Sharif Digital Repository

Phospholipid membranes and vesicles play important roles in the cellular functioning, otein signaling and material transport inside cells. Protein-embedded vesiclesare also used for targeted drug delivery. In this thesis, we use molecular dynamicsmethods and study (i) the formation of vesicles from flat lipid bilayers (ii) the mechanicalproperties of vesicles under compressive forces (iii) the shape variations ofvesicles with and without transmembrane proteins (iv) protein clustering.We grow our vesicles from lipid bilayers, which may contain proteins with differentconcentrations. We start with a random initial distribution of proteins that allowsus to monitor the clustering and... 

In this thesis an SPH method is used for simulating multiphase two- and three-dimensional Newtonian fluid flows. The weakly compressible algorithm consists of two steps of prediction and correction. In the prediction step, the velocity field is integrated forward in time without enforcing incompressibility. The correction step consists of enforcing incompressibility by solving the pressure Poisson equation which creates a trade-off between the pressure and density variations. The surface tension force is applied in the linear momentum conservation equation by the divergence of the surface stress tensor. Advanced techniques are applied to achieve better convergence and reduce pressure-related... 

Cancer has been known as one of the main reasons for disease-related deaths in the last decades. Early diagnosis could significantly reduce the level of fatality chances. Among the known cancer types, lung cancer is one of the most malignant ones. The common diagnosticmethods are expensive and using high-technology methods; therefore, the introduction of simple and cheap methods is very urgent to detect it. In this project, surface and interfacial tension measurement of cancerous and normal lung cells have been investigated as an easy detection technique. Among the common measurement methods, Pendant Drop and Capillary height techniques have been utilized in this research work. The obtained... 

Due to the fact that, over 60% of oil reserves are located in fractured reservoirs, this type of reservoirs requires a great deal of attention. The presence of the fractures in porous media results in many complexities in the liquid path and production, consequently, simulation and modeling of flow equations is highly important. In order to achieve a more profound understanding of liquid flow in gravity drainage mechanism, the concept of capillary tubes is initially used. By using the capillary tube concept, at first, the gravity drainage mechanism is investigated in the first block in a stack of blocks and an analytical solution is presented for this case. Then, the stack of blocks is... 

Drop penetration into the capillary tube, as a classical problem, has been studied over 100 years. But there are a few studies that investigate forced impregnation of capillary tubes, which has major application in coating, inkjet printing and rain drop penetration into the soil, have been made. A comprehensive numerical investigation on millimeter droplet impact dynamics on a thick capillary tube with micrometer sized pore is conducted and validated against experimental data. This work is extended to oblique impact of drops into pores and normal impact on nanoscaled pores. We apply the finite volume numerical method to solve the time-dependent governing equations of continuity, momentum in...