Loading...
Search for:
drug-delivery
0.014 seconds
Total 356 records
Robust Optimal Control of Drug Delivery in Cancer Chemotherapy based on a New Realistic Dynamic Model of the Process
, M.Sc. Thesis Sharif University of Technology ; Moradi, Hamed (Supervisor)
Abstract
Today, cancer mortality is one of the most important problems, even considering the scientific advances that offer more effective solutions to treat some diseases, providing a way to prevent and treat this disease is one of the most important issues that engineers have considered. This is achieved by designing a controller to minimize the size of the cancer tumor population, increase healthy cells, optimize treatment time, and drug dose.To achieve this goal, pharmacokinetic, pharmacodynamic, tumor growth, and healthy cell growth models, and mathematical models for subsystems that affect tumor growth, such as the angiogenic system, have been studied to develop a single mathematical model. In...
Nonlinear Adaptive Control of Treatment in a Basic Hepatitis B Virus Infection Model in the Presence of Uncertainties
, M.Sc. Thesis Sharif University of Technology ; Zohour, Hassan (Supervisor)
Abstract
Hepatitis B is an infectious disease caused by the hepatitis B virus (HBV) which affects the liver. Several dynamic models have been developed to mathematically describe the HBV infection and antiviral therapy. In this thesis, a nonlinear adaptive control strategy is developed for the treatment of the Hepatitis B Virus (HBV) infection inside a body. The considered nonlinear HBV model has three state variables, the numbers of uninfected and infected cells and free viruses. The proposed control law is designed for the antiviral drug input such that the number of free viruses per unit volume of the blood and consequently the number of infected cells decrease to some desired values. The...
کلیدواژه های تکراریCurcumin loading potentiates the neuroprotective efficacy of Fe3O4 magnetic nanoparticles in cerebellum cells of schizophrenic rats
, Article Biomedicine and Pharmacotherapy ; Volume 108 , 2018 , Pages 1244-1252 ; 07533322 (ISSN) ; Ashrafi Hafez, A ; Abdorahim, M ; Abdollahifar, M. A ; Shabani, R ; Peirovi, H ; Simchi, A ; Ashtari, K ; Sharif University of Technology
Abstract
Background: The aim of this study was to investigate the neurotoxic effects of Fe3O4 magnetic- CurNPs on isolated schizophrenia mitochondria of rats as an in vivo model. Methods: We designed CMN loaded superparamagnetic iron oxide nanoparticles (SPIONs) (Fe3O4 magnetic- CurNPs) to achieve an enhanced therapeutic effect. The physicochemical properties of Fe3O4 magnetic- CurNPs were characterized using X-ray diffraction (XRD), and dynamic laser light scattering (DLS) and zeta potential. Further, to prove Fe3O4 magnetic- CurNPs results in superior therapeutic effects, and also, the mitochondrial membrane potential collapse, mitochondrial complex II activity, reactive oxygen species generation,...
PEG-PLA-Polysccharide Injectable Nanogels for Drug Delivery
, M.Sc. Thesis Sharif University of Technology ; Frounchi, Masoud (Supervisor) ; Dadbin, Sousan (Supervisor)
Abstract
In recent years along with time and cost intensive process of developing new and better drugs for diseases like cancer, scientists and researchers are attempting to develop novel drug delivery systems for already existing drugs.The purpose of these novel drug delivery systems such as nanogels is controlling drug release rate as well as delivery to a specific target tissue in order to reduce side effects. One of the most commonly used drugs for cancer treatment is Doxorubicin HCl, commercially known as Adricin. In this project biodegradable and biocompatible polymers PLA and PEG were used to synthesize nanocarriers for Adricin. These nanocarriers were then dispersed in an agar hydrogel. The...
Comparing Effects of Natural Antibiotics and Anti Bacterial Materials in Burn Wound Infections with Nanoparticles and Skin Scaffold
, M.Sc. Thesis Sharif University of Technology ; Alemzadeh, Iran (Supervisor) ; Vosoughi, Manouchehr (Supervisor)
Abstract
Burns are one of the most important accidents related to human health. Due to the intense physical and mental complications and high fatality rate associated with them, receiving proper treatment is of paramount importance. The control of infection in wounds would cure and eliminates the effect of wounds and treatment of skin lesions with engineered scaffolds can be an effective method. The purpose of this project is proposing a hydrogel scaffold based on natural polymers of oxidized alginate and gelatin loaded with an herbal drug to control infection and treat burn wounds. For this purpose, the Iranian Oak extract that it's main content is Tanin and PolyPhenolinc materials, was prepared and...
