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Enzymatic formation of recombinant antibody-conjugated gold nanoparticles in the presence of citrate groups and bacteria
, Article Catalysts ; Volume 12, Issue 9 , 2022 ; 20734344 (ISSN) ; Ebrahimipour, G ; Bandehpour, M ; Akhavan, O ; Yarian, F ; Sharif University of Technology
MDPI
2022
Abstract
With the spread of deadly diseases worldwide, the design of rapid tests to identify causative microorganisms is necessary. Due to the unique properties of gold nanoparticles, these nanoparticles are used in designing rapid diagnostic tests, such as strip tests. The current study aimed to investigate the ability of gold nanoparticles to bind to single-chain variable fragment antibodies. In this study, the biological and chemical methods included Escherichia coli TOP-10 and the Turkevich method to synthesize the gold nanoparticles, respectively. Then, the effect of synthetic nanoparticles on their capability of binding to recombinant antibodies was assessed by agarose gel and UV-vis...
Magnetic nanocomposites for biomedical applications
, Article Advances in Colloid and Interface Science ; Volume 308 , 2022 ; 00018686 (ISSN) ; Ghovvati, M ; Rabiee, N ; Ahmadi, S ; Abbariki, N ; Sojdeh, S ; Ojaghi, A ; Bagherzadeh, M ; Akhavan, O ; Sharifi, E ; Rabiee, M ; Saeb, M. R ; Bolouri, K ; Webster, T. J ; Zare, E. N ; Zarrabi, A ; Sharif University of Technology
Elsevier B.V
2022
Abstract
Tissue engineering and regenerative medicine have solved numerous problems related to the repair and regeneration of damaged organs and tissues arising from aging, illnesses, and injuries. Nanotechnology has further aided tissue regeneration science and has provided outstanding opportunities to help disease diagnosis as well as treat damaged tissues. Based on the most recent findings, magnetic nanostructures (MNSs), in particular, have emerged as promising materials for detecting, directing, and supporting tissue regeneration. There have been many reports concerning the role of these nano-building blocks in the regeneration of both soft and hard tissues, but the subject has not been...
Customizing nano-chitosan for sustainable drug delivery
, Article Journal of Controlled Release ; Volume 350 , 2022 , Pages 175-192 ; 01683659 (ISSN) ; Vahidi, O ; Moghbeli, M ; Ahmadi, S ; Asadnia, M ; Akhavan, O ; Seidi, F ; Rabiee, M ; Saeb, M. R ; Webster, T. J ; Varma, R. S ; Sharifi, E ; Zarrabi, A ; Rabiee, N ; Sharif University of Technology
Elsevier B.V
2022
Abstract
Chitosan is a natural polymer with acceptable biocompatibility, biodegradability, and mechanical stability; hence, it has been widely appraised for drug and gene delivery applications. However, there has been no comprehensive assessment to tailor-make chitosan cross-linkers of various types and functionalities as well as complex chitosan-based semi- and full-interpenetrating networks for drug delivery systems (DDSs). Herein, various fabrication methods developed for chitosan hydrogels are deliberated, including chitosan crosslinking with and without diverse cross-linkers. Tripolyphosphate, genipin and multi-functional aldehydes, carboxylic acids, and epoxides are common cross-linkers used in...
A review on computer-aided chemogenomics and drug repositioning for rational COVID-19 drug discovery
, Article Chemical Biology and Drug Design ; Volume 100, Issue 5 , 2022 , Pages 699-721 ; 17470277 (ISSN) ; Taghavi Shahraki, B ; Rameh, F ; Nazarabi, M ; Fatahi, Y ; Akhavan, O ; Rabiee, M ; Mostafavi, E ; Lima, E. C ; Saeb, M. R ; Rabiee, N ; Sharif University of Technology
John Wiley and Sons Inc
2022
Abstract
Application of materials capable of energy harvesting to increase the efficiency and environmental adaptability is sometimes reflected in the ability of discovery of some traces in an environment―either experimentally or computationally―to enlarge practical application window. The emergence of computational methods, particularly computer-aided drug discovery (CADD), provides ample opportunities for the rapid discovery and development of unprecedented drugs. The expensive and time-consuming process of traditional drug discovery is no longer feasible, for nowadays the identification of potential drug candidates is much easier for therapeutic targets through elaborate in silico approaches,...
