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      Efficient synthesis of novel 3-substituted coumarin-3-carboxamide

      , Article Journal of the Korean Chemical Society ; Vol. 58, Issue. 2 , 20 April , 2014 , pp. 186-192 ; ISSN: 2234-8530 (Online) Sheikhhosseini, E ; Balalaie, S ; Bigdeli, M. A ; Habibi, A ; Moghaddam, H. P ; Sharif University of Technology
      Abstract
      A series of novel pseudopeptides contained coumarin skeleton were synthesized through the Ugi-four-component reaction. The 3-substituted coumarin-3-carboxamides were formed through reaction of benzaldehyde derivatives, anilines, coumarin-3- carboxylic acid and isocyanides with high yields and high bond-forming efficiency at room temperature. These novel amidated coumarins exhibit brilliant fluorescence in range of 535-547 nm in chloroform  
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