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Facile design of autogenous stimuli-responsive chitosan/hyaluronic acid nanoparticles for efficient small molecules to protein delivery
, Article Journal of Materials Chemistry B ; Volume 8, Issue 32 , 2020 , Pages 7275-7287 ; Ji, J ; Lotocki, V ; Moquin, A ; Hanna, R ; Frounchi, M ; Maysinger, D ; Kakkar, A ; Sharif University of Technology
Royal Society of Chemistry
2020
Abstract
Easily assembled and biocompatible chitosan/hyaluronic acid nanoparticles with multiple stimuli-responsive ability are ideally suited for efficient delivery of therapeutic agents under specific endogenous triggers. We report a simple and versatile strategy to formulate oxidative stress and pH-responsive chitosan/hyaluronic acid nanocarriers with high encapsulation efficiencies of small drug molecules and nerve growth factor protein. This is achieved through invoking the dual role of a thioketal-based weak organic acid to disperse and functionalize low molecular weight chitosan in one-pot. Thioketal embedded chitosan/hyaluronic acid nanostructures respond to oxidative stress and show...