Sharif Digital Repository

Epilepsy is the most common neurological disorder that is known with uncontrolled seizure. Around 30% of patients with epilepsy resist to all forms of medical treatments and therefore, the removal of epileptic brain tissue is the only solution to get these patients free from chronical seizures. The precise detection of an epileptic zone is key to its treatment. In this paper, we propose a method of epilepsy detection using brain magnetic field. The possibility of superparamagnetic nanoparticle (SPMN) as sensors for the detection of the epileptic area inside the brain is investigated. The aggregation of nanoparticles in the weak magnetic field of epileptic brain is modeled using potential... 

Nanocages (NCs) have emerged as a new class of drug-carriers, with a wide range of possibilities in multi-modality medical treatments and theranostics. Nanocages can overcome such limitations as high toxicity caused by anti-cancer chemotherapy or by the nanocarrier itself, due to their unique characteristics. These properties consist of: (1) a high loading-capacity (spacious interior); (2) a porous structure (analogous to openings between the bars of the cage); (3) enabling smart release (a key to unlock the cage); and (4) a low likelihood of unfavorable immune responses (the outside of the cage is safe). In this review, we cover different classes of NC structures such as virus-like... 

A magnetic actuation system is a promising tool for untethered manipulation at the microscale that medical treatment can benefit from. This paper proposes a new magnetic actuation system that comprises of two coaxial coils on a rotary table. A fixed workspace is placed between coils. The proposed system is able to generate magnetic force with desired direction and magnitude in a plane. The conducted simulation and experiment confirm the capability of the proposed system to control the position of the microrobot. © 2019 IEEE  

Organ-on-a-chip technology tries to mimic the complexity of native tissues in vitro. Important progress has recently been made in using this technology to study the gut with and without microbiota. These in vitro models can serve as an alternative to animal models for studying physiology, pathology, and pharmacology. While these models have greater physiological relevance than two-dimensional (2D) cell systems in vitro, endocrine and immunological functions in gut-on-a-chip models are still poorly represented. Furthermore, the construction of complex models, in which different cell types and structures interact, remains a challenge. Generally, gut-on-a-chip models have the potential to... 

This paper describes a nursing robot system currently under development at the Center of Excellence in Design, Robotics and Automation. Our goal was to design and fabricate of a robot specifically for paraplegic patients and the design procedure led to a plan which can be employed in any hospital environment. Through the design procedure, the team members conducted a survey on the robot client's needs and disabilities which provided a unique view on mechanical design features, in addition to, performing dynamical analysis on the designed mechanisms. Dynamical Simulation of mechanisms helped us to find the best design and solutions as well as optimization of parts has resulted in a matchless...