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کلیدواژه های تکراریCurcumin loading potentiates the neuroprotective efficacy of Fe3O4 magnetic nanoparticles in cerebellum cells of schizophrenic rats
, Article Biomedicine and Pharmacotherapy ; Volume 108 , 2018 , Pages 1244-1252 ; 07533322 (ISSN) ; Ashrafi Hafez, A ; Abdorahim, M ; Abdollahifar, M. A ; Shabani, R ; Peirovi, H ; Simchi, A ; Ashtari, K ; Sharif University of Technology
Abstract
Background: The aim of this study was to investigate the neurotoxic effects of Fe3O4 magnetic- CurNPs on isolated schizophrenia mitochondria of rats as an in vivo model. Methods: We designed CMN loaded superparamagnetic iron oxide nanoparticles (SPIONs) (Fe3O4 magnetic- CurNPs) to achieve an enhanced therapeutic effect. The physicochemical properties of Fe3O4 magnetic- CurNPs were characterized using X-ray diffraction (XRD), and dynamic laser light scattering (DLS) and zeta potential. Further, to prove Fe3O4 magnetic- CurNPs results in superior therapeutic effects, and also, the mitochondrial membrane potential collapse, mitochondrial complex II activity, reactive oxygen species generation,...
ZnFe2O4 nanoparticles as radiosensitizers in radiotherapy of human prostate cancer cells
, Article Materials Science and Engineering C ; Volume 46 , January , 2015 , Pages 394-399 ; 09284931 (ISSN) ; Akhavan, O ; Khoei, S ; Shokri, A. A ; Hajikarimi, Z ; Khansari, N ; Sharif University of Technology
Elsevier Ltd
2015
Abstract
Nanoparticles of high-Z elements exhibit stronger photoelectric effects than soft tissues under gamma irradiation. Hence, they can be used as effective radiosensitizers for increasing the efficiency of current radiotherapy. In this work, superparamagnetic zinc ferrite spinel (ZnFe2O4) nanoparticles were synthesized by a hydrothermal reaction method and used as radiosensitizers in cancer therapy. The magnetic nanoparticles showed fast separation from solutions (e.g., ~ 1 min for 2 mg mL- 1 of the nanoparticles in ethanol) by applying an external magnetic field (~ 1 T). The ZnFe2O4 nanoparticles were applied in an in vitro radiotherapy of lymph node carcinoma of prostate cells (as high...
Wolfram-like syndrome with bicuspid aortic valve due to a homozygous missense variant in CDK13
, Article Journal of Human Genetics ; Volume 66, Issue 10 , 2021 , Pages 1009-1018 ; 14345161 (ISSN) ; Raza, S. I ; Anwar, M. Z ; Bharadwaj, T ; Liaqat, K ; Khokhar, M. A. S ; Everard, J. L ; Nasir, A ; Nickerson, D. A ; Bamshad, M. J ; Ansar, M ; Schrauwen, I ; Ahmad, W ; Leal, S. M ; University of Washington Center for Mendelian Genomics ; Sharif University of Technology
Springer Nature
2021
Abstract
Background: Wolfram syndrome (WFS) is characterized by deafness, diabetes mellitus, and diabetes insipidus along with optic atrophy. WFS has an autosomal recessive mode of inheritance and is due to variants in WFS1 and CISD2. Methods: We evaluated the underlying molecular etiology of three affected members of a consanguineous family with hearing impairment, bicuspid aortic valve, diabetes mellitus and insipidus, clinodactyly, and gastrointestinal tract abnormalities via exome sequencing approach. We correlated clinical and imaging data with the genetic findings and their associated phenotypes. Results: We identified a homozygous missense variant p.(Asn1097Lys) in CDK13, a gene previously...
