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cardiotoxicity
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Investigating the Effect of Lymph Vessel Applying in Organ-On-A-Chip System to Improve the Biomimicry-Inspired Design Strategy
, M.Sc. Thesis Sharif University of Technology ; Yaghmaei, Soheila (Supervisor) ; Mashayekhan, Shohreh (Co-Supervisor)
Abstract
In the last decade, the application of organ-on-chip systems to investigate the effectiveness and side effects of various drugs, modele diseases for different tissues has become noticed a lot because these systems are a promising approach to eliminate animal tests and clinical studies on different people. Current conventional methods for drug testing are expensive, time-consuming, and sometimes unreliable. Various organ-on-a-chip systems have been fabricated in order to mimic the conditions of different native tissues in the human body, but only the blood vessel has been considered in most of them while besides blood vessels, as a source to nourish cells, there are lymph vessels as a sink in...
Combined effects of electric stimulation and microgrooves in cardiac tissue-on-a-chip for drug screening
, Article Small Methods ; Volume 4, Issue 10 , 2020 ; Zhou, X ; Nasiri, R ; Fang, J ; Jiang, X ; Wang, C ; Qu, M ; Ling, H ; Chen, Y ; Xue, Y ; Hartel, M.C ; Tebon, P ; Zhang, S ; Kim, H.-J ; Yuan, X ; Shamloo, A ; Dokmeci, M. R ; Li, S ; Khademhosseini, A ; Ahadian, S ; Sun, W ; Sharif University of Technology
John Wiley and Sons Inc
2020
Abstract
Animal models and traditional cell cultures are essential tools for drug development. However, these platforms can show striking discrepancies in efficacy and side effects when compared to human trials. These differences can lengthen the drug development process and even lead to drug withdrawal from the market. The establishment of preclinical drug screening platforms that have higher relevancy to physiological conditions is desirable to facilitate drug development. Here, a heart-on-a-chip platform, incorporating microgrooves and electrical pulse stimulations to recapitulate the well-aligned structure and synchronous beating of cardiomyocytes (CMs) for drug screening, is reported. Each chip...