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dopamine
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The effects of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) on the cognitive and motor functions in rodents: A systematic review and meta-analysis
, Article Neuroscience and Biobehavioral Reviews ; Volume 140 , 2022 ; 01497634 (ISSN) ; Abbaszadeh, M ; Ghazizadeh, A ; Sharif University of Technology
Elsevier Ltd
2022
Abstract
Memory and motor deficits are commonly identified in Parkinson's disease (PD). 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) is transformed to MPP+ via monoamine oxidase B (MAOB), which causes oxidative stress and destroys dopaminergic (DA) neurons in substantia nigra pars compacta (SNc) and is widely used to create animal models of PD. However, to-date, a comprehensive analysis of the MPTP effects on various aspects of PD does not exist. Here, we provide a systematic review and meta-analysis on the MPTP effects on memory and motor functions by analyzing 51 studies on more than one thousand animals mainly including rats and mice. The results showed that in addition to motor functions...
Reduced polydopamine coated graphene for delivery of Hset1 antisense as A photothermal and gene therapy of breast cancer
, Article Journal of Drug Delivery Science and Technology ; Volume 73 , 2022 ; 17732247 (ISSN) ; Tekie, F. S. M ; Ayazi, H ; Ranjbar, S ; Varshochian, R ; Rad-Malelkshahi, M ; Akhavan, O ; Dinarvand, R ; Sharif University of Technology
Editions de Sante
2022
Abstract
Breast cancer is the most prevalent type of cancer in women; hence, many researches have been focused on developing effective treatment protocols. In this study, a novel nanocarrier was fabricated for gene and photothermal combination cancer therapy by conjugating histone methyltransferase complex subunit SET1 (hSET1) on reduced polydopamine coated graphene oxide nanosheets (rGO-PDA). The rGO-PDA nanocarriers provide higher near-infrared absorption and further integrating with hSET1 antisense as an anticancer gene that down-regulates the amount of hSET1 overexpressed and suppresses the proliferation of cancer cells. The nanoplatform was prepared by polymerizing of dopamine, a mussel adhesive...
Dopamine receptors gene expression pattern and locomotor improvement differ between female and male zebrafish during spinal cord auto repair
, Article Zebrafish ; Volume 19, Issue 4 , 2022 , Pages 137-147 ; 15458547 (ISSN) ; Mirsadeghi, S ; Rahmani, S ; Izadi, A ; Rezaei, M ; Ghodsi, Z ; Rahimi Movaghar, V ; Kiani, S ; Sharif University of Technology
Mary Ann Liebert Inc
2022
Abstract
The dopaminergic system, a spinal cord (SC) motor circuit regulator, is administrated by sexual hormones and evolutionary conserved in all vertebrates. Accordingly, we hypothesized that the dopamine receptor (DAR) expression pattern may be dissimilar in female and male zebrafish SC auto repair. We implemented an uncomplicated method to induce spinal cord injury (SCI) on fully reproductive adult zebrafish, in both genders. SCI was induced using a 28-gauge needle at 9th-10th vertebra without skin incision. Thereupon, lesioned SC was harvested for DAR gene expression analysis; zebrafish were tracked routinely for any improvement in swim distance, speed, and their roaming...
Detection of dopamine receptors using nanoscale dendrimer for potential application in targeted delivery and whole-body imaging: synthesis and in vivo organ distribution
, Article ACS Applied Bio Materials ; Volume 5, Issue 4 , 2022 , Pages 1744-1755 ; 25766422 (ISSN) ; Aminzadeh Jahromi, N ; Ali, V ; Ebrahimpour, A ; Salehian, E ; Shafiee Ardestani, M ; Seyedhamzeh, M ; Ahmadi, S ; Sharifi, E ; Ashrafizadeh, M ; Rabiee, N ; Makvandi, P ; Sharif University of Technology
American Chemical Society
2022
Abstract
Dopamine is one of the most important neurotransmitters released by neurons in the central nervous system, and a variety of neurological illnesses and mental disorders are associated with impairments in the secretion and functionality of dopamine. Dopamine, depending on the type of receptors, can act as a stimulant or an inhibitor. In this study, dendrimer-conjugated dopamine was utilized as a chelating agent for Technetium-99m to investigate the organ distribution of this compound in vivo using the single-photon emission computed tomography (SPECT) technique. For this purpose, dendrimers were synthesized using polyethylene glycol diacid and citric acid precursors, and dopamine was...