Whole-genome analysis of de novo somatic point mutations reveals novel mutational biomarkers in pancreatic cancer
, Article Cancers ; Volume 13, Issue 17 , 2021 ; 20726694 (ISSN) ; Mohseni, A ; Dashti, H ; Beheshti, A ; Dehzangi, A ; Rabiee, H. R ; Alinejad Rokny, H ; Sharif University of Technology
MDPI
2021
Abstract
It is now known that at least 10% of samples with pancreatic cancers (PC) contain a causative mutation in the known susceptibility genes, suggesting the importance of identifying cancer-associated genes that carry the causative mutations in high-risk individuals for early detection of PC. In this study, we develop a statistical pipeline using a new concept, called gene-motif, that utilizes both mutated genes and mutational processes to identify 4211 3-nucleotide PC-associated gene-motifs within 203 significantly mutated genes in PC. Using these gene-motifs as distinguishable features for pancreatic cancer subtyping results in identifying five PC subtypes with distinguishable phenotypes and...
Visual acuity classification using single trial visual evoked potentials
, Article Proceedings of the 31st Annual International Conference of the IEEE Engineering in Medicine and Biology Society: Engineering the Future of Biomedicine, EMBC 2009 ; 2009 , Pages 982-985 ; 1557170X (ISSN) ; Shamsollahi, M. B ; Abootalebi, V ; Sharif University of Technology
Abstract
Several researches have been done to identify visual system characteristics. Some of them are based on the processing of the brain signal recordings. Visual evoked potentials (VEPs) are electrical signals which are produced in response to the visual stimuli and recorded by means of electrodes placed on the head. These signals are usually characterized by the amplitude and latency of their peaks. Different types of visual stimuli and visual system characteristics can affect the shape and hence the characteristics of VEPs. In this paper, proper visual stimuli were used and VEPs were recorded in order to classify visual acuity. To achieve this goal, visual evoked potentials were recorded and...
Validation of the revised stressful life event questionnaire using a hybrid model of genetic algorithm and artificial neural networks
, Article Computational and Mathematical Methods in Medicine ; Volume 2013 , 2013 ; 1748670X (ISSN) ; Roohafza, H ; Sadeghi, M ; Andalib, E ; Shavandi, H ; Sarrafzadegan, N ; Sharif University of Technology
2013
Abstract
Objectives. Stressors have a serious role in precipitating mental and somatic disorders and are an interesting subject for many clinical and community-based studies. Hence, the proper and accurate measurement of them is very important. We revised the stressful life event (SLE) questionnaire by adding weights to the events in order to measure and determine a cut point. Methods. A total of 4569 adults aged between 18 and 85 years completed the SLE questionnaire and the general health questionnaire-12 (GHQ-12). A hybrid model of genetic algorithm (GA) and artificial neural networks (ANNs) was applied to extract the relation between the stressful life events (evaluated by a 6-point Likert scale)...
Using robotic mechanical perturbations for enhanced balance assessment
, Article Medical Engineering and Physics ; Volume 83 , 2020 , Pages 7-14 ; Behjat, A ; Torabi, A ; Behzadipour, S ; Sharif University of Technology
Elsevier Ltd
2020
Abstract
Balance impairment is critical for many patient groups such as those with neural and musculoskeletal disorders and also the elderly. Accurate and objective assessment of balance performance has led to the development of several indices based on the measurement of the center of pressure. In this study, a robotic device was designed and fabricated to provide controlled and repeatable mechanical perturbations to the standing platform of the user. The device uses servo-controlled actuators and two parallel mechanisms to provide independent rotations in mediolateral and anterior-posterior directions. The device also provides visual feedback of the center of pressure position to the user....
Urine and serum NMR-based metabolomics in pre-procedural prediction of contrast-induced nephropathy
, Article Internal and Emergency Medicine ; Volume 15, Issue 1 , 2020 , Pages 95-103 ; Chashmniam, S ; Khoormizi, S. M. H ; Salehi, L ; Jamalian, S. A ; Nafar, M ; Kalantari, S ; Sharif University of Technology
Springer
2020
Abstract
Contrast induced nephropathy (CIN) has been reported to be the third foremost cause of acute renal failure. Metabolomics is a robust technique that has been used to identify potential biomarkers for the prediction of renal damage. We aim to analyze the serum and urine metabolites changes, before and after using contrast for coronary angiography, to determine if metabolomics can predict early development of CIN. 66 patients undergoing elective coronary angiography were eligible for enrollment. Urine and serum samples were collected prior to administration of CM and 72 h post procedure and analyzed by nuclear magnetic resonance. The significant differential metabolites between patients who...
