Sharif Digital Repository

Recent advances in the field of microfabrication have made the application of high-throughput microfluidics feasible. Mixing which is an essential part of any miniaturized standalone system remains the key challenge. This paper proposes a geometrically simple micromixer for efficient mixing for high-throughput microfluidic devices. The proposed micromixer utilizes a curved microchannel (spiral microchannel) to induce chaotic advection and enhance the mixing process. It is shown that the spiral microchannel is more efficient in comparison to a straight microchannel, mixing wise. The pressure drop in the spiral microchannel is only slightly higher than that in the straight microchannel. It is... 

A novel method involving focusing of magnetic particles at the inner wall of a curved microchannel and secondary Dean flow-based exchange of their fluid was investigated. Solution exchange occurred in a hybrid microchip at very high throughput and with unprecedented solution exchange and particle isolation efficiencies of 99.2% and 90%, respectively. © 17CBMS-0001  

Since the discovery of inertial focusing in 1961, numerous theories have been put forward to explain the migration of particles in inertial flows, but a complete understanding is still lacking. Recently, computational approaches have been utilized to obtain better insights into the underlying physics. In particular, fundamental aspects of particle focusing inside straight and curved microchannels have been explored in detail to determine the dependence of focusing behavior on particle size, channel shape, and flow Reynolds number. In this review, we differentiate between the models developed for inertial particle motion on the basis of whether they are semi-analytical, Navier-Stokes-based,...