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    , Ph.D. Dissertation Sharif University of Technology Koushki, Behzad (Author) ; Matloubi Moghaddam, Firouz (Supervisor)
    Abstract
    We have reported a new and efficient synthesis of a broad spectrum of heterotetracyclic benzoxazocines via unique tandem 1,3-dinucleophilic addition of different bifunctional nucleophiles to quinolinium and isoquinolinium salts. The reaction generally involves the initial addition of nucleophiles to quinolinium salts to form enamine intermediate which can be trapped by intramolecular O/S-alkylation of nucleophiles. In the third part, as continues, we have reported another method which consists of Anthocyanidins and Thioindoles by using water and acetic acid as the solvent. This protocol is a very mild and simple method for construction of eight-membered ring in fused heterocycles in a... 

    Investigation of Thermodynamic Relations in Microscopic Systems by Quantum Information Theory

    , M.Sc. Thesis Sharif University of Technology Badiei, Alireza (Author) ; Shafiee, Afshin (Supervisor) ; Shamkhali, Amir Naser (Supervisor)
    Abstract
    Entropy is one of the important quantities in thermodynamics. In this project has tried to make this quantity as a bridge between quantum and thermodynamics. Entropy has many definitions that the Shannon entropy is chosen in this work. By this definition of entropy, we are able to define the entropy for a electronic system in molecules. By this definition, we are seeking an answer for this question,”whether entropy has a similar application in quantum like thermodynamics or not?”. To elucidate this hypothesis, simple diatomic molecules are computed. In fact, displacement of the Shannon entropy has investigated in bond making process. The question is that whether we can use this quantity to... 

    Experimental Study on Extracting Clean Energy from Vortex Induced Vibration

    , M.Sc. Thesis Sharif University of Technology Mohtat, Pouya (Author) ; Abbaspour, Majid (Supervisor)
    Abstract
    Two experimental models were designed and tested to extract energy from vortex induced vibrations of a elastically mounted one degree of freedom rigid cylinder in the Reynolds range of 120000 < Re <220000. In the first model the amplitude and frequency of the movement was measured then a second model was designed to be tested in the Emam Hossein marine laboratory. The model was designed in a way that many of its properties like mass ratio, spring constant and damping coefficient were able to be altered. In this study the vortex induced vibration of an elastically mounted cylinder was scrutinized in high Reynolds and very low mass ratios for the first time and an amplitude ratio of 2.49 were... 

    A Model for Analysis of Computational Learning

    , M.Sc. Thesis Sharif University of Technology Sattari Javid, Ali (Author) ; Daneshgar, Amir (Supervisor)
    Abstract
    The subject of this thesis is about a certain set of algorithms that try to indirectly solve problems. Instead of a programmer crafting an algorithm to solve a problem, these algorithms learn a solution themselves. These methods are usually studied in the Probably Accurately Correct (PAC) learning model. Although, PAC Learning is a generally accepted model, it falls short to describe certain aspects of learning algorithms. Many learning methods rely on convergence to minimize error, or maximize their fitness, yet the PAC model doesn’t explicitly provide any means to measure these behaviours. In this thesis, we first go through different models related to computational requirements of... 

    Modeling of Visual Attention Mechanism by Brain Signals

    , M.Sc. Thesis Sharif University of Technology Pahlevan Aghababa, Fatemeh (Author) ; Beigy, Hamid (Supervisor)
    Abstract
    Attention is a cognitive process in which the mind reacts to certain stimuli or stimuli of the environment while other environmental stimuli are ignored. Attention might be an overt or covert process. Overt attention is a process in which based on the purpose, we selectively choose an object or place among other objects and places to focus on and we are aware of it. However, the covert attention originates from hidden source, and we are not aware of it. In fact, the covert attention causes a clear and rapid movement of the eye toward the stimulus or space to be taken into consideration and the time when the movement of the eye it means overt attention has occurred. Visual attention is given... 

    Protein Function Prediction Using Protein Structure and Computational Methods

    , M.Sc. Thesis Sharif University of Technology Abbasi Dezfouli, Mohammad Ebrahim (Author) ; Fatemizadeh, Emad (Supervisor) ; Arab, Shahriar ($item.subfieldsMap.e)
    Abstract
    Predicting the Amino Acids that have a catalytic effect in the enzymes, is a big step in appointing the activity of the enzymes and classifying them. This is a very challenging job, because an Amino Acid can appear in a variety of active sites.The biological activity of a protein usually depends on the existence of a small number of Amino Acids. Detecting these Amino Acids from the sequence of Amino Acids has many applications. Usually, the Amino Acids that are preserved are known as the Amino Acids that build up the active site, but the algorithms for finding the preserved Amino Acids are much more complex. There are a lot of algorithms for predicting the active sites of Amino Acids, but... 