Type V collagen in scar tissue regulates the size of scar after heart injury
, Article Cell ; Volume 182, Issue 3 , 2020 , Pages 545-562.e23 ; McCourt, J ; Ma, F ; Ren, S ; Li, S ; Kim, T. H ; Kurmangaliyev, Y. Z ; Nasiri, R ; Ahadian, S ; Nguyen, T ; Tan, X. H. M ; Zhou, Y ; Wu, R ; Rodriguez, A ; Cohn, W ; Wang, Y ; Whitelegge, J ; Ryazantsev, S ; Khademhosseini, A ; Teitell, M. A ; Chiou, P. Y ; Birk, D. E ; Rowat, A. C ; Crosbie, R. H ; Pellegrini, M ; Seldin, M ; Lusis, A. J ; Deb, A ; Sharif University of Technology
Cell Press
2020
Abstract
Scar tissue size following myocardial infarction is an independent predictor of cardiovascular outcomes, yet little is known about factors regulating scar size. We demonstrate that collagen V, a minor constituent of heart scars, regulates the size of heart scars after ischemic injury. Depletion of collagen V led to a paradoxical increase in post-infarction scar size with worsening of heart function. A systems genetics approach across 100 in-bred strains of mice demonstrated that collagen V is a critical driver of postinjury heart function. We show that collagen V deficiency alters the mechanical properties of scar tissue, and altered reciprocal feedback between matrix and cells induces...
Trunk musculoskeletal response in maximum voluntary exertions: a combined measurement-modeling investigation
, Article Journal of Biomechanics ; Volume 70 , March , 2018 , Pages 124-133 ; 00219290 (ISSN) ; El Ouaaid, Z ; Shirazi Adl, A ; Plamondon, A ; Arjmand, N ; Sharif University of Technology
Elsevier Ltd
2018
Abstract
Maximum voluntary exertion (MVE) tasks quantify trunk strength and maximal muscle electromyography (EMG) activities with both clinical and biomechanical implications. The aims here are to evaluate the performance of an existing trunk musculoskeletal model, estimate maximum muscle stresses and spinal forces, and explore likely differences between males and females in maximum voluntary exertions. We, therefore, measured trunk strength and EMG activities of 19 healthy right-handed subjects (9 females and 10 males) in flexion, extension, lateral and axial directions. MVEs for all subjects were then simulated in a subject-specific trunk musculoskeletal model, and estimated muscle activities were...
Trunk muscles strength and endurance in chronic low back pain patients with and without clinical instability
, Article Journal of Back and Musculoskeletal Rehabilitation ; Volume 25, Issue 2 , 2012 , Pages 123-129 ; 10538127 (ISSN) ; Maroufi, N ; Ebrahimi, I ; Farahmand, F ; Parnianpour, M ; Sharif University of Technology
2012
Abstract
Objectives: Previous research has shown inconsistent findings regarding muscle endurance in chronic low back pain (CLBP). Questions also remain about muscle endurance in patients with clinical instability. The aim of this study was to investigate trunk muscles strength and endurance in CLBP patients with and without clinical instability. Methods: 32 CLBP patients (15 with and 17 without clinical instability) and 39 matched healthy subjects participated in this study. The standing extension test was performed to assess the strength and endurance of the lumbar extensors while recording their electromyographic activity. The patients' disability was evaluated using the Oswestry and Roland-Morris...
Trunk muscle fatigue and its implications in EMG-assisted biomechanical modeling
, Article International Journal of Industrial Ergonomics ; Volume 43, Issue 5 , 2013 , Pages 425-429 ; 01698141 (ISSN) ; Mirka, G.A ; Sharif University of Technology
2013
Abstract
Muscle fatigue affects the underlying EMG-force relationship on which EMG-assisted biomechanical models rely. The aim of this study was to evaluate the impact of short duration muscle fatigue on the muscle gain value. Participants performed controlled, isometric trunk extension exertions at 10, 20, and 30 degrees of trunk flexion and controlled isokinetic trunk extension exertions at 5 and 15°/sec on five separate days. Fatigue of the lumbar extensors was generated by moderate-intensity, trunk extension exertions. Participants performed controlled test contractions at defined intervals throughout the fatiguing bout and the EMG activities of trunk muscles were collected. These EMG data were...