Effectively exerting the reinforcement of polyvinyl alcohol nanocomposite hydrogel via poly(dopamine) functionalized graphene oxide
, Article Composites Science and Technology ; Volume 217 , 2022 ; 02663538 (ISSN) ; Pircheraghi, G ; Nazockdast, H ; Sharif University of Technology
Elsevier Ltd
2022
Abstract
Nature-inspired coating with polydopamine (PDA) is a promising way to improve the performance of graphene oxide (GO) based nanocomposites due to its high ability to enhance interactions in matrix-disperse systems. Here, we examined the capability of two types of PDA to develop the reinforced polyvinyl alcohol (PVA)/GO hydrogels. In the first mode, dopamine hydrochloride was polymerized as nanoparticles and then incorporated into PVA solution with GO nanoplatelets (P-NG hydrogel). In the second mode, polydopamine was polymerized in the presence of GO nanoparticles to obtain PDA surface-modified GO and then PVA nanocomposite hydrogel (P-CG sample). Rheological and tensile findings revealed...
Graphene-based nanomaterials in fighting the most challenging viruses and immunogenic disorders
, Article ACS Biomaterials Science and Engineering ; Volume 8, Issue 1 , 2022 , Pages 54-81 ; 23739878 (ISSN) ; Asadi, M ; Akhavan, O ; Sharif University of Technology
American Chemical Society
2022
Abstract
Viral diseases have long been among the biggest challenges for healthcare systems around the world. The recent Coronavirus Disease 2019 (COVID-19) pandemic is an example of how complicated the situation can get if we are not prepared to combat a viral outbreak in time, which brings up the need for quick and affordable biosensing platforms and vast knowledge of potential antiviral effects and drug/gene delivery opportunities. The same challenges have also existed for nonviral immunogenic disorders. Nanomedicine is considered a novel candidate for effectively overcoming these worldwide challenges. Among the versatile nanomaterials commonly used in biomedical applications, graphene has recently...
Anxiety and cognitive load affect upper limb motor control in Parkinson's disease during medication phases
, Article Annals of the New York Academy of Sciences ; Volume 1494, Issue 1 , 2021 , Pages 44-58 ; 00778923 (ISSN) ; Mehdizadeh, H ; Azad, A ; Mehdizadeh, M ; Reyhanian, E ; Saberi, Z. S ; Meimandi, M ; Soltanzadeh, A ; Roohi Azizi, M ; Vasaghi Gharamaleki, B ; Parnianpour, M ; Khalaf, K ; Taghizadeh, G ; Sharif University of Technology
John Wiley and Sons Inc
2021
Abstract
Anxiety is among the most debilitating nonmotor symptoms of Parkinson's disease (PD). This study aimed to determine how PD patients with low and high levels of anxiety (LA-PD and HA-PD, respectively) compare with age- and sex-matched controls at the level of motor control of reach-to-grasp movements during single- and dual-task conditions with varying complexity. Reach-to-grasp movement kinematics were assessed in 20 LA-PD, 20 HA-PD, and 20 sex- and age-matched healthy controls under single- as well as easy and difficult dual-task conditions. Assessment of PD patients was performed during both the on- and off-drug phases. The results obtained during dual-task conditions reveal deficits in...
A smartphone-based fluorescent electronic tongue for tracing dopaminergic agents in human urine
, Article ACS Chemical Neuroscience ; Volume 12, Issue 17 , 2021 , Pages 3157-3166 ; 19487193 (ISSN) ; Bigdeli, A ; Hormozi Nezhad, M. R ; Sharif University of Technology
American Chemical Society
2021
Abstract
The importance of tracing dopaminergic agents in the progression assessment of Parkinson's disease has boosted the demand for fast, sensitive, and real-time multi-analyte detection. Herein, visual and fingerprint fluorimetric patterns have been created by an optical sensor array to simultaneously detect and discriminate among levodopa, carbidopa, benserazide, and entacapone, as important dopaminergic agents. A dual emissive nanoprobe consisting of red quantum dots and blue carbon dots with an overall pink emission has been fabricated to provide unique emission patterns in the presence of the target analytes. The sensor elements in the array come from it's differential response in the absence...
