Development of an electrochemical sensor based on (rGO-CNT) nanocomposite for raloxifene analysis

Ghalkhani, M ; Sharif University of Technology | 2021

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  1. Type of Document: Article
  2. DOI: 10.1016/j.matchemphys.2020.124131
  3. Publisher: Elsevier Ltd , 2021
  4. Abstract:
  5. A novel modified electrode is reported for the electrochemical investigation of the oxidation mechanism and also voltammetric determination of raloxifene (RLX). The surface of the electrode was modified with a thin layer of reduced graphene oxide-carbon nanotube nano-composite (rGO-CNT) was prepared, and successfully employed for the electrochemical studies of RLX. The morphology of the sensor surface was characterized by using a scanning electron microscopy. RLX Oxidation response significantly increased at the GCE covered with rGO-CNT, regarding the bare and CNT or rGO functionalized GCE. Experimental parameters affecting the RLX response were optimized and mechanism of the RLX oxidation at rGO-CNT/GCE was investigated. The results showed that RLX is oxidized to a reactive phenoxyl radical and its oxidation product participates in an electrochemical reversible reaction. Relation between concentration and peak current of RLX was linear at two ranges of 0.006–5.0 and 5.0–15.0 μM and limit of detection 2 nM was obtained. Capability of rGO-CNT/GCE for measurement of RLX in blood plasma and pharmaceutical samples was evaluated, which demonstrated usability of the rGO-CNT/GCE for accurate RLX analysis in various samples. © 2020
  6. Keywords:
  7. Blood ; Electrochemical sensors ; Glass membrane electrodes ; Graphene ; Morphology ; Oxidation ; Reduced Graphene Oxide ; Scanning electron microscopy ; Electrochemical investigations ; Electrochemical studies ; Experimental parameters ; Limit of detection ; Modified electrodes ; Oxidation mechanisms ; Reversible reaction ; Voltammetric determination ; Carbon nanotubes
  8. Source: Materials Chemistry and Physics ; Volume 263 , 2021 ; 02540584 (ISSN)
  9. URL: https://www.sciencedirect.com/science/article/abs/pii/S0254058420314917