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A novel niosome formulation for encapsulation of anthocyanins and modelling intestinal transport
, Article Food Chemistry ; Volume 293 , 2019 , Pages 57-65 ; 03088146 (ISSN) ; Akay, S ; Sharifi, F ; Sevimli Gur, C ; Ongen, G ; Yesil Celiktas, O ; Sharif University of Technology
Elsevier Ltd
2019
Abstract
The bioavailability of drugs can be improved by regulating the structural properties, particularly lipoid systems, such as niosomes, can increase cellular uptake. Herein, we optimized double emulsion and niosomal formulations for encapsulating anthocyanin-rich black carrot extract. Nanoparticles obtained by selected formulation were characterized in terms of morphology, particle size, drug encapsulation efficiency, in vitro release and cytotoxicity. The optimum conditions for niosomal formulation were elicited as 30 mg of cholesterol, 150 mg of Tween 20 and feeding time of 1 min at a stirring rate of 900 rpm yielding the lowest average particle size of 130 nm. In vitro release data showed...
Amine functionalized TiO2 coated on carbon nanotube as a nanomaterial for direct electrochemistry of glucose oxidase and glucose biosensing
, Article Journal of Molecular Catalysis B: Enzymatic ; Volume 68, Issue 2 , 2011 , Pages 206-210 ; 13811177 (ISSN) ; Rafiee Pour, H. A ; Ghourchian, H ; Gholami, M. R ; Sharif University of Technology
Abstract
A nano-composite material consisting of amine functionalized TiO 2-coated carbon nanotubes was prepared and used for glucose oxidase (GOx) absorption. The GOx bearing nanomaterial was fixed on a glassy carbon electrode to construct a novel biosensor for glucose determination. The direