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Biomimetic apatite layer formation on a novel citrate starch scaffold suitable for bone tissue engineering applications
, Article Starch/Staerke ; Volume 68, Issue 11-12 , 2016 , Pages 1275-1281 ; 00389056 (ISSN) ; Shahriarpanah, S ; Asadzadehzanjani, N ; Khaleghpanah, S ; Heidari, S ; Sharif University of Technology
Wiley-VCH Verlag
2016
Abstract
The formation of biomimetic bone-like apatite layers throughout the biopolymer-based hydrogel scaffold is an attractive approach in bone tissue engineering. Here, the starch scaffold was prepared using a combination of particulate leaching and freeze-drying techniques. The fabricated structures were then modified by citric acid to investigate the formation of bone-like apatite layer on the porous citrate-based scaffold after soaking in simulated body fluid (SBF). The Fourier Transform Infrared (FTIR) spectra and X-ray diffraction (XRD) patterns revealed that the B-type carbonated apatite has successfully deposited on the scaffold after immersing in SBF for 28 days. Indeed, high chemical...