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    Higher prevalence of asymptomatic or mild COVID-19 in children, claims and clues

    , Article Journal of Medical Virology ; Volume 92, Issue 11 , May , 2020 , Pages 2257-2259 Miri, S. M ; Noorbakhsh, F ; Mohebbi, S. R ; Ghaemi, A
    John Wiley and Sons Inc  2020

    Gut-on-a-chip: Current progress and future opportunities

    , Article Biomaterials ; Volume 255 , 2020 Ashammakhi, N ; Nasiri, R ; Barros, N. R. D ; Tebon, P ; Thakor, J ; Goudie, M ; Shamloo, A ; Martin, M. G ; Khademhosseni, A ; Sharif University of Technology
    Elsevier Ltd  2020
    Abstract
    Organ-on-a-chip technology tries to mimic the complexity of native tissues in vitro. Important progress has recently been made in using this technology to study the gut with and without microbiota. These in vitro models can serve as an alternative to animal models for studying physiology, pathology, and pharmacology. While these models have greater physiological relevance than two-dimensional (2D) cell systems in vitro, endocrine and immunological functions in gut-on-a-chip models are still poorly represented. Furthermore, the construction of complex models, in which different cell types and structures interact, remains a challenge. Generally, gut-on-a-chip models have the potential to... 

    CRISPR-Cas, a robust gene-editing technology in the era of modern cancer immunotherapy

    , Article Cancer Cell International ; Volume 20, Issue 1 , September , 2020 Miri, S. M ; Tafsiri, E ; Cho, W. C. S ; Ghaemi, A ; Sharif University of Technology
    BioMed Central Ltd  2020
    Abstract
    Cancer immunotherapy has been emerged as a promising strategy for treatment of a broad spectrum of malignancies ranging from hematological to solid tumors. One of the principal approaches of cancer immunotherapy is transfer of natural or engineered tumor-specific T-cells into patients, a so called "adoptive cell transfer", or ACT, process. Construction of allogeneic T-cells is dependent on the employment of a gene-editing tool to modify donor-extracted T-cells and prepare them to specifically act against tumor cells with enhanced function and durability and least side-effects. In this context, CRISPR technology can be used to produce universal T-cells, equipped with recombinant T cell...