Comparison between electrochemical and photoelectrochemical detection of dopamine based on titania-ceria-graphene quantum dots nanocomposite
, Article Biosensors and Bioelectronics ; Volume 151 , 2020 ; Bagherzadeh, M ; Nemati, A ; Sharif University of Technology
Elsevier Ltd
2020
Abstract
In this study, titania-ceria-graphene quantum dot (TC-GQD) nanocomposite was synthesized by hydrothermal method for the first time. The prepared nanomaterials were characterized by XRD, FTIR dynamic light scattering (DLS), FESEM, HRTEM, and EDX spectroscopy along with elemental mapping. The synergistic effect of the nanocomposite components was studied by diffuse reflectance spectroscopy (DRS) and electrical conductivity meter. The results showed that band gap of TC-GQD nanocomposite was shifted to visible lights relative to its components (1.3 eV), and electrical conductivity of the sample was significant increased to 89.5 μS cm−1. After chemical and physical characterization, prepared new...
Identification of catecholamine neurotransmitters using a fluorescent electronic tongue
, Article ACS Chemical Neuroscience ; Volume 11, Issue 1 , November , 2020 , Pages 25-33 ; Bigdeli, A ; Ghazi Khansari, M ; Sasanpour, P ; Hormozinezhad, M. R ; Sharif University of Technology
American Chemical Society
2020
Abstract
Catecholamine neurotransmitters, specifically, dopamine (DA), epinephrine (EP), and norepinephrine (NE), are known as substantial indicators of various neurological diseases. Developing rapid detection methods capable of simultaneously screening their concentrations is highly desired for early clinical diagnosis of such diseases. To this aim, we have designed an optical sensor array using three fluorescent dyes with distinct emission bands and have monitored variations in their emission profiles upon the addition of DA, EP, and NE in the presence of gold ions. Because of the different reducing power of catecholamines, differently sized gold nanoparticles (GNPs) with different levels of...
Burgeoning polymer nano blends for improved controlled drug release: A review
, Article International Journal of Nanomedicine ; Volume 15 , March , 2020 , Pages 4363-4392 ; Shahraki, B. T ; Rabiee, N ; Fatahi, Y ; Dinarvand, R ; Tavakolizadeh, M ; Ahmadi, S ; Rabiee, M ; Bagherzadeh, M ; Pourjavadi, A ; Farhadnejad, H ; Tahriri, M ; Webster, T. J ; Tayebi, L ; Sharif University of Technology
Dove Medical Press Ltd
2020
Abstract
With continual rapid developments in the biomedical field and understanding of the important mechanisms and pharmacokinetics of biological molecules, controlled drug delivery systems (CDDSs) have been at the forefront over conventional drug delivery systems. Over the past several years, scientists have placed boundless energy and time into exploiting a wide variety of excipients, particularly diverse polymers, both natural and synthetic. More recently, the development of nano polymer blends has achieved noteworthy attention due to their amazing properties, such as biocompatibility, biodegradability and more importantly, their pivotal role in controlled and sustained drug release in vitro and...
Laccase activity assay using surface plasmon resonance band of gold nanoparticles formed by dopamine
, Article Plasmonics ; Volume 13, Issue 4 , 2018 , Pages 1409-1415 ; 15571955 (ISSN) ; Hormozi Nezhad, M. R ; Akhond, M ; Absalan, G ; Sharif University of Technology
Springer New York LLC
2018
Abstract
A simple, fast, and sensitive colorimetric technique for determination of laccase activity using dopamine (DA) induced growth of colloidal gold nanoparticles is proposed. It was found that the reduction of AuCl4 − to colloidal gold nanoparticles (AuNPs) by dopamine (DA) in the presence of citrate ion as stabilizing agent produced a very intense surface plasmon resonance peak of AuNPs at 530 nm. As the activity of laccase (at fixed concentration of DA) increases, the oxidation of DA to dopamine-o-quinone (DOQ) is enhanced. The latter product could not act as the reducing agent for the reduction of AuCl4 − to AuNPs. So, as the activity of laccase increases, the absorbance characteristic to the...
