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Nano cobalt-copper ferrite catalyzed regioselective α-C(sp3)–H cyanation of amines: Secondary, tertiary, and drug molecules

Matloubi Moghaddam, F ; Sharif University of Technology | 2021

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  1. Type of Document: Article
  2. DOI: 10.1016/j.catcom.2020.106211
  3. Publisher: Elsevier B.V , 2021
  4. Abstract:
  5. Oxidative cyanation of sp3C–H bonds at the α position of amines was achieved using CoCuFe2O4 as a catalyst and NaCN as an inexpensive cyanide source at room temperature. CoCuFe2O4 was found to be an active catalyst for Csp [3]-Csp coupling, efficiently delivering valuable α-aminonitriles from tertiary/secondary amines in good yields. The corresponding products were obtained with high selectivity toward α position. In addition, functional group tolerance offered the opportunity for application in late-stage functionalization of biologically active molecules. This transformation proceeds convenient on a gram-scale, and the catalyst can be reused for several runs with consistent catalytic activity. © 2020
  6. Keywords:
  7. Amines ; Catalyst activity ; Cobalt ; Cobalt compounds ; Copper ; Copper alloys ; Ferrite ; Iron compounds ; Magnetic materials ; Molecules ; Sodium compounds ; Active catalyst ; Biologically active molecules ; Cobalt-copper ; Drug molecules ; Functionalizations ; High selectivity ; Oxidative cyanation ; Regio-selective ; Copper compounds
  8. Source: Catalysis Communications ; Volume 149 , 2021 ; 15667367 (ISSN)
  9. URL: https://www.sciencedirect.com/science/article/pii/S1566736720302879#!