Emerging phospholipid nanobiomaterials for biomedical applications to lab-on-a-chip, drug delivery, and cellular engineering

Rahimnejad, M ; Sharif University of Technology | 2021

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  1. Type of Document: Article
  2. DOI: 10.1021/acsabm.1c00932
  3. Publisher: American Chemical Society , 2021
  4. Abstract:
  5. The design of advanced nanobiomaterials to improve analytical accuracy and therapeutic efficacy has become an important prerequisite for the development of innovative nanomedicines. Recently, phospholipid nanobiomaterials including 2-methacryloyloxyethyl phosphorylcholine (MPC) have attracted great attention with remarkable characteristics such as resistance to nonspecific protein adsorption and cell adhesion for various biomedical applications. Despite many recent reports, there is a lack of comprehensive review on the phospholipid nanobiomaterials from synthesis to diagnostic and therapeutic applications. Here, we review the synthesis and characterization of phospholipid nanobiomaterials focusing on MPC polymers and highlight their attractive potentials for applications in micro/nanofabricated fluidic devices, biosensors, lab-on-a-chip, drug delivery systems (DDSs), COVID-19 potential usages for early diagnosis and even treatment, and artificial extracellular matrix scaffolds for cellular engineering. ©
  6. Keywords:
  7. Cell adhesion ; Cell engineering ; Controlled drug delivery ; Functional polymers ; Lab-on-a-chip ; Medical applications ; Phospholipids ; Scaffolds ; Scaffolds (biology) ; Targeted drug delivery ; 2-methacryloyloxyethyl phosphorylcholine ; Adsorption/adhesion ; Biomedical applications ; Cells adhesion ; Cellular engineering ; Diagnostic applications ; Nanobiomaterials ; Non-specific protein adsorption ; Therapeutic Application ; Therapeutic efficacy ; Diagnosis
  8. Source: ACS Applied Bio Materials ; 2021 ; 25766422 (ISSN)
  9. URL: https://pubs.acs.org/doi/abs/10.1021/acsabm.1c00932