    Investigating the Effect of the Proposed CSF-1R Protein Inhibitor,with a Structure Containing Natural Biomolecules and based on the Approved Drug Vimseltinib

    , M.Sc. Thesis Sharif University of Technology Ebtehaj, Pouria (Author) ; Fattahi, Alireza (Supervisor)
    Abstract
    Vimseltinib, a small molecule inhibitor, represents a promising avenue for combating cancers linked to macrophage-associated processes through its targeted action on the CSF1R tyrosine kinase receptor. CSF1R, a pivotal member of the tyrosine kinase receptor family, plays a crucial role in macrophage differentiation and function. This protein's significance is underscored in conditions such as tenosynovial giant cell tumors (TGCTs) and the presence of tumor-associated macrophages, wherein overproduction of CSF1 by neoplastic cells recruits CSF1R-dependent immune cells, fostering tumor expansion. The intricate interplay extends to tumor-associated macrophages, particularly the M2 subtype,... 

    An investigation on the dynamic response of the shaking table steel deck using finite element

    , Article 11th World Congress on Computational Mechanics, WCCM 2014, 5th European Conference on Computational Mechanics, ECCM 2014 and 6th European Conference on Computational Fluid Dynamics, ECFD 2014 ; 2014 , pp. 1330-1340 ; ISBN: 9788494284472 Moghaddam, H ; Farzanian, K ; Taheri, E ; Sharif University of Technology
    Abstract
    This paper presents the results of an analytical study on the dynamic characteristics of the Shaking Table facilities at Sharif University. This 3 degree of freedom shaking table is driven by 3 servo-control hydraulic actuators, and consists of a 12 ton, 4m×4m×0.6m steel deck. The main objective of this investigation is to identify the degree of flexibility of the deck, and its adverse effects in causing errors in the simulation of seismic effects on different structural specimens. Many frame specimens of different weights and configurations are subjected to seismic motions, and their responses are calculated using FE models. Some of these models were designed to account for eccentric... 

    Soft computing method for prediction of co2 corrosion in flow lines based on neural network approach

    , Article Chemical Engineering Communications ; Volume 200, Issue 6 , 2013 , Pages 731-747 ; 00986445 (ISSN) Chamkalani, A ; Nareh'ei, M. A ; Chamkalani, R ; Zargari, M. H ; Dehestani Ardakani, M. R ; Farzam, M ; Sharif University of Technology
    2013
    Abstract
    An important aspect of corrosion prediction for oil/gas wells and pipelines is to obtain a realistic estimate of the corrosion rate. Corrosion rate prediction involves developing a predictive model that utilizes commonly available operational parameters, existing lab/field data, and theoretical models to obtain realistic assessments of corrosion rates. This study presents a new model to predict corrosion rates by using artificial neural network (ANN) systems. The values of pH, velocity, temperature, and partial pressure of the CO2 are input variables of the network and the rate of corrosion has been set as the network output. Among the 718 data sets, 503 of the data were implemented to find... 

    Investigation on effects of the sleeper defects on rail vehicle vibration

    , Article ASME 2012 International Design Engineering Technical Conferences and Computers and Information in Engineering Conference, IDETC/CIE 2012, Chicago, IL, 12 August 2012 through 12 August 2012 ; Volume 1, Issue parts A and B , 2012 , Pages 865-871 ; 9780791845004 (ISBN) Mortezaee, H ; Jalili, M. M ; Ahmadian, M. T ; Sharif University of Technology
    2012
    Abstract
    In this article effects of sleepers defect on rail vehicle vibration have been investigated. Two parallel rails of the track have been modeled as Euler-Bernoulli beams on elastic points as rail pads. Also sleepers have been modeled as visco-elastic Euler-Bernoulli beams. It is assumed that, some sleepers under the rail track have been fractured and modeled by two beams. The wheelset has 5 DOF which are longitudinal, vertical and lateral movements plus roll and axial rotations. To determine normal contact force between wheel and rail, relative position of wheel and rail has been determined at each instant. Using the coordinate of each wheel points in rail coordinate system, the penetration of... 

