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Exploring contraction–expansion inertial microfluidic-based particle separation devices integrated with curved channels
, Article AIChE Journal ; Volume 65, Issue 11 , 2019 ; 00011541 (ISSN) ; Abdorahimzadeh, S ; Nasiri, R ; Sharif University of Technology
John Wiley and Sons Inc
2019
Abstract
Separation of particles or cells has various applications in biotechnology, pharmaceutical and chemical industry. Inertial cell separation, in particular, has been gaining a great attention in the recent years since it has exhibited a label-free, high-throughput and efficient performance. In this work, first, an inertial contraction–expansion array microchannel device, capable of passively separating two particles with diameters of 4 and 10 μm, was numerically studied. Then, the validated model was combined with curved geometries in order to investigate the effect of curve features on the separation process. The overall purpose was to investigate the interaction between the two different...