Drug delivery performance of nanocarriers based on adhesion and interaction for abdominal aortic aneurysm treatment

Ebrahimi, S ; Sharif University of Technology | 2021

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  1. Type of Document: Article
  2. DOI: 10.1016/j.ijpharm.2020.120153
  3. Publisher: Elsevier B.V , 2021
  4. Abstract:
  5. Targeted drug delivery using nanocarriers (NCs) is one of the novel techniques that has recently been used to improve drug delivery to the Abdominal aortic aneurysm (AAA) disease. The purpose of this study is to evaluate the surface density of NCs (SDNC) adhered via ligand-receptor binding to the inner wall of AAA. For this purpose, fluid–structure interaction (FSI) analysis was first performed for the patient-specific and ideal AAA models. Then, by injecting NCs into the aortic artery, the values of SDNC adhered to and interacted with AAA wall were obtained. Two types of NCs, liposomes, and solid particles in four different diameters, were used to investigate the effect of the diameter and the type of NCs on the drug delivery. Additionally, the effect of the number of the injected NCs to the artery on the values of SDNC adhered to and interacted with AAA wall was investigated. The simulation results showed that the interaction and adhesion values of SDNC for Liposome nanoparticles were higher than the ones for the solid particles. Furthermore, as the diameter of NCs increases, the values of SDNC adhered to AAA wall increase, but the values of SDNC interacted with the inner wall of AAA decrease. In the low number of inserted NCs in the artery (1000 NCs), the interaction and adhesion values of SDNC were very slight, and by increasing the number of NCs inserted into the artery, the drug delivery was improved. By examining different AAA models, it was found that the complexity of the shape of AAA has a minor effect on the pattern of increase or decrease of the values of SDNC adhered to and interacted with AAA wall. This study's findings can improve the understanding of NCs design and propose the appropriate amount of their injection into various AAA models. © 2020 Elsevier B.V
  6. Keywords:
  7. Liposome ; Nanocarrier ; Nanoparticle ; Drug ; Abdominal aortic aneurysm ; Adhesion ; Aortic wall ; Artery wall ; Association constant ; Blood flow ; Fluid flow ; Geometry ; Injection ; Ligand binding ; Microbubble ; Priority journal ; Receptor binding ; Simulation ; Biological model ; Drug delivery system ; Human ; Aortic Aneurysm, Abdominal ; Computer Simulation ; Drug Delivery Systems ; Humans ; Models, Cardiovascular ; Pharmaceutical Preparations
  8. Source: International Journal of Pharmaceutics ; Volume 594 , 2021 ; 03785173 (ISSN)
  9. URL: https://pubmed.ncbi.nlm.nih.gov/33301866