Trunk dynamic stability assessment for individuals with and without nonspecific low back pain during repetitive movement
, Article Human Factors ; Volume 64, Issue 2 , 2022 , Pages 291-304 ; 00187208 (ISSN) ; Mokhtarinia, H. R ; Sanjari, M. A ; Kahrizi, S ; Philip, G. C ; Parnianpour, M ; Khalaf, K ; Sharif University of Technology
SAGE Publications Inc
2022
Abstract
Objective: This study aimed to employ nonlinear dynamic approaches to assess trunk dynamic stability with speed, symmetry, and load during repetitive flexion-extension (FE) movements for individuals with and without nonspecific low back pain (NSLBP). Background: Repetitive trunk FE movement is a typical work-related LBP risk factor contingent on speed, symmetry, and load. Improper settings/adjustments of these control parameters could undermine the dynamic stability of the trunk, hence leading to low back injuries. The underlying stability mechanisms and associated control impairments during such dynamic movements remain elusive. Method: Thirty-eight male volunteers (19 healthy, 19 NSLBP)...
Trunk coordination in healthy and chronic nonspecific low back pain subjects during repetitive flexion-extension tasks: Effects of movement asymmetry, velocity and load
, Article Human Movement Science ; Volume 45 , 2016 , Pages 182-192 ; 01679457 (ISSN) ; Sanjari, M. A ; Chehrehrazi, M ; Kahrizi, S ; Parnianpour, M ; Sharif University of Technology
Elsevier
Abstract
Multiple joint interactions are critical to produce stable coordinated movements and can be influenced by low back pain and task conditions. Inter-segmental coordination pattern and variability were assessed in subjects with and without chronic nonspecific low back pain (CNSLBP). Kinematic data were collected from 22 CNSLBP and 22 healthy volunteers during repeated trunk flexion-extension in various conditions of symmetry, velocity, and loading; each at two levels. Sagittal plane angular data were time normalized and used to calculate continuous relative phase for each data point. Mean absolute relative phase (MARP) and deviation phase (DP) were derived to quantify lumbar-pelvis and...
Trunk, pelvis, and knee kinematics during running in females with and without patellofemoral pain
, Article Gait and Posture ; Volume 89 , 2021 , Pages 80-85 ; 09666362 (ISSN) ; Ebrahimi, S ; Rezaie, M ; Shafiee, E ; Shokouhyan, S. M ; Motealleh, A ; Parnianpour, M ; Sharif University of Technology
Elsevier B.V
2021
Abstract
Background: Females are two times more likely to develop patellofemoral pain (PFP) than males. Abnormal trunk and pelvis kinematics are thought to contribute to the pathomechanics of this condition. However, there is a scarcity of evidence investigating proximal segments kinematics in females with PFP. Research question: The purpose of this study was to investigate whether females with PFP demonstrate altered trunk, pelvis, and knee joint kinematics compared with healthy controls during running. Methods: Thirty-four females (17 PFP, 17 controls) underwent a 3-dimensional motion analysis during treadmill running at preferred and fixed speeds, each trial for 30 s. Variables of interest...
Trapezius muscle activity in using ordinary and ergonomically designed dentistry chairs
, Article International Journal of Occupational and Environmental Medicine ; Volume 3, Issue 2 , Apr , 2012 , Pages 76-83 ; 20086520 (ISSN) ; Sanjari, M. A ; Amirfazli, A ; Narimani, R ; Parnianpour, M ; Sharif University of Technology
Abstract
Background: Most dentists complain of musculoskeletal disorders which can be caused by prolonged static posture lack of suitable rest and other physical and psychological problems. Objective: We evaluated a chair with a new ergonomic design which incorporated forward leaning chest and arm supports. Methods: The chair was evaluated in the laboratory during task simulation and EMG analysis on 12 students and subjectively assessed by 30 professional dentists using an 18-item questionnaire. EMG activity of right and left trapezius muscles for 12 male students with no musculoskeletal disorders was measured while simulating common tasks like working on the teeth of the lower jaw. Results:...
