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Deling and Simulation of Human Lung
, Ph.D. Dissertation Sharif University of Technology ; Bozorgmehry Boozarjomhery, Ramin (Supervisor)
Abstract
The bronchial tree consists of two main parts: conducting airways and respiratory airways. Parametric Lindenmayer System (L-System) has been used for modeling of the structure. The conducting airways are divided into two parts: central region consisting of trachea up to segmental bronchi and bronchioles located in the bronchopulmonary segments. The boundary of these segments has been found by image processing techniques. Stochastic Parametric L-system has been used for modeling of acinar region. To find the characteristic properties of conducting airways and respiratory bronchioles, an intelligent method has been developed. The parameters of the model are either age dependent or...
Simulation, Design and Fabrication of Microfluidic Systems for the Enrichment of Cancer Stem Cells and the Pharmacological Tests
, M.Sc. Thesis Sharif University of Technology ; Saeedi, Mohammad Saeed (Supervisor) ; Kashaninejad, Navid (Co-Supervisor) ; Trung Nguyen, Nam (Co-Supervisor)
Abstract
Cancer is one of the leading causes of death worldwide, and despite all the advances in medical science, there isn't any definitive cure for it, yet. Researchers have recently considered the presence of cancer stem cells with the capability of tumorigenesis, invasion, metastasis, self-renewal, etc. as the main cause of inefficiency of cancer treatment. It means current therapies are able to kill the tumor mass, but they are not successful in confront of cancer stem cells and this causes the disease to recur a while after the apparent recovery. To study these specific cells, in this project, first the population of cancer stem-like cells was increased in the cancer cell mass, in other words,...
Design of Scaffolds with Multi-scale Engineered Microchannels
, M.Sc. Thesis Sharif University of Technology ; Saadatmand, Maryam (Supervisor)
Abstract
Building complex and functional tissues and organs is very challenging. One of the challenges is building an efficient network of blood vessels that can be used to facilitate the transport of nutrients and oxygen to the host. In addition to using channels for oxygen supply, another solution is to use oxygen-carrying materials. In this study, in addition to designing and simulating scaffolds with multi-scale microchannels, calcium peroxide was used to release oxygen and eliminate hypoxia in the scaffold. Here alginate is used as the main material for scaffolding. In an attempt to build a scaffold using a bio-printer, pluronic acid was also used as a sacrificial material to create canals....
3D Bioprinting of oxygenated cell-laden gelatin methacryloyl constructs
, Article Advanced Healthcare Materials ; Volume 9, Issue 15 , 2020 ; Darabi, M. A ; Nasiri, R ; Sangabathuni, S ; Ertas, Y. N ; Alem, H ; Hosseini, V ; Shamloo, A ; Nasr, A. S ; Ahadian, S ; Dokmeci, M. R ; Khademhosseini, A ; Ashammakhi, N ; Sharif University of Technology
Wiley-VCH Verlag
2020
Abstract
Cell survival during the early stages of transplantation and before new blood vessels formation is a major challenge in translational applications of 3D bioprinted tissues. Supplementing oxygen (O2) to transplanted cells via an O2 generating source such as calcium peroxide (CPO) is an attractive approach to ensure cell viability. Calcium peroxide also produces calcium hydroxide that reduces the viscosity of bioinks, which is a limiting factor for bioprinting. Therefore, adapting this solution into 3D bioprinting is of significant importance. In this study, a gelatin methacryloyl (GelMA) bioink that is optimized in terms of pH and viscosity is developed. The improved rheological properties...
Unraveling cancer metastatic cascade using microfluidics-based technologies
, Article Biophysical Reviews ; Volume 14, Issue 2 , 2022 , Pages 517-543 ; 18672450 (ISSN) ; Kermanshah, L ; Abouali, H ; Hashemi, H. M ; Yari, A ; Khorasheh, F ; Alemzadeh, I ; Vossoughi, M ; Sharif University of Technology
Springer Science and Business Media Deutschland GmbH
2022
Abstract
Cancer has long been a leading cause of death. The primary tumor, however, is not the main cause of death in more than 90% of cases. It is the complex process of metastasis that makes cancer deadly. The invasion metastasis cascade is the multi-step biological process of cancer cell dissemination to distant organ sites and adaptation to the new microenvironment site. Unraveling the metastasis process can provide great insight into cancer death prevention or even treatment. Microfluidics is a promising platform, that provides a wide range of applications in metastasis-related investigations. Cell culture microfluidic technologies for in vitro modeling of cancer tissues with fluid flow and the...
Hybrid multiscale modeling and prediction of cancer cell behavior
, Article PLoS ONE ; Volume 12, Issue 8 , 2017 ; 19326203 (ISSN) ; Habibi, J ; Sharif University of Technology
Public Library of Science
2017
Abstract
Background: Understanding cancer development crossing several spatial-temporal scales is of great practical significance to better understand and treat cancers. It is difficult to tackle this challenge with pure biological means. Moreover, hybrid modeling techniques have been proposed that combine the advantages of the continuum and the discrete methods to model multiscale problems. Methods: In light of these problems, we have proposed a new hybrid vascular model to facilitate the multiscale modeling and simulation of cancer development with respect to the agent-based, cellular automata and machine learning methods. The purpose of this simulation is to create a dataset that can be used for...
Review of oxygenation with nanobubbles: possible treatment for hypoxic covid-19 patients
, Article ACS Applied Nano Materials ; Volume 4, Issue 11 , 2021 , Pages 11386-11412 ; 25740970 (ISSN) ; Akhavan, O ; Hamblin, M. R ; Varma, R. S ; Sharif University of Technology
American Chemical Society
2021
Abstract
The coronavirus disease (COVID-19) pandemic, which has spread around the world, caused the death of many affected patients, partly because of the lack of oxygen arising from impaired respiration or blood circulation. Thus, maintaining an appropriate level of oxygen in the patients' blood by devising alternatives to ventilator systems is a top priority goal for clinicians. The present review highlights the ever-increasing application of nanobubbles (NBs), miniature gaseous vesicles, for the oxygenation of hypoxic patients. Oxygen-containing NBs can exert a range of beneficial physiologic and pharmacologic effects that include tissue oxygenation, as well as tissue repair mechanisms,...
Review of Oxygenation with Nanobubbles: Possible Treatment for Hypoxic COVID-19 Patients
, Article ACS Applied Nano Materials ; Volume 4, Issue 11 , 2021 , Pages 11386-11412 ; 25740970 (ISSN) ; Akhavan, O ; Hamblin, M. R ; Varma, R. S ; Sharif University of Technology
American Chemical Society
2021
Abstract
The coronavirus disease (COVID-19) pandemic, which has spread around the world, caused the death of many affected patients, partly because of the lack of oxygen arising from impaired respiration or blood circulation. Thus, maintaining an appropriate level of oxygen in the patients' blood by devising alternatives to ventilator systems is a top priority goal for clinicians. The present review highlights the ever-increasing application of nanobubbles (NBs), miniature gaseous vesicles, for the oxygenation of hypoxic patients. Oxygen-containing NBs can exert a range of beneficial physiologic and pharmacologic effects that include tissue oxygenation, as well as tissue repair mechanisms,...