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Synthesis of functionalized benzothiadiazine 1,1-dioxide derivatives via intramolecular C–H activation reactions of trichloroacetamidine and benzenesulfonyl chloride
, Article Tetrahedron Letters ; Volume 59, Issue 21 , 23 May , 2018 , Pages 2054-2056 ; 00404039 (ISSN) ; Rezaee, E ; Jahani, M ; Tabatabai, S. A ; Sharif University of Technology
Elsevier Ltd
2018
Abstract
The synthesis of functionalized benzothiadiazine 1,1-dioxide derivatives was achieved through a novel three-component intramolecular C–H activation reaction of trichloroacetonitrile, benzenesulfonyl chloride, and various primary amines. This reaction was performed in the presence of catalytic copper(I) and L-proline as the ligand in tetrahydrofuran at room temperature. © 2018 Elsevier Ltd