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    Electrochemical prostate-specific antigen biosensors based on electroconductive nanomaterials and polymers

    , Article Clinica Chimica Acta ; Volume 516 , 2021 , Pages 111-135 ; 00098981 (ISSN) Dowlatshahi, S ; Abdekhodaie, M. J ; Sharif University of Technology
    Elsevier B.V  2021
    Abstract
    Prostate cancer (PCa), the second most malignant neoplasm in men, is also the fifth leading cause of cancer-related deaths in men globally. Unfortunately, this malignancy remains largely asymptomatic until late-stage emergence when treatment is limited due to the lack of effective metastatic PCa therapeutics. Due to these limitations, early PCa detection through prostate-specific antigen (PSA) screening has become increasingly important, resulting in a more than 50% decrease in mortality. Conventional assays for PSA detection, such as enzyme-linked immunosorbent assay (ELISA), are labor intensive, relatively expensive, operator-dependent and do not provide adequate sensitivity.... 

    Marker-less versus marker-based driven musculoskeletal models of the spine during static load-handling activities

    , Article Journal of Biomechanics ; Volume 112 , 2020 Asadi, F ; Arjmand, N ; Sharif University of Technology
    Elsevier Ltd  2020
    Abstract
    Evaluation of workers’ body posture in workstations is a prerequisite to estimate spinal loads and assess risk of injury for the subsequent design of preventive interventions. The Microsoft Kinect™ sensor is, in this regard, advantageous over the traditional skin-marker-based optical motion capture systems for being marker-less, portable, cost-effective, and easy-to-use in real workplaces. While several studies have demonstrated the validity/reliability of the Kinect for posture measurements especially during gait trials, its capability to adequately drive a detailed spine musculoskeletal model for injury risk assessments remains to be investigated. Lumbosacral (L5-S1) load predictions of a... 

    Chaperones promote remarkable solubilization of salmonella enterica serovar enteritidis flagellin expressed in escherichia coli

    , Article Protein and Peptide Letters ; Volume 27, Issue 3 , 2020 , Pages 210-218 Bakhtiarvand, B ; Sadeghi, Z ; Tarahomjoo, S ; Yaghmaie, S ; Sharif University of Technology
    Bentham Science Publishers  2020
    Abstract
    Background: Flagellin of Salmonella enterica serovar Enteritidis (SEF) stimulates immune responses to both itself and coapplied antigens. It is therefore used in vaccine development and immunotherapy. Removal of pathogenic S. enterica ser. Enteritidis from SEF production process is advantageous due to the process safety improvement. The protein solubility analysis using SDS-PAGE indicated that 53.49% of SEF expressed in Escherichia coli formed inclusion bodies. However, the protein recovery from inclusion bodies requires a complex process with a low yield. Objective: We thus aim to study possibility of enhancing SEF expression in E. coli in soluble form using chemical and molecular... 

    On the environmental effectiveness analysis of energy policies: A case study of air pollution in the megacity of Tehran

    , Article Science of the Total Environment ; Volume 705 , 2020 Taksibi, F ; Khajehpour, H ; Saboohi, Y ; Sharif University of Technology
    Elsevier B.V  2020
    Abstract
    The present study compared different approaches to assessing the environmental cost-effectiveness of energy policy scenarios. As a case study, the megacity of Tehran in Iran was studied. A key policy challenge in this city is to curb high concentrations of PM2.5 and mitigate the associated adverse impacts. The results demonstrated that in the business as usual case, the spatially averaged primary and secondary PM2.5 concentration in Tehran will increase by 30% in the 2010–2030 period. Adopting certain planned policy scenarios and the corresponding pollutant concentration reductions in Tehran shows that although most of the emission comes from industrial activities around the city, the... 

    A simple model for various types of concretes and confinement conditions based on disturbed state concept

    , Article Scientia Iranica ; Volume 25, Issue 2A , 2018 , Pages 557-564 ; 10263098 (ISSN) Hosseinali, M ; Toufigh, V ; Sharif University of Technology
    Sharif University of Technology  2018
    Abstract
    Concrete is widely used for many practices in Civil Engineering. Therefore, an understanding of its behavior helps engineers and researchers to perform more accurate and cost-effective analyses and designs. In this respect, several models have been proposed to predict the behaviors of concrete most of which are satisfactorily accurate. However, by increasing the accuracy of the models, their computational cost increases, too. In this study, a model with the least computational cost is proposed to predict the behaviors of various concretes and confinement conditions. This model does not require any experimental tests to determine its parameters. It was proved to be able to predict the... 

    Mining the potential of label-free biosensors for in vitro antipsychotic drug screening

    , Article Biosensors ; Volume 8, Issue 1 , 2018 ; 20796374 (ISSN) Kilic, T ; Soler, M ; Fahimi Kashani, N ; Altug, H ; Carrara, S ; Sharif University of Technology
    MDPI AG  2018
    Abstract
    The pharmaceutical industry is facing enormous challenges due to high drug attribution rates. For the past decades, novel methods have been developed for safety and efficacy testing, as well as for improving early development stages. In vitro screening methods for drug-receptor binding are considered to be good alternatives for decreasing costs in the identification of drug candidates. However, these methods require lengthy and troublesome labeling steps. Biosensors hold great promise due to the fact that label-free detection schemes can be designed in an easy and low-cost manner. In this paper, for the first time in the literature, we aimed to compare the potential of label-free optical and... 

