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Healthy and diseasedin vitromodels of vascular systems

Hosseini, V ; Sharif University of Technology | 2021

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  1. Type of Document: Article
  2. DOI: 10.1039/d0lc00464b
  3. Publisher: Royal Society of Chemistry , 2021
  4. Abstract:
  5. Irregular hemodynamics affects the progression of various vascular diseases, such atherosclerosis or aneurysms. Despite the extensive hemodynamics studies on animal models, the inter-species differences between humans and animals hamper the translation of such findings. Recent advances in vascular tissue engineering and the suitability ofin vitromodels for interim analysis have increased the use ofin vitrohuman vascular tissue models. Although the effect of flow on endothelial cell (EC) pathophysiology and EC-flow interactions have been vastly studied in two-dimensional systems, they cannot be used to understand the effect of other micro- and macro-environmental parameters associated with vessel wall diseases. To generate an idealin vitromodel of the vascular system, essential criteria should be included: 1) the presence of smooth muscle cells or perivascular cells underneath an EC monolayer, 2) an elastic mechanical response of tissue to pulsatile flow pressure, 3) flow conditions that accurately mimic the hemodynamics of diseases, and 4) geometrical features required for pathophysiological flow. In this paper, we review currently availablein vitromodels that include flow dynamics and discuss studies that have tried to address the criteria mentioned above. Finally, we critically reviewin vitrofluidic models of atherosclerosis, aneurysm, and thrombosis. © The Royal Society of Chemistry 2021
  6. Keywords:
  7. Animals ; Endothelial cells ; Muscle ; Tissue engineering ; Environmental parameter ; Geometrical features ; Interim analysis ; Mechanical response ; Pathophysiological ; Smooth muscle cells ; Two-dimensional systems ; Vascular tissue engineering ; Diseases ; Aneurysm ; Blood vessel wall ; Cardiovascular disease ; Cardiovascular system ; Cell culture ; Clinical feature ; Coculture ; Elasticity ; Human ; In vitro study ; Microfluidics ; Nanofluidics ; Nonhuman ; Pathophysiology ; Perivascular cell ; Priority journal ; Pulsatile flow ; Smooth muscle cell ; Thrombosis ; Vascular smooth muscle cell ; Vascular tissue ; Animal ; Biological model ; Endothelium cell ; Atherosclerosis ; Hemodynamics ; Humans ; Models, Cardiovascular ; Myocytes, Smooth Muscle
  8. Source: Lab on a Chip ; Volume 21, Issue 4 , 2021 , Pages 641-659 ; 14730197 (ISSN)
  9. URL: https://pubs.rsc.org/en/content/articlelanding/2021/lc/d0lc00464b