Voltammetric studies of propylthiouracil at a carbon-paste electrode modified with cobalt(II)-4-chlorosalophen: Application to voltammetric determination in pharmaceutical and clinical preparations

Shahrokhian, S ; Sharif University of Technology | 2005

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  1. Type of Document: Article
  2. DOI: 10.1007/s00604-005-0382-z
  3. Publisher: 2005
  4. Abstract:
  5. A carbon-paste electrode chemically modified with a Schiff-base complex of cobalt (cobalt(II)-4-chlorosalophen, CoClSal) is utilized to investigate the voltammetric response of propylthiouracil (PTU). The mechanism of electrocatalytic oxidation of the compound is investigated by means of cyclic voltammetric studies applying various pHs to the buffered solutions. The modified electrode exhibits effective catalytic properties that lower the anodic overpotential and enhance the rate of electron transfer for the electrochemical oxidation of PTU. The results of the cyclic voltammetric (CV) and differential pulse voltammetric (DPV) techniques showed that the modified electrode exhibits good selectivity for discriminating between the anodic wave of PTU and some biological thiols (e.g. cysteine) which may be present in human serum samples. DPV is used as a very sensitive electroanalytical method for the detection of trace amounts of PTU in pharmaceutical and clinical preparations. The results showed that the anodic peak current for the analyte in DPV varies linearly with the concentration of PTU in the range of 7.5 × 10-6 to 7.5 × 10-4 M (RSD for the slope of calibration curve <4%, n = 6). © Springer-Verlag 2005
  6. Keywords:
  7. Carbon paste electrode ; Propylthiouracil ; Differential pulse voltammetry ; Cyclic voltammetry ; Cobalt(II)-4- chlorosalophen ; Chemically modified electrodes
  8. Source: Microchimica Acta ; Volume 151, Issue 1-2 , 2005 , Pages 73-79 ; 00263672 (ISSN)
  9. URL: https://link.springer.com/article/10.1007/s00604-005-0382-z