Modeling and Analysis of Interaction between Tairlored CNT-Graphene Scaffolds and Stem Cell Growth and Differentitation

Shoghmand Nazarloo, Ahad | 2022

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  1. Type of Document: Ph.D. Dissertation
  2. Language: Farsi
  3. Document No: 55084 (08)
  4. University: Sharif University of Technology
  5. Department: Mechanical Engineering
  6. Advisor(s): Ahmadian, Mohammad Taghi; Firoozbakhsh, Kheikhosrow
  7. Abstract:
  8. Since its successful synthesis as single layer during the past decades, Graphene and its derivatives have been extensively employed by many researchers in various science and engineering fields. The studies to characterize and define graphene behaviour are still in demand to answer the questions around these structures. The unique feathures of graphene such as high strength, good conductivity, large available surface, intoxicity and biocompatibility, has made it a suitable candidate to used in novel structures and materials. In this work, hybrid structures made from graphene and carbon nanotubes are investigated which can be utilized as scaffolds in tissue engineering.After an introduction to various modeling techniques for nanostructures, simulation and analysis of graphene and CNT based scaffold have been conducted and studied. Conclusive models for single and multilayer graphene are provided which include nonlinear behaviour. An equivalent elastic modulus along with thickness is suggested for bending of single layer graphene based on its rolling into CNT. A contact model has been suggested for interlarlayer Van der Waals effect in graphene stacks which can be used in diverse analyses. The scaffold made from hybrid graphene-CNT structures is modeled using results from molecular structural mehcanics approach and continuum models are provided for scaffold and tissue interaction. A modal analysis showed that the scaffold structure has frequencies of order MHz which can be used as an excitation method during differentitation process. Results show that the stiffness and behavior of the scaffold can be adjusted by changing the CNT substrate properties, number of graphene leyaers and geometry of the structure, so that it can be used as an appropriate growth and differentiation factor
  9. Keywords:
  10. Scaffold ; Graphene ; Carbon Nanotubes ; Stem Cell ; Molecular Structural Mechanics ; Van Der Waals Model

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