Sharif Digital Repository

Governments in developing countries have invested in institutions of higher learning in order to develop homegrown, high technology products. Among these, the National University of Malaysia (Universiti Kebangsaan Malaysia), recognized as a Research University, is actively involved in projects related to medical technology through its various faculties. The net result of these activities is impressing from the point of view of patents and publications, but unfortunately not yet in terms of commercialization. This paper starts by presenting the main obstacles towards the objective of bringing a laboratory prototype to the market in the context of Malaysia. Then, a framework is presented... 

Cardiovascular diseases contribute to one third of the world's mortality and morbidity, therefore early cardiovascular disease diagnosis, treatment and monitoring has become an important market. Ideally, an early diagnosis device will need to be accurate, non-invasive, low cost and operator independent. Interestingly enough, there is a wide range of non-invasive devices available, but each with a different degree of accuracy and ease of use. In this paper, an attempt has been made to review commercially available technologies for non-invasive vascular screening. As stiffness index, reflection index, augmentation index, central aortic pressure are most commonly used to screen for vascular... 

The feasibility of a novel system to reliably estimate the normalized central blood pressure (CBPN) from the radial photoplethysmogram (PPG) is investigated. Right-wrist radial blood pressure and left-wrist PPG were simultaneously recorded in five different days. An industry-standard applanation tonometer was employed for recording radial blood pressure. The CBP waveform was amplitude-normalized to determine CBPN. A total of fifteen second-order autoregressive models with exogenous input were investigated using system identification techniques. Among these 15 models, the model producing the lowest coefficient of variation (CV) of the fitness during the five days was... 

Ageing is one of the main contributing factors towards increasing arterial stiffness, leading to changes in peripheral pulses propagation. Therefore the characteristics of the photoplethysmogram (PPG) pulse, especially the rising edge and peak position, are greatly affected. In this study, the PPG pulse rising edge and corresponding peak position have been investigated non-invasively in human subjects as a function of age. Fifteen healthy subjects were selected and grouped in five age intervals, from 20 to 59 years, based on their comparable systolic-diastolic blood pressure and PPG amplitude. As expected, the peripheral pulse shows a steep rise and early peak in younger subjects. With age,...