Study and Synthesis of Biocompatible Polymer and Loading of Peptide Drug for using in Drug Delivery
, M.Sc. Thesis Sharif University of Technology ; Vosoughi, Manouchehr (Supervisor) ; Alemzadeh, Iran (Co-Advisor)
Abstract
With the rapid development of biotechnology, peptide and protein drugs are now playing an increasingly important role in therapeutics. Compared with chemical drugs, peptide and protein drugs have some limitations such as low stability and rapid deactivation. Biodegradable and biocompatible polymeric micro carriers have been shown to have a high potential for the delivery of peptides and proteins. Among these polymers, alginate has been widely investigated as a biomaterial. Alginates are natural polysaccharide polymers isolated from brown seaweed. Bovine serum albumin (BSA) loaded calcium alginate microspheres produced in this study by a modified w/o emulsification method. The influence of...
Study and Fabrication of a Multilayer Scaffold Containing Biological Agents for Skin Wounds Regeneration
, Ph.D. Dissertation Sharif University of Technology ; Alemzadeh, Iran (Supervisor) ; Vossoughi, Manouchehr (Supervisor) ; Shamloo, Amir (Co-Supervisor)
Abstract
In recent years, it is expected that the fabrication of multilayer scaffolds and the use of different methodologies in one product can be a new progressing method in skin substitute production. Accordingly, this project aims to fabricate a bilayered composite scaffold with a combination of hydrogel and electrospinning method. We have tried to prepare a scaffold made of oxidized alginate (OAL), gelatin (G), and silk fibroin (SF) without using corrosive solvents and toxic crosslinking agents as a scaffold and drug delivery system. As different biological, chemical, physical, and mechanical factors play a vital role in the healing process, we have characterized the proposed scaffold via DSC,...
Fabricate of Novel Drug Vector Based on Metallic Nanoparticles and Study of its Effects on Cell Line
, Ph.D. Dissertation Sharif University of Technology ; Vosoughi, Manouchehr (Supervisor) ; Alemzadeh, Iran (Supervisor)
Abstract
Application of nanoparticles in targeted delivery and controlled drug release is recently highly attracted especially in cancer therapy. In this study with the aim of developing a novel drug vector based on metallic nanoparticles, gold nanoparticles with their unique characteristics were used to design a vector for targeted anti-cancer drug delivery to tumor. First, gold nanoparticles were chemically synthesized therough sodium citrate and sodium brohydrate reductions with average diameters of 22 and 11 nm, respectively. Then, the activated poly ethylene glycol (PEG) and activated folic acid were conjugated to the lysine-capped gold nanoparticles. Subsequently, the widely used anticancer...
An Experimental Study of Cancer Treatment Using Combined Hyperthermia and Chemotherapy Methods
, Ph.D. Dissertation Sharif University of Technology ; Vosoghi, Manoucher (Supervisor) ; Hormozinezhad, Mohammad Reza (Supervisor) ; Dinarvand, Rasoul (Supervisor) ; Iraji Zad, Azam (Co-Advisor)
Abstract
Cancer treatment is one of the most challenging issues of recent years. Extensive researches have been conducted in various fields of medicine, pharmacy, and medical physics in this regard. Today, considering nanotechnology developments, researchers believe that full cancer treatment is possible through the use of nano-systems designed with scientific background to overcome the defects of previous methods. In this research, the main purpose is to design and synthesize multifunctional hybrid nanostructures with favorable optical and magnetic properties providing a way to combine chemotherapy and thermal treatment. Accordingly, two different structures were designed and experimentally...
Some Studies on Conjugation of Nanoparticles Fe3O4 (Fe2O3) to PEG for Drug Delivery Systems
, M.Sc. Thesis Sharif University of Technology ; Vossoughi, Manouchehr (Supervisor) ; Yaghmaei, Soheila (Supervisor)
Abstract
The main strategy for treating solid cancers is based on the very early diagnosis of a malignant tumor, and in general the smaller the tumor, the greater the likelihood of successful treatment. Magnetic Resonance Imaging (MRI), based on the nuclear magnetic resonance phenomenon, provides the possibility of detecting early malignant tumors with the assistance of appropriate contrast agents. Hence, researchers continue to develop novel magnetic materials to achieve this aim. Superparamagnetic nanoparticles have become the focus of these studies because their superparamagnetic, biocompatible and hydrophilic properties would be revealed after modifying the particle surface by suitable...