CaZnO-based nanoghosts for the detection of ssDNA, pCRISPR and recombinant SARS-CoV-2 spike antigen and targeted delivery of doxorubicin
, Article Chemosphere ; Volume 306 , 2022 ; 00456535 (ISSN) ; Akhavan, O ; Fatahi, Y ; Ghadiri, A. M ; Kiani, M ; Makvandi, P ; Rabiee, M ; Nicknam, M. H ; Saeb, M. R ; Varma, R. S ; Ashrafizadeh, M ; Nazarzadeh Zare, E ; Sharifi, E ; Lima, E. C ; Sharif University of Technology
Elsevier Ltd
2022
Abstract
Overexpression of proteins/antigens and other gene-related sequences in the bodies could lead to significant mutations and refractory diseases. Detection and identification of assorted trace concentrations of such proteins/antigens and/or gene-related sequences remain challenging, affecting different pathogens and making viruses stronger. Correspondingly, coronavirus (SARS-CoV-2) mutations/alterations and spread could lead to overexpression of ssDNA and the related antigens in the population and brisk activity in gene-editing technologies in the treatment/detection may lead to the presence of pCRISPR in the blood. Therefore, the detection and evaluation of their trace concentrations are of...
Reduced polydopamine coated graphene for delivery of Hset1 antisense as A photothermal and gene therapy of breast cancer
, Article Journal of Drug Delivery Science and Technology ; Volume 73 , 2022 ; 17732247 (ISSN) ; Tekie, F. S. M ; Ayazi, H ; Ranjbar, S ; Varshochian, R ; Rad-Malelkshahi, M ; Akhavan, O ; Dinarvand, R ; Sharif University of Technology
Editions de Sante
2022
Abstract
Breast cancer is the most prevalent type of cancer in women; hence, many researches have been focused on developing effective treatment protocols. In this study, a novel nanocarrier was fabricated for gene and photothermal combination cancer therapy by conjugating histone methyltransferase complex subunit SET1 (hSET1) on reduced polydopamine coated graphene oxide nanosheets (rGO-PDA). The rGO-PDA nanocarriers provide higher near-infrared absorption and further integrating with hSET1 antisense as an anticancer gene that down-regulates the amount of hSET1 overexpressed and suppresses the proliferation of cancer cells. The nanoplatform was prepared by polymerizing of dopamine, a mussel adhesive...
Immobilization of modular peptides on graphene cocktail for differentiation of human mesenchymal stem cells to hepatic-like cells
, Article Frontiers in Chemistry ; Volume 10 , 2022 ; 22962646 (ISSN) ; Hashemi, E ; Akhavan, O ; Khezri, J ; Rezaei, A ; Zamani Amir Zakria, J ; Siadat, S. D ; Sahebghadam Lotfi, A ; Farmany, A ; Sharif University of Technology
Frontiers Media S.A
2022
Abstract
In this study, two novel biomimetic modular peptide motifs based on the alpha-2 subunit of type IV collagen (CO4A2) were designed and immobilized on a graphene platform to imitate integrin and heparan sulfate- (HS-) binding proteins. The in silico study was used to design 9-mer K[KGDRGD]AG and 10-mer KK[SGDRGD]AG for testing designed Integrin-Binding Peptide (dIBP) and HS-Binding Peptide (dHBP). The virtual docking technique was used to optimize the peptide motifs and their relevant receptors. Molecular dynamic (MD) simulation was used to evaluate the stability of peptide-receptor complexes. The effect of the platform on the differentiation of human mesenchymal stem cells (hMSCs) to...
Silver and gold nanoparticles for antimicrobial purposes against multi-drug resistance bacteria
, Article Materials ; Volume 15, Issue 5 , 2022 ; 19961944 (ISSN) ; Ahmadi, S ; Akhavan, O ; Luque, R ; Sharif University of Technology
MDPI
2022
Abstract
Several pieces of research have been done on transition metal nanoparticles and their nanocomplexes as research on their physical and chemical properties and their relationship to biological features are of great importance. Among all their biological properties, the antibacterial and antimicrobial are especially important due to their high use for human needs. In this article, we will discuss the different synthesis and modification methods of silver (Ag) and gold (Au) nanoparticles and their physicochemical properties. We will also review some state-of-art studies and find the best relationship between the nanoparticles’ physicochemical properties and potential antimicrobial activity. The...