Mining the potential of label-free biosensors for in vitro antipsychotic drug screening
, Article Biosensors ; Volume 8, Issue 1 , 2018 ; 20796374 (ISSN) ; Soler, M ; Fahimi Kashani, N ; Altug, H ; Carrara, S ; Sharif University of Technology
MDPI AG
2018
Abstract
The pharmaceutical industry is facing enormous challenges due to high drug attribution rates. For the past decades, novel methods have been developed for safety and efficacy testing, as well as for improving early development stages. In vitro screening methods for drug-receptor binding are considered to be good alternatives for decreasing costs in the identification of drug candidates. However, these methods require lengthy and troublesome labeling steps. Biosensors hold great promise due to the fact that label-free detection schemes can be designed in an easy and low-cost manner. In this paper, for the first time in the literature, we aimed to compare the potential of label-free optical and...
Molecularly imprinted polydopamine nano-layer on the pore surface of porous particles for protein capture in HPLC column
, Article Journal of Colloid and Interface Science ; Volume 404 , 2013 , Pages 117-126 ; 00219797 (ISSN) ; Shojaei, A ; Abdekhodaie, M. J ; Sellergren, B ; Sharif University of Technology
2013
Abstract
Bio-inspired Human Serum Albumin (HSA) imprinted polydopamine nano-layer was produced through oxidative polymerization of dopamine on the pore surface of HSA modified porous silica particles. The coating thickness was controlled by the reaction time and thereby varied within 0-12. nm. The samples were characterized by elemental analysis, FT-IR, DSC, SEM, TEM, TGA, physisorption and thermoporometry. The characterization confirmed the success of evolution and deposition of polydopamine layer on the silica pore surface. Batch rebinding experiment showed that the molecularly imprinted polymer (MIP) with 8.7. nm coating thickness, in comparison with the thinner and thicker coatings, displays the...
Sensitive determination of dopamine in the presence of uric acid and ascorbic acid using TiO2 nanotubes modified with Pd, Pt and Au nanoparticles
, Article Analyst ; Volume 136, Issue 11 , 2011 , Pages 2322-2329 ; 00032654 (ISSN) ; Li, C ; Mahshid, S. S ; Askari, M ; Dolati, A ; Yang, L ; Luo, S ; Cai, Q ; Sharif University of Technology
2011
Abstract
A simple modified TiO2 nanotubes electrode was fabricated by electrodeposition of Pd, Pt and Au nanoparticles. The TiO2 nanotubes electrode was prepared using the anodizing method, followed by modifying Pd nanoparticles onto the tubes surface, offering a uniform conductive surface for electrodeposition of Pt and Au. The performance of the modified electrode was characterized by cyclic voltammetry and differential pulse voltammetry methods. The Au/Pt/Pd/TiO2 NTs modified electrode represented a high sensitivity towards individual detection of dopamine as well as simultaneous detection of dopamine and uric acid using 0.1 M phosphate buffer solution (pH 7.00) as the base solution. In both case,...
Speed/accuracy trade-off between the habitual and the goal-directed processes
, Article PLoS Computational Biology ; Volume 7, Issue 5 , 2011 ; 1553734X (ISSN) ; Dezfouli, A ; Piray, P ; Sharif University of Technology
2011
Abstract
Instrumental responses are hypothesized to be of two kinds: habitual and goal-directed, mediated by the sensorimotor and the associative cortico-basal ganglia circuits, respectively. The existence of the two heterogeneous associative learning mechanisms can be hypothesized to arise from the comparative advantages that they have at different stages of learning. In this paper, we assume that the goal-directed system is behaviourally flexible, but slow in choice selection. The habitual system, in contrast, is fast in responding, but inflexible in adapting its behavioural strategy to new conditions. Based on these assumptions and using the computational theory of reinforcement learning, we...