Numerical Study of Margination and Adhesion of Micro- and Nano-particles in Coronary Circulation
, M.Sc. Thesis Sharif University of Technology ; Shamloo, Amir (Supervisor)
Abstract
Obstruction of Left Anterior Descending artery (LAD) due to thrombosis or atherosclerotic plaques is the leading cause of death world–wide. Targeted delivery of drugs through micro- Nano-particles holds noteworthy promise which can make clot busting or the restenosis treatment with minimal toxicity possible. In this work, Fluid-Structure Interaction (FSI) simulations of blood flow through a patient-specific reconstructed geometry of LAD artery have been conducted using a non-Newtonian hematocrit (HCT) dependent model for blood. Based on physiological facts, 25, 45 and 65 percentages of HCT were assumed as acceptable representations of anemic, healthy and diabetic blood conditions,...
In Vitro Study of Drug Release from the Metal-organic Frameworks (MOFs) for Melanoma Cancer Drug Delivery
, Ph.D. Dissertation Sharif University of Technology ; Vossoughi, Manouchehr (Supervisor) ; Bagherzadeh, Mojtaba (Supervisor) ; Pooshang Bagheri, Kamran (Co-Supervisor)
Abstract
Metal-organic frameworks (MOFs) are a new class of biocompatible nanomaterials with high specific surface area, which provide the possibility of loading various therapeutic agents. Considering the few studies on the use of MOFs in melanoma cancer treatment, the main goal of this research is to investigate the loading and controlling the release of dacarbazine (DTIC) and also the interaction of DTIC and MOF structure in aqueous environments. Based on this, this study was done in three main parts. In the first part, several types of well-known and often used structures in the drug delivery field, including ZIF-8 (based on zinc), MIL-101-NH2(Fe), and MIL-100(Fe) (both based on iron), were...
Design and Fabrication of Microfluidic System to Produce Microgel for Drug Delivery Application
, M.Sc. Thesis Sharif University of Technology ; Bastani, Dariush (Supervisor) ; Saadatmand, Maryam (Supervisor) ; Eskandari, Mahnaz (Supervisor)
Abstract
Due to the increasing need of use of drugs and insufficient efficiency of conventional methods, drug delivery systems has gathered a lot of interests. There are different systems existing for controlled drug delivery, among which is implementation of hydrogel microparticles (microgels) as carriers with high potential. The most important factor in these systems is size distribution of drug-carrying microgels and a narrow size distribution leads to a controlled and suitable release. Due to unique characteristics of microfluidic systems, significant focus has been placed on them nowadays for production of microgels with suitable morphology and narrow size distribution. Therefore, in this study...
Design and Manufacture of a Scaffold with a Drug Delivery System for a Better Tissue Wound Healing Process
, M.Sc. Thesis Sharif University of Technology ; Shamloo, Amir (Supervisor) ; Aryanpour, Masoud (Supervisor)
Abstract
Articular cartilage is devoid of blood vessels, lymphatics, and nerves which gives it a very limited intrinsic healing and repair capabilities. Being under constant harsh biomechanical environment, makes maintaining the health of articular cartilage a vital principle in having healthy joints. Tissue engineering as a method for regeneration of damaged tissue have attracted a lot of attention. Articular cartilage engineered scaffolds act as a macro scale drug delivery system which in addition to having a good mechanical properties similar to that of cartilage tissue, have to provide a highly porous environment for cell migration and proliferation. The aim of this study is to fabricate a drug...
Design and Fabrication of Polymeric Drug Delivery System and Investigation of its Release Behavior
, M.Sc. Thesis Sharif University of Technology ; Vosoughi, Manoochehr (Supervisor) ; Alizadeh, Ali (Supervisor)
Abstract
In the present study we examined the fabrication of electrospun polymer drug delivery system for the production of polymeric film containing Rizatriptan drug. Fabricated films were underwent X-ray diffraction and DSC tests to ensure that the drug is not in crystalline and amorphous form. And the results revealed the fact that the drug is fully dispersed in the polymer. pH changes in the aqueous phase is too low so that it enable the polymeric film to be suitable for use in oral administration. In-vitro assay for different combination of sublingual polymeric suggested that Rizatriptan film with 3% weight by volume and 30% by weight by volume of electrospun polymer PVP is the best combination...
