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Microfluidic devices as invitro microenvironments for -stem cell culture
, Article Proceedings of the IASTED International Conference on Biomedical Engineering, BioMed 2014 ; 2014 , pp. 83-88 ; Abeddoust, M ; Mehboudi, N ; Sharif University of Technology
Abstract
Many potential therapies are currently being studied that may promote neural regeneration and guide regenerating axons to form correct connections following injury. It has been shown that adult neurons have some limited regenerative capabilities, and the lack of connection formation between neurons is not an intrinsic inability of these cells to form axons after being damaged, but rather the inhibitory microenvironment of the injured tissue prevents regeneration. In this study, the polarization and chemotaxis of neuronal stem cells (NSC) in response to quantified gradients of nerve growth factor (NGF) was examined. To accomplish this, a microfluidic device was designed and fabricated to...
A computational model for estimation of mechanical parameters in chemotactic endothelial cells
, Article Scientia Iranica ; Volume 23, Issue 1 , 2016 , Pages 260-267 ; 10263098 (ISSN) ; Shamloo, A ; Azimi, S ; Abeddoust, M ; Saidi, M.S ; Sharif University of Technology
Sharif University of Technology
Abstract
A cell migration numerical simulation is presented to mimic the motility of endothelial cells subjected to the concentration gradients of a Forebrain embryoniccortical neuron Conditioned Medium (CM). This factor was previously shflown to induce the directional chemotaxis of endothelial cells with an over-expressed G protein coupled receptor 124 (GPR 124). A cell simulator program incorporates basic elements of the cell cytoskeleton, including membrane, nucleus and cytoskeleton. The developed 2D cell model is capable of responding to concentration gradients of biochemical factors by changing the cytoskeleton arrangement. Random walk force, cell drag force and cell inertial effects are also...