Translation and validation study of the Persian version of the Arthritis Impact Measurement Scales 2 (AIMS2) in patients with osteoarthritis of the knee
, Article BMC Musculoskeletal Disorders ; Volume 10, Issue 1 , 2009 ; 14712474 (ISSN) ; Parnianpour, M ; Askary Ashtiani, A. R ; Hadian, M. R ; Rostamian, A ; Montazeri, A ; Sharif University of Technology
2009
Abstract
Background. The Arthritis Impact Measurement Scales 2 (AIMS2) has not been translated and validated for Persian-speaking patients with osteoarthritis of the knee. This was to provide a validated instrument to measure functional disability and health-related quality of life in patients with osteoarthritis of the knee in Iran. The aim of this study was to culturally adapt and validate the AIMS2 for Persian-speaking patients with osteoarthritis of the knee in Iran. Methods. A consecutive sample of patients with knee osteoarthritis were asked to complete the AIMS2, the Short Form Health Survey (SF-36) and four visual analog scales for pain, joint stiffness, patient's and physician's global...
Translation and validation study of the Iranian versions of the neck disability index and the neck pain and disability scale
, Article Spine ; Volume 32, Issue 26 , 2007 , Pages E825-E831 ; 03622436 (ISSN) ; Parnianpour, M ; Montazeri, A ; Mehdian, H ; Karimi, A ; Abedi, M ; Askary Ashtiani, A ; Mobini, B ; Hadian, M. R ; Sharif University of Technology
2007
Abstract
STUDY DESIGN. Cultural translation and psychometric testing. OBJECTIVE. To translate and validate the Iranian versions of the Neck Disability Index (NDI-IR) and the Neck Pain and Disability Scale (NPDS-IR). SUMMARY OF BACKGROUND DATA. The widely used the NDI and the NPDS scales have not been translated and validated for Persian-speaking patients with neck pain. This was to provide a validated instrument to measure functional status in patients with neck pain in Iran. METHODS. The translation and cultural adaptation of the original questionnaires were carried out in accordance with the published guidelines. One hundred and eighty-five patients with neck pain were participated in the study....
Translation and validation of the Persian version of the Arthritis Impact Measurement Scales 2-Short Form (AIMS2-SF) in patients with rheumatoid arthritis
, Article Clinical Rheumatology ; Volume 28, Issue 5 , 2009 , Pages 521-527 ; 07703198 (ISSN) ; Mousavi, S. J ; Parnianpour, M ; Montazeri, A ; Sharif University of Technology
2009
Abstract
Cultural adaptation and validation of the Persian version of the Arthritis Measurement Scales 2-Short Form (AIMS2-SF). The translation and cultural adaptation of the original questionnaire was carried out in accordance with published guidelines. Three hundred and fifty consecutive Persian-speaking patients with rheumatoid arthritis (RA) were asked to complete the AIMS2-SF, the Short Form Health Survey (SF-36), and four visual analog scales (VAS) for pain, joint stiffness, and patient's and physician's global assessment to test convergent validity. In addition, 90 randomly selected patients were asked to complete the questionnaire 48 h later for the second time. Moderate to high correlation...
Trajectory of human movement during sit to stand: A new modeling approach based on movement decomposition and multi-phase cost function
, Article Experimental Brain Research ; Volume 229, Issue 2 , 2013 , Pages 221-234 ; 00144819 (ISSN) ; Andani, M. E ; Bahrami, F ; Parnianpour, M ; Sharif University of Technology
2013
Abstract
The purpose of this work is to develop a computational model to describe the task of sit to stand (STS). STS is an important movement skill which is frequently performed in human daily activities, but has rarely been studied from the perspective of optimization principles. In this study, we compared the recorded trajectories of STS with the trajectories generated by several conventional optimization-based models (i.e., minimum torque, minimum torque change and kinetic energy cost models) and also with the trajectories produced by a novel multi-phase cost model (MPCM). In the MPCM, we suggested that any complex task, such as STS, is decomposable into successive motion phases, so that each...