    Time and space extended-particle in cell model for electromagnetic particle algorithms

    , Article Physics of Plasmas ; Volume 19, Issue 3 , 2012 ; 1070664X (ISSN) Yazdanpanah, J ; Anvari, A ; Sharif University of Technology
    Abstract
    A general method for deriving electromagnetic particle in cell (EMPIC) algorithms has been given by Eastwood [Comput. Phys. Commun. 64, 252 (1991)]. This method devises variation of the action-integral to find discrete governing equations. The most important advantage of this method is automatic inclusion of the time coordinate via the action integral into the computational domain. This inclusion is inevitable because electromagnetic algorithms are based on time evolution of the system from its initial state. The drawback of this method is that it is rather abstract. This causes obscurity of particle-mesh interactions and makes it hard to analyze physical treatments of the computational... 

    A combinational logic optimization for majority gate-based nanoelectronic circuits based on GA

    , Article 2011 International Semiconductor Device Research Symposium, ISDRS 2011, College Park, MD, 7 December 2011 through 9 December 2011 ; 2011 ; 9781457717550 (ISBN) Roohi, A ; Kamrani, M ; Sayedsalehi, S ; Navi, K ; Sharif University of Technology
    Abstract
    Quantum dots cellular automata is a new computing method in the nanotechnology that has considerable features such as low power, small dimension and high speed switch. A QCA device stores logic based on the position of individual electrons. The fundamental logic elements in QCA are the majority (Fig.1 (a)) and inverter gates (Fig.1 (b)) that operate based on the Coulomb repulsion between electrons [1]  

    A computational model for health monitoring of storage tanks using fiber Bragg grating optical fiber

    , Article Journal of Civil Structural Health Monitoring ; Volume 1, Issue 3-4 , 2011 , Pages 97-102 ; 21905452 (ISSN) Sarkandi, G. I ; Zabihollah, A ; Sharif University of Technology
    Abstract
    Storage tanks are always under different hazards such as corrosion and leaking. In this work we have introduced a computational analysis on storage tanks in which a real-time yet efficient monitoring technique using Fiber Bragg Grating (FBG) sensors for corrosion detection on the bottom plate and vibration monitoring on outer surfaces of storage tanks is proposed. A finite element model for the tank is developed, in which the outer tanks surfaces are considered as plate elements and FBG sensors as beam elements. An array of FBG sensors is utilized to compute the generated strain in the FBGs due to losing thickness in the tank's bottom plate and due to vibration on the outer surfaces in... 

    Location finding in wireless sensor network based on soft computing methods

    , Article 2011 International Conference on Control, Automation and Systems Engineering, CASE 2011, 30 July 2011 through 31 July 2011 ; July , 2011 , Page(s): 1 - 5 ; 9781457708602 (ISBN) Nekooei, S. M ; Manzuri Shalmani, M. T ; Singapore Management University ; Sharif University of Technology
    2011
    Abstract
    Sensor Localization is a crucial part of many location-dependent applications that is utilized in wireless sensor networks (WSNs). Several approaches, including range-based and range-free, have been proposed to calculate the position of randomly deployed sensor nodes. With specific hardware, the range-based schemes typically achieve high accuracy based on either node-to-node distances or angles. On the other hand, the range-free mechanisms support less positioning accuracy with less expense. The proposed scheme is based on range-free localization, which utilizes the received signal strength (RSS) from the anchor nodes. In this work, genetic fuzzy and neuro-fuzzy methods are used to become... 

    A hybrid computer simulation-genetic algorithm for scheduling optimisation of cargo trains with time and queue limitations

    , Article International Journal of Industrial and Systems Engineering ; Volume 8, Issue 2 , 2011 , Pages 157-174 ; 17485037 (ISSN) Azadeh, A ; Izadbakhsh, H. R ; Mohammadhosseinzad, M ; Raissifard, M. R ; Sharif University of Technology
    2011
    Abstract
    This paper presents the scheduling optimisation of cargo trains by hybrid computer simulation (CS) and genetic algorithm. Scheduling cargo trains is based on the timetable of passenger trains that have priority in relation to cargo trains. System modelling is accomplished by Visual SLAM by considering time limitations, queue priority and limited station lines. Time limitations define that a cargo train is permitted to travel from station i to j if scheduled passenger trains have completed the travel from station i to j. Queue priority means that passenger trains have priority over cargo trains. In addition, each station has a limited storage track. In addition, all repair, maintenance,... 

