BCTT.S329770
  3. Publisher: Dove Medical Press Ltd , 2021
  4. Abstract:
  5. Purpose: Triple-negative breast cancer (TNBC) is characterized by high mortality rate, and its clinical management is difficult and complex. Therefore, there is a need for extensive efforts aimed at accelerating the discovery of novel therapies for TNBC. CYP4Z1 has been implicated in the development of breast cancer. The current study aimed at characterizing the expression of CYP4Z1 on TNBC. Materials and Methods: Using immunohistochemistry, CYP4Z1 expression was evaluated on 122 TNBC samples, four samples of breast cancers expressing ER, PR, and HER-2, and four samples of normal breast tissues. The association between the enzyme and various histopathological features and survival of patients were determined. Results: CYP4Z1 was strongly expressed in 83.3% of various histopathological subtypes of TNBC, when compared to negative expression in normal breast tissues. Interestingly, there were marked variations in CYP4Z1 expression with respect to histopathology subtype, histological grade, histological stage and tumor diameter. There was a high incidence of CYP4Z1 expression in patients with advanced grades, late stages and larger tumor sizes. Importantly, CYP4Z1 expression was correlated with the survival of TNBC patients, but it was an independent determinant of the poor prognosis of TNBC (p< 0.05). Conclusion: CYP4ZI may be a potential biomarker or target for evolving new CYP4Z1-targeted treatments. © 2021 Al-saraireh et al
  6. Keywords:
  7. Biological marker ; Cytochrome P450 4Z1 ; Cytochrome P450 family 4 ; Epidermal growth factor receptor 2 ; Estrogen ; Progesterone ; Unclassified drug ; Adult ; Apocrine carcinoma ; Breast tissue ; Cancer grading ; Cancer prognosis ; Cancer staging ; Cancer survival ; Carcinoid ; Colloid carcinoma ; Controlled study ; Distant metastasis ; Ductal carcinoma ; Female ; Histopathology ; Human ; Human cell ; Human tissue ; Immunohistochemistry ; Invasive carcinoma ; Lobular carcinoma ; Major clinical study ; Medullary carcinoma ; Middle aged ; Neuroendocrine carcinoma ; Overall survival ; Papillary carcinoma ; Protein expression ; Scoring system ; Triple negative breast cancer ; Tumor volume
  8. Source: Breast Cancer: Targets and Therapy ; Volume 13 , 2021 , Pages 565-574 ; 11791314 (ISSN)
  9. URL: https://www.dovepress.com/cytochrome-4z1-expression-is-associated-with-unfavorable-survival-in-t-peer-reviewed-fulltext-article-BCTT#