Strain effects on optical properties of linearly polarized resonant modes in the presence of monolayer graphene
, Article Materials Science and Engineering B: Solid-State Materials for Advanced Technology ; Volume 277 , 2022 ; 09215107 (ISSN) ; Jahani, D ; Akhavan, O ; Sharif University of Technology
Elsevier Ltd
2022
Abstract
Recently, huge attention has been drawn to improve optical sensing devices based on photonic resonators in the presence of graphene. In this paper, based on the transfer matrix approach and TE polarization of the incident electromagnetic waves, we numerically evaluate the transmission and reflection spectra for one-dimensional photonic resonators and surface plasmon resonances with strained graphene, respectively. We proved that a relatively small strain field in graphene can modulate linearly polarized resonant modes within the photonic bandgap of the defective crystal. Moreover, we study the strain effects on the surface plasmon resonances created by the evanescent wave technique at the...
Green metal-organic frameworks (MOFs) for biomedical applications
, Article Microporous and Mesoporous Materials ; Volume 335 , 2022 ; 13871811 (ISSN) ; Atarod, M ; Tavakolizadeh, M ; Asgari, S ; Rezaei, M ; Akhavan, O ; Pourjavadi, A ; Jouyandeh, M ; Lima, E. C ; Hamed Mashhadzadeh, A ; Ehsani, A ; Ahmadi, S ; Saeb, M. R ; Sharif University of Technology
Elsevier B.V
2022
Abstract
Metal-organic frameworks (MOFs), known as highly ordered crystalline hybrid structures, are the products of coordination polymerization of transition metals and organic ligands. MOFs are best known for their extensive specific surface area, hierarchically porous and tailorable 1D, 2D, or 3D micro-and nanostructure, and acceptable biocompatibility. Because of the multiplicity of metallic and organic units used in MOFs synthesis, tailor-made MOFs can be synthesized to be served as building blocks of advanced biological materials and systems. Recently, synthesis of green MOFs has received much more attention for nanobiomedicine usage. We review herein synthesis and biomedical application of...
Nanomaterials for photocatalytic degradations of analgesic, mucolytic and anti-biotic/viral/inflammatory drugs widely used in controlling sars-CoV-2
, Article Catalysts ; Volume 12, Issue 6 , 2022 ; 20734344 (ISSN) ; Akhavan, O ; Sharif University of Technology
MDPI
2022
Abstract
The COVID-19 pandemic has been transformed into one of the main worldwide chal-lenges, in recent years. For controlling symptoms that are caused by this disease (e.g., chills or fever, shortness of breath and/or difficulty in breathing, cough, sore throat, fatigue, headache, muscle aches, the new loss of tastes and/or smells, congestion or runny nose, nausea, vomiting and/or diar-rhea), lots of medicines including analgesics, mucolytics, and anti-biotic/viral/inflammatory drugs have been frequently prescribed. As these medicines finally contaminate terrestrial and aquatic hab-itats by entering surface waterways through pharmaceutical production and excreting trace amounts of waste after...
Graphene nanopores in broadband wide-angle optical cavity resonance absorbers
, Article Surfaces and Interfaces ; Volume 30 , 2022 ; 24680230 (ISSN) ; Akhavan, O ; Sharif University of Technology
Elsevier B.V
2022
Abstract
A cavity resonator containing graphene nanopores (GNPs), along with a metallic layer (Ag, as a reflector) and a dielectric layer (SiO2, as a spacer), has been proposed for broadband wide-angle absorption of light. The GNP/SiO2/Ag multilayers showed high significant increase in the absorption efficiency (with respect to the G/SiO2/Ag multilayer) in a broad spectral range (from ultra-violet (UV) and visible range to near-infrared (NIR)), due to the cavity resonance and absorptions induced by the oxygen-containing functional groups formed around the nanopores of graphene. The dependences of the cavity resonance absorption on the quality of the GNP layer, dimension of the cavity and the incident...