    Spatial-temporal assessment and redesign of groundwater quality monitoring network: A case study

    , Article Environmental Monitoring and Assessment ; Volume 172, Issue 1-4 , January , 2011 , Pages 263-273 ; 01676369 (ISSN) Owlia, R. R ; Abrishamchi, A ; Tajrishy, M ; Sharif University of Technology
    2011
    Abstract
    Assessment of groundwater quality monitoring networks requires methods to determine the potential efficiency and cost-effectiveness of the current monitoring programs. To this end, the concept of entropy has been considered as a promising method in previous studies since it quantitatively measures the information produced by a network. In this study, the measure of transinformation in the discrete entropy theory and the transinformation- distance (T-D) curves, which are used frequently by other researchers, are used to quantify the efficiency of a monitoring network. This paper introduces a new approach to decrease dispersion in results by performing cluster analysis that uses fuzzy... 

    Modeling, simulation, and optimal initiation planning for needle insertion into the liver

    , Article Journal of Biomechanical Engineering ; Volume 132, Issue 4 , 2010 ; 01480731 (ISSN) Sharifi Sedeh, R ; Ahmadian, M. T ; Janabi Sharifi, F ; Sharif University of Technology
    2010
    Abstract
    Needle insertion simulation and planning systems (SPSs) will play an important role in diminishing inappropriate insertions into soft tissues and resultant complications. Difficulties in SPS development are due in large part to the computational requirements of the extensive calculations in finite element (FE) models of tissue. For clinical feasibility, the computational speed of SPSs must be improved. At the same time, a realistic model of tissue properties that reflects large and velocity-dependent deformations must be employed. The purpose of this study is to address the aforementioned difficulties by presenting a cost-effective SPS platform for needle insertions into the liver. The study... 

    Multiple interactive pollutants in water quality trading

    , Article Environmental Management ; Volume 42, Issue 4 , 2008 , Pages 620-646 ; 0364152X (ISSN) Sarang, A ; Lence, B. J ; Shamsai, A ; Sharif University of Technology
    2008
    Abstract
    Efficient environmental management calls for the consideration of multiple pollutants, for which two main types of transferable discharge permit (TDP) program have been described: separate permits that manage each pollutant individually in separate markets, with each permit based on the quantity of the pollutant or its environmental effects, and weighted-sum permits that aggregate several pollutants as a single commodity to be traded in a single market. In this paper, we perform a mathematical analysis of TDP programs for multiple pollutants that jointly affect the environment (i.e., interactive pollutants) and demonstrate the practicality of this approach for cost-efficient maintenance of... 

    Determination of fentanyl in human plasma by head-space solid-phase microextraction and gas chromatography-mass spectrometry

    , Article Journal of Pharmaceutical and Biomedical Analysis ; Volume 43, Issue 5 , 2007 , Pages 1763-1768 ; 07317085 (ISSN) Bagheri, H ; Es-haghi, A ; Khalilian, F ; Rouini, M. R ; Sharif University of Technology
    2007
    Abstract
    A head-space solid-phase microextraction (HS-SPME) method coupled to GC-MS was developed to extract fentanyl from human plasma. The protein binding was reduced by acidification and, eventually, the sample was deproteinized with trichloroacetic acid. The parameters influencing adsorption (extraction time, temperature, pH and salt addition) and desorption (desorption time and temperature) of the analyte on the fibre were investigated and validated for method development. The developed method proved to be rapid, simple, easy and inexpensive and offers high sensitivity and reproducibility. Linear range was obtained from 0.1 ng/ml to 2 μg/ml. The limit of detection was 0.03 ng/ml while an... 

    A novel remote center of motion mechanism for the force-reflective master robot of haptic tele-surgery systems

    , Article International Journal of Medical Robotics and Computer Assisted Surgery ; Vol. 10, Issue. 2 , Jun , 2014 , pp. 129-139 ; ISSN: 14785951 Hadavand, M ; Mirbagheri, A ; Behzadipour, S ; Farahmand, F ; Sharif University of Technology
    Abstract
    Background: An effective master robot for haptic tele-surgery applications needs to provide a solution for the inversed movements of the surgical tool, in addition to sufficient workspace and manipulability, with minimal moving inertia. Method: A novel 4+1-DOF mechanism was proposed, based on a triple parallelogram linkage, which provided a Remote Center of Motion (RCM) at the back of the user's hand. The kinematics of the robot was analyzed and a prototype was fabricated and evaluated by experimental tests. Results: With a RCM at the back of the user's hand the actuators far from the end effector, the robot could produce the sensation of hand-inside surgery with minimal moving inertia. The... 

    A 3-D constitutive model for pressure-dependent phase transformation of porous shape memory alloys

    , Article Journal of the Mechanical Behavior of Biomedical Materials ; Volume 42 , 2015 , Pages 292-310 ; 17516161 (ISSN) Ashrafi, M. J ; Arghavani, J ; Naghdabadi, R ; Sohrabpour, S ; Sharif University of Technology
    Abstract
    Porous shape memory alloys (SMAs) exhibit the interesting characteristics of porous metals together with shape memory effect and pseudo-elasticity of SMAs that make them appropriate for biomedical applications. In this paper, a 3-D phenomenological constitutive model for the pseudo-elastic behavior and shape memory effect of porous SMAs is developed within the framework of irreversible thermodynamics. Comparing to micromechanical and computational models, the proposed model is computationally cost effective and predicts the behavior of porous SMAs under proportional and non-proportional multiaxial loadings. Considering the pressure dependency of phase transformation in porous SMAs, proper...