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Neuronal cell navigation within a microfluidic device
, Article Middle East Conference on Biomedical Engineering, MECBME ; 17-20 February , 2014 , pp. 261-264 ; Sharif University of Technology
Abstract
In this study, the polarization and navigation of neuronal cells was studied in response to quantified gradients of nerve growth factor (NGF). To accomplish this, a microfluidic device was designed and fabricated to generate stable concentration gradients of biomolecules in a cell culture chamber within a 3D microenvironment. Numerical simulation was implemented to optimize the device geometry for generating a uniform concentration gradient of NGF which was found to remain stable for multiple hours. Neural Stem/ Progenitor Cell (NSCs) migration and differentiation was studied within this microfluidic device in response to NGF concentration and within a 3D environment of collagen matrix....
Behavior of tilted angle shear connectors
, Article PLoS ONE ; Volume 10, Issue 12 , December , 2015 ; 19326203 (ISSN) ; Maleki, S ; Shariati, M ; Ramli Sulong, N. H ; Sharif University of Technology
Public Library of Science
2015
Abstract
According to recent researches, angle shear connectors are appropriate to transfer longitudinal shear forces across the steel-concrete interface. Angle steel profile has been used in different positions as L-shaped or C-shaped shear connectors. The application of angle shear connectors in tilted positions is of interest in this study. This study investigates the behaviour of tilted-shaped angle shear connectors under monotonic loading using experimental push out tests. Eight push-out specimens are tested to investigate the effects of different angle parameters on the ultimate load capacity of connectors. Two different tilted angles of 112.5 and 135 degrees between the angle leg and steel...
Numerical simulation of mixing and heat transfer in an integrated centrifugal microfluidic system for nested-PCR amplification and gene detection
, Article Sensors and Actuators, B: Chemical ; Volume 283 , 2019 , Pages 831-841 ; 09254005 (ISSN) ; Ghazimirsaeed, E ; Shamloo, A ; Sharif University of Technology
Elsevier B.V
2019
Abstract
Nucleic acid amplification via polymerase chain reaction (PCR) is one of the essential and powerful methods used in a myriad of bio-assays in clinical laboratories. Application of microfluidic devices in biologically-related processes like PCR can result in the usage of less volume of reactant samples and reduce the processing time. By implementing PCR systems on centrifugal microfluidic platforms, automation and portability can be easily achieved. Although several methods have been developed, most of them are still dealing with challenges of the required high processing time. This study presents the numerical simulation of a fully automated PCR system with the goal of enhancing the mixing...
A comparison of different geometrical elements to model fluid wicking in paper-based microfluidic devices
, Article AIChE Journal ; Volume 66, Issue 1 , 2020 ; Shamloo, A ; Sharif University of Technology
John Wiley and Sons Inc
2020
Abstract
Recently, microfluidic paper-based analytical devices (μPADs) have outstripped polymeric microfluidic devices in the ease of fabrication and simplicity. Surface tension-based fluid motion in the paper's porous structure has made the paper a suitable substrate for multiple biological assays by directing fluid into multiple assay zones. The widespread assumption in most works for modeling wicking in a paper is that the paper is a combination of capillaries with the same diameter equal to the effective pore diameter. Although assuming paper as a bundle of capillaries gives a good insight into pressure force that drives the fluid inside the paper, there are some difficulties using the effective...
Computational study of geometric effects of bottom wall microgrooves on cell docking inside microfluidic devices
, Article Journal of Mechanics in Medicine and Biology ; Volume 21, Issue 2 , 2021 ; 02195194 (ISSN) ; Saadatmand, M ; Sharif University of Technology
World Scientific
2021
Abstract
Cells docking inside microfluidic devices is effective in studying cell biology, cell-based biosensing, as well as drug screening. Furthermore, single cell and regularly cells docking inside the microstructure of microfluidic systems are advantageous in different analyses of single cells exposed to equal drug concentration and mechanical stimulus. In this study, we investigated bottom wall microgrooves with semicircular and rectangular geometries with different sizes which are suitable for single cell docking along the length of the microgroove in x-direction and numerous cells docking regularly in one line inside the microgroove in a 3D microchannel. We used computational fluid dynamics to...
Computational study of geometric effects of bottom wall microgrooves on cell docking inside microfluidic devices
, Article Journal of Mechanics in Medicine and Biology ; Volume 21, Issue 2 , 2021 ; 02195194 (ISSN) ; Saadatmand, M ; Sharif University of Technology
World Scientific
2021
Abstract
Cells docking inside microfluidic devices is effective in studying cell biology, cell-based biosensing, as well as drug screening. Furthermore, single cell and regularly cells docking inside the microstructure of microfluidic systems are advantageous in different analyses of single cells exposed to equal drug concentration and mechanical stimulus. In this study, we investigated bottom wall microgrooves with semicircular and rectangular geometries with different sizes which are suitable for single cell docking along the length of the microgroove in x-direction and numerous cells docking regularly in one line inside the microgroove in a 3D microchannel. We used computational fluid dynamics to...