Sharif Digital Repository

Being the second cause of mortality across the globe, there is now a persistent effort to establish new cancer medication and therapies. Any accomplishment in treating cancers entails the existence of accurate identification systems empowering the early diagnosis. Recent studies indicate CTCs’ potential in cancer prognosis as well as therapy monitoring. The chief shortcoming with CTCs is that they are exceedingly rare cells in their clinically relevant concentration. Here, we simulated a microfluidic construct devised for immunomagnetic separation of the particles of interest from the background cells. This separation unit is integrated with a mixer subunit. The mixer is envisioned for... 

Lab-on-a-chip (LOC) systems have been widely used in chemical and medical analyses. In this study, a novel T-shaped electroosmotic micromixer was simulated and the effects of different parameters on the mixing process were examined. These parameters include; inlet angle, number of conducting hurdles, arrangements of the hurdles, geometry of hurdles and chambers, aspect ratios of the channel cross-sectional profile, hurdle radius, and depth. It was found that the inlet angle has a direct influence on mixing index (σ). The effect of various number of hurdles (one, two, three and four hurdles) and their orientations was investigated. Simulations revealed that using two conducting hurdles is the...