    Integrative Utilization of Microenvironments, Biomaterials and Computational Techniques for Advanced Tissue Engineering

    , Article Journal of Biotechnology ; Volume 212 , 2015 , Pages 71-89 ; 01681656 (ISSN) Shamloo, A ; Mohammadaliha, N ; Mohseni, M ; Sharif University of Technology
    Elsevier  2015
    Abstract
    This review aims to propose the integrative implementation of microfluidic devices, biomaterials, and computational methods that can lead to a significant progress in tissue engineering and regenerative medicine researches. Simultaneous implementation of multiple techniques can be very helpful in addressing biological processes. Providing controllable biochemical and biomechanical cues within artificial extracellular matrix similar to in vivo conditions is crucial in tissue engineering and regenerative medicine researches. Microfluidic devices provide precise spatial and temporal control over cell microenvironment. Moreover, generation of accurate and controllable spatial and temporal... 

    A non-iterative linear inverse solution for the block approach in EIT

    , Article Journal of Computational Science ; Volume 1, Issue 4 , 2010 , Pages 190-196 ; 18777503 (ISSN) Abbasi, A ; Vahdat, B. V ; Sharif University of Technology
    2010
    Abstract
    Electrical impedance tomography (EIT) is a simple, economic and healthy technique to capture images from the internal area of the body. Although EIT is cheaper and smaller than other imaging systems and requires no ionizing radiation, the resolution associated with this technique is intrinsically limited and the image reconstruction algorithms proposed up to now are not efficient enough. In addition to low resolution EIT is an ill-posed inverse problem. Block method in EIT is based on electrical properties of materials and used to enhance image resolution and also to improve the reconstruction algorithm. Recently an inverse solution for EIT based on block method has been developed, however,... 

    Simulation of Red Blood Cell mechanical behavior in optical tweezers experiment based on a particle method

    , Article ASME International Mechanical Engineering Congress and Exposition, Proceedings (IMECE), 12 November 2010 through 18 November 2010 ; Volume 2 , 2010 , Pages 325-329 ; 9780791844267 (ISBN) Ahmadian, M. T ; Firoozbakhsh, K ; Hasanian, M
    Abstract
    Optical tweezers provide an accurate measurement technique for evaluating mechanical properties of the living cells and many experimental studies have been done to understand the behavior of cells due to external forces. Numerical studies such as finite element methods have been used in order to simulate mechanical behavior of the Red Blood Cells (RBCs). Recent studies have shown that the particle methods are useful tools to simulate the mechanical behavior of living cells. Since in microscopic scales, using discrete models are preferred than continuum methods, a particle-based method is used to simulate the deformation of RBC which is stretched by optical tweezers. The cytoplasm of RBC is... 

    Towards a bounded-rationality model of multi-agent social learning in games

    , Article 2010 10th International Conference on Intelligent Systems Design and Applications, ISDA'10, Cairo, 29 November 2010 through 1 December 2010 ; 2010 , Pages 142-148 ; 9781424481354 (ISBN) Hemmati, M ; Sadati, N ; Nili, M ; Sharif University of Technology
    2010
    Abstract
    This paper deals with the problem of multi-agent learning of a population of players, engaged in a repeated normal-form game. Assuming boundedly-rational agents, we propose a model of social learning based on trial and error, called "social reinforcement learning". This extension of well-known Q-learning algorithm, allows players within a population to communicate and share their experiences with each other. To illustrate the effectiveness of the proposed learning algorithm, a number of simulations on the benchmark game of "Battle of Sexes" has been carried out. Results show that supplementing communication to the classical form of Q-learning, significantly improves convergence speed towards... 

    Improving forward solution for 2d block electrical impedance tomography using modified equations

    , Article Scientific Research and Essays ; Volume 5, Issue 11 , 2010 , Pages 1260-1263 ; 19922248 (ISSN) Abbasi, A ; Vahdat, B. V ; Sharif University of Technology
    2010
    Abstract
    Electrical impedance tomography is a simple and economic medical imaging technology which permits regional assessment of the electrical properties of organs within the body based on measurements made from electrodes on the surface of the body. Block method is a new solution for electrical impedance tomography used to enhance image resolution and to improve reconstruction algorithm. Image reconstruction by block method is an ill-posed and nonlinear problem also has memory and time consuming process which can be improved by using modified equations. Improving forward solution for block electrical impedance tomography method can make linear equations for image reconstruction algorithm