Individual differences in nucleus accumbens dopamine receptors predict development of addiction-like behavior: A computational approach
, Article Neural Computation ; Volume 22, Issue 9 , 2010 , Pages 2334-2368 ; 08997667 (ISSN) ; Keramati, M. M ; Dezfouli, A ; Lucas, C ; Mokri, A ; Sharif University of Technology
2010
Abstract
Clinical and experimental observations show individual differences in the development of addiction. Increasing evidence supports the hypothesis that dopamine receptor availability in the nucleus accumbens (NAc) predisposes drug reinforcement. Here, modeling striatal-midbrain dopaminergic circuit, we propose a reinforcement learning model for addiction based on the actor-critic model of striatum. Modeling dopamine receptors in the NAc as modulators of learning rate for appetitive-but not aversive-stimuli in the critic-but not the actor-we define vulnerability to addiction as a relatively lower learning rate for the appetitive stimuli, compared to aversive stimuli, in the critic. We...
Voltammetric determination of dopamine at the surface of TiO2 nanoparticles modified carbon paste electrode
, Article International Journal of Electrochemical Science ; Volume 5, Issue 1 , 2010 , Pages 147-157 ; 14523981 (ISSN) ; Rajabi, H ; Beitollahi, H ; Mirjalili, B.B.F ; Akbari, A ; Taghavinia, N ; Sharif University of Technology
2010
Abstract
In the present paper, the use of a novel carbon paste electrode modified by N,N'(2,3-dihydroxybenzylidene)-1,4-phenylenediamine (DHBPD) and TiO2 nanoparticles prepared by a simple and rapid method for the determination of dopamine (DA) was described. In the first part of the work, cyclic voltammetry was used to investigate the redox properties of this modified electrode at various solution pH values and at various scan rates. A linear segment was found with slope value of about 48 mV/pH in the pH range 2.0 -12.0. The apparent charge transfer rate constant (ks) and transfer coefficient (α) for electron transfer between DHBPD and TiO2 nanoparticles-carbon paste electrode were calculated. In...
Electrochemical synthesis of polypyrrole in the presence of congo red; application to selective voltammetric determination of dopamine in the presence of ascorbic acid
, Article Electroanalysis ; Volume 21, Issue 2 , 2009 , Pages 157-164 ; 10400397 (ISSN) ; Zare Mehrjardi, H. R ; Sharif University of Technology
2009
Abstract
The electrosynthesis of polypyrrole (PPy) film has been achieved on glassy carbon electrode (GCE) in aqueous medium of Congo red (CR) by means of cyclic voltammetry (CV). The modified electrode exhibits high electrocatalytic activity toward dopamine (DA) oxidation, with drastic enhancement of the reversibility and peak currents. This modified electrode, due to electrostatic interactions, is capable to mask the response of ascorbic acid (AA) completely and provide an effective method for the detection of minor amounts of dopamine in the presence of high concentrations of AA. The electrochemical response of the film modified electrode is strongly dependent to the switching potential applied in...
Fabrication of modified TiO 2 nanoparticle carbon paste electrode for simultaneous determination of dopamine, uric acid, and l-cysteine
, Article Journal of Solid State Electrochemistry ; Volume 13, Issue 9 , 2009 , Pages 1433-1440 ; 14328488 (ISSN) ; Talebi, A ; Naeimi, H ; Nejati Barzoky, M ; Taghavinia, N ; Sharif University of Technology
2009
Abstract
A carbon paste electrode, modified with 2, 2″-[1,7- hepthandiylbis(nitriloethylidyne)]-bis-hydroquinone and TiO 2 nanoparticles, was used for the simultaneous determination of dopamine (DA), uric acid (UA), and l-cysteine. The study was carried out by using cyclic voltammetry, chronoamperometry, and square wave voltammetry (SWV) techniques. Some kinetic parameters such as the electron transfer coefficient (α) and heterogeneous rate constant (k s) were also determined for the DA oxidation. A dynamic range of 8.0-1400 μM, with the detection limit of 8.4∈×∈10 -7 M for DA, was obtained using SWV (pH∈=∈7.0). The prepared electrode was successfully applied for the determination of DA, UA, and...