Engineered Biomimetic Membranes for Organ-on-a-Chip
, Article ACS Biomaterials Science and Engineering ; Volume 8, Issue 12 , 2022 , Pages 5038-5059 ; 23739878 (ISSN) ; Rasouli, F ; Jahangiri, S ; Ahmadi, S ; Rabiee, N ; Ramezani Farani, M ; Akhavan, O ; Asadnia, M ; Fatahi, Y ; Hong, S ; Lee, J ; Lee, J ; Hahn, S. K ; Sharif University of Technology
American Chemical Society
2022
Abstract
Organ-on-a-chip (OOC) systems are engineered nanobiosystems to mimic the physiochemical environment of a specific organ in the body. Among various components of OOC systems, biomimetic membranes have been regarded as one of the most important key components to develop controllable biomimetic bioanalysis systems. Here, we review the preparation and characterization of biomimetic membranes in comparison with the features of the extracellular matrix. After that, we review and discuss the latest applications of engineered biomimetic membranes to fabricate various organs on a chip, such as liver, kidney, intestine, lung, skin, heart, vasculature and blood vessels, brain, and multiorgans with...
Electrically conductive carbon-based (bio)-nanomaterials for cardiac tissue engineering
, Article Bioengineering and Translational Medicine ; 2022 ; 23806761 (ISSN) ; Rabiee, M ; Baheiraei, N ; Ghahremanzadeh, R ; Salarian, R ; Rabiee, N ; Akhavan, O ; Zarrintaj, P ; Hejna, A ; Saeb, M. R ; Zarrabi, A ; Sharifi, E ; Yousefiasl, S ; Zare, E. N ; Sharif University of Technology
John Wiley and Sons Inc
2022
Abstract
A proper self-regenerating capability is lacking in human cardiac tissue which along with the alarming rate of deaths associated with cardiovascular disorders makes tissue engineering critical. Novel approaches are now being investigated in order to speedily overcome the challenges in this path. Tissue engineering has been revolutionized by the advent of nanomaterials, and later by the application of carbon-based nanomaterials because of their exceptional variable functionality, conductivity, and mechanical properties. Electrically conductive biomaterials used as cell bearers provide the tissue with an appropriate microenvironment for the specific seeded cells as substrates for the sake of...
Graphene-based nanomaterials in fighting the most challenging viruses and immunogenic disorders
, Article ACS Biomaterials Science and Engineering ; Volume 8, Issue 1 , 2022 , Pages 54-81 ; 23739878 (ISSN) ; Asadi, M ; Akhavan, O ; Sharif University of Technology
American Chemical Society
2022
Abstract
Viral diseases have long been among the biggest challenges for healthcare systems around the world. The recent Coronavirus Disease 2019 (COVID-19) pandemic is an example of how complicated the situation can get if we are not prepared to combat a viral outbreak in time, which brings up the need for quick and affordable biosensing platforms and vast knowledge of potential antiviral effects and drug/gene delivery opportunities. The same challenges have also existed for nonviral immunogenic disorders. Nanomedicine is considered a novel candidate for effectively overcoming these worldwide challenges. Among the versatile nanomaterials commonly used in biomedical applications, graphene has recently...
Aperiodic perforated graphene in optical nanocavity absorbers
, Article Materials Science and Engineering B: Solid-State Materials for Advanced Technology ; Volume 276 , 2022 ; 09215107 (ISSN) ; Akhavan, O ; Salami, P ; Yousefi, L ; Sharif University of Technology
Elsevier Ltd
2022
Abstract
Aperiodic perforated graphene layers were synthesized and used in fabrication of optical nanocavity absorbers. Chemical vapor deposition-grown graphene (Gr) layers were exposed to oxygen plasma etching to obtain the perforated graphene (pGr). The fabricated pGr/SiO2 (68 nm)/Ag (150 nm) nanocavity could present significant higher optical absorption, especially at around 530 nm wavelength region, as compared to a benchmark Gr/SiO2 (68 nm)/Ag (150 nm) sample. The effect of pore size of the pGr layer on the absorption property of the nanocavity has been studied by both experimental and numerical methods. The dependence of the absorption property of the nanocavity on the incident angles of...