Designing and Manufactureing a Concentration Gradient Generator
, M.Sc. Thesis Sharif University of Technology ; kashaninezhad, navid (Supervisor)
Abstract
Nowadays, due to the growing need of the human to further improve the health of the community, research in the field of pharmacology as well as simulation of the cell culture environment is increasing. One of the most important requirements for simulating cell culture is the use of concentration gradient in culture media. The reason for this is the dependence of cellular activity on the presence of a gradient of concentration in the environment. Also, in drug investigations, in order to speed up the examination of different drugs and reduce the amount of drug that will used, different concentrations of the drug should be considered simultaneously in the microchips. Therefore, to make the...
Hydrogel Design and Development for Osteoarthritis Treatment
, M.Sc. Thesis Sharif University of Technology ; Yaghmaei, Soheyla (Supervisor) ; Mashayekhan, Shohreh (Supervisor)
Abstract
"osteoarthritis" is one of the most common joint diseases. This disease has a close relationship with factors such as aging, weight gain, genetics, mechanical pressures, and severe injuries. Although the mechanism of this disease is not fully understood, inflammation is one of the main causes of its exacerbation and progression. controlling inflammation can greatly help in controlling the disease. One of the common treatment methods for osteoarthritis is intra-articular injection of hyaluronic acid and triamcinolone as anti-inflammatory drug. Hyaluronic acid is the main component of synovial fluid, with its viscosupplementation property, prevents bones from rubbing against each other in the...
Design of Drug Nanocarriers Based on Mesoporous Silica Nanoparticles Coated with Smart Polymers
, Ph.D. Dissertation Sharif University of Technology ; Pourjavadi, Ali (Supervisor)
Abstract
Mesoporous silica nanoparticles have broad application in drud delivery systems due to their porous structure, functionalization, biocompatibility, high surface area and pore volume. Neverthless, pure mesoporous silica nanoparticles without functionality were not smart material and could not release drug in triggered and controlled manner. For this reason, using smart polymeric coating would be considered. Polymer shells also provide colloidal stability, improved blood circulation lifetime and reduced toxicity which are crucial for efficient in vivo drug delivery. Inflammatory and tumor tissue have low pH and high temperature as compared to health tissue. Therefore, using pH and...
3d Design of a Microfluidic Chip for Anticancer Drugs Screening
, M.Sc. Thesis Sharif University of Technology ; Mashayekhan, Shohreh (Supervisor) ; Saadatmand, Maryam (Supervisor)
Abstract
Nowadays, advanced and inexpensive pre-clinical methods for investigating the effects of anti-cancer drugs are expanding. One of the latest three-dimensional laboratory modeling for evaluating the effects of drugs is the use of tumor-on-chip technology, which actually models the physiological system of the body through three-dimensional scaffolds, multicellular cultures, and shaped vascular systems. In this study, three-dimensional culture of cancer cells was performed in the form of spheroids. A chip of U-shaped microstructures with and without gaps was used to trap cells and form cancer spheroids. We simulated the simultaneous effect of drug and oxygen concentration distribution inside the...
Design of Oxidative Stress Nanoparticles for Targeted drug Delivery to the Posterior Segment of the Eye and Breast Cancer
, Ph.D. Dissertation Sharif University of Technology ; Abdekhodaei, Mohammad Jafar (Supervisor) ; Baharvand, Hossein (Supervisor) ; Satarian, Leila ($item.subfieldsMap.e) ; Sadeghi, Hamid ($item.subfieldsMap.e)
Abstract
The oxidation-reduction (redox) responsive micelle system is based on a diselenide-containing triblock copolymer, poly(ε-caprolactone)-bis(diselenide-methoxy poly(ethylene glycol)/poly(ethylene glycol)-folate) [PCL-(SeSe-mPEG/PEG-FA)2]. Resulting in the development of tumor-targeted delivery for hydrophobic anticancer drugs. The diselenide bond, as redox-sensitive linkage, was designed, so it is located at the hydrophilic/hydrophobic hinge to allow complete micelles collapse and efficient drug release, in redox environments. The amphiphilic block copolymers self-assembled into micelles at concentrations above the critical micelle concentration (CMC) in an aqueous environment. Dynamic light...