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Cell-cell interactions mediate cytoskeleton organization and collective endothelial cell chemotaxis
, Article Cytoskeleton ; Vol. 71, issue. 9 , 2014 , p. 501-512 ; Sharif University of Technology
Abstract
This study investigates the role of cell-cell and cell-ligand interactions in cytoskeleton organization of endothelial cells (ECs) and their directional migration within a microfluidic device. The migration of ECs in response to a biochemical factor was studied. Mathematical analysis of the cell migration pathways and cellular cytoskeleton revealed that directional migration, migration persistence length, migration speed, and cytoskeletal stress fiber alignment can be mediated by the level of cell contacts as well as the presence or absence of a biochemical polarizing factor. It was shown that in the presence of a biochemical polarizing factor, higher cell density and more frequent cell...