Glypican-1 overexpression in different types of breast cancers

Alshammari, F. O. F. O ; Sharif University of Technology | 2021

490 Viewed
  1. Type of Document: Article
  2. DOI: 10.2147/OTT.S315200
  3. Publisher: Dove Medical Press Ltd , 2021
  4. Abstract:
  5. Purpose: Treatment of metastatic breast cancer patients is challenging and remains a major underlying cause of female mortality. Understanding molecular alterations in tumor development is critical to identify novel biomarkers and targets for cancer diagnosis and therapy. One of the aberrant cancer expressions gaining recent research interest is glypican-1. Several studies reported strong glypican-1 expression in various types of human cancers. However, none of these investigated glypican-1 expression in a large cohort of breast cancer histopathological subtypes. Patients and Methods: Immunohistochemistry was used to assess glypican-1 expression in 220 breast cancer patients and its relation to demographic and clinical features, as well as important prognostic immunohistochemical markers for breast cancer. Results: Intense glypican-1 expression was recognized in all breast cancer histopathological subtypes. Normal, healthy breast tissue displayed a heterogeneous low expression (20%). Importantly, a strong differential in glypican-1 expression was determined between normal and malignant breast tissues. Moreover, there was a significantly high rate of glypican-1 expression in advanced grades of breast cancer patients and larger tumor sizes. Unfortunately, the glypican-1 expression demonstrated no obvious relationship with the expression of various biomarkers in breast cancer. Conclusion: This study may establish glypican-1 as a promising new therapeutic target for the development of therapy in breast cancer. © 2021 Alshammari et al
  6. Keywords:
  7. Androgen receptor ; Biological marker ; Epidermal growth factor receptor ; Epidermal growth factor receptor 2 ; Estrogen receptor ; Glypican 1 ; Monoclonal antibody Ki 67 ; Progesterone receptor ; Protein p53 ; Adenoid cystic carcinoma ; Adult ; Anaplastic carcinoma ; Apocrine carcinoma ; Breast cancer ; Breast carcinoma ; Cancer grading ; Cancer staging ; Clinical feature ; Cohort analysis ; Controlled study ; Demography ; Disease marker ; Female ; Histopathology ; Human ; Human tissue ; Immunohistochemistry ; Immunoreactivity ; Intraductal carcinoma ; Lobular carcinoma ; Lymph node metastasis ; Major clinical study ; Paget nipple disease ; Papillary carcinoma ; Protein analysis ; Protein expression ; Tumor volume
  8. Source: OncoTargets and Therapy ; Volume 14 , 2021 , Pages 4309-4318 ; 11786930 (ISSN)
  9. URL: https://www.dovepress.com/glypican-1-overexpression-in-different-types-of-breast-cancers-peer-reviewed-fulltext-article-OTT