Green porous benzamide-like nanomembranes for hazardous cations detection, separation, and concentration adjustment
, Article Journal of Hazardous Materials ; Volume 423 , 2022 ; 03043894 (ISSN) ; Fatahi, Y ; Asadnia, M ; Daneshgar, H ; Kiani, M ; Ghadiri, A. M ; Atarod, M ; Mashhadzadeh, A. H ; Akhavan, O ; Bagherzadeh, M ; Lima, E. C ; Saeb, M. R ; Sharif University of Technology
Elsevier B.V
2022
Abstract
Green biomaterials play a crucial role in the diagnosis and treatment of diseases as well as health-related problem-solving. Typically, biocompatibility, biodegradability, and mechanical strength are requirements centered on biomaterial engineering. However, in-hospital therapeutics require an elaborated synthesis of hybrid and complex nanomaterials capable of mimicking cellular behavior. Accumulation of hazardous cations like K+ in the inner and middle ear may permanently damage the ear system. We synthesized nanoplatforms based on Allium noeanum to take the first steps in developing biological porous nanomembranes for hazardous cation detection in biological media. The...
Green products from herbal medicine wastes by subcritical water treatment
, Article Journal of Hazardous Materials ; Volume 424 , 2022 ; 03043894 (ISSN) ; Tavakoli, O ; Sarkhanpour, R ; Sajadi, S. M ; Zarrintaj, P ; Rabiee, N ; Akhavan, O ; Lima, E. C ; Saeb, M. R ; Sharif University of Technology
Elsevier B.V
2022
Abstract
Herbal medicine wastes (HMWs) are byproducts of medicine factories, which are mainly landfilled for their environmental problems. Only bearing in mind the contamination and concerns caused by the COVID-19 pandemic and environmental emissions, the worth of herbal medicine wastes management and conversion to green products can be understood. In this work, subcritical water treatment was carried out batch-wise in a stainless tube reactor in the pressure range of 0.792–30.0 MPa, varying the temperature (127–327 °C) and time (1–60 min) of extraction. This resulted in new and green material sources, including organic acids, amino acids, and sugars. Amazingly, at very low extraction times (below 5...
Metal-organic frameworks (MOF) based heat transfer: A comprehensive review
, Article Chemical Engineering Journal ; Volume 449 , 2022 ; 13858947 (ISSN) ; Jouyandeh, M ; Mohammad Sajadi, S ; Hejna, A ; Habibzadeh, S ; Mohaddespour, A ; Rabiee, N ; Daneshgar, H ; Akhavan, O ; Asadnia, M ; Rabiee, M ; Ramakrishna, S ; Luque, R ; Reza Saeb, M ; Sharif University of Technology
Elsevier B.V
2022
Abstract
Higher than a standard level, the humidity provides a suitable environment for the pathogenic microorganisms to grow and increases energy consumption for cooling, increasing greenhouse gas emissions. Desiccant air-conditioning (DAC) is an effective method to reduce humidity and energy simultaneously. Conventional desiccants are not suitable for use as a desiccant in building air conditioners, mainly because of high regeneration temperature and other issues such as limited equilibrium capacity and hydrothermal and cyclic instability. Metal-organic frameworks (MOFs) are a novel class of porous crystalline materials without the disadvantages of traditional desiccants. They benefit from a huge...
Synthesis, morpho-structural properties, and catalytic performances of Pt-APA@Fe3O4/GO nanocomposite based on magnetical graphene in C–C coupling reactions and photoinactivation of E. coli
, Article Journal of Nanoparticle Research ; Volume 23, Issue 8 , 2021 ; 13880764 (ISSN) ; Sabounchei, S. J ; Yousefi, A ; Akhavan, O ; Sharif University of Technology
Springer Science and Business Media B.V
2021
Abstract
Herein, a novel Pt-APA composite (APA = pyridinium bromide salt) based on magnetic graphene oxide was synthesized and used as an effective catalyst. In this way, Fe3O4 nanoparticles are grown on graphene oxide (GO) nanosheets by a simple and practical method which creates a unique nanostructure (Fe3O4/GO) through dispersing uniformly among graphene nanosheets. The resulted Pt-APA composite was obtained via adding PtCl2 to an ethanol solution of Fe3O4/GO and α-keto stabilized pyridinium ylide in related conditions. The synthesized nanocomposite structure was identified using field emission scanning electron microscopy (FE-SEM), transmission electron microscopy (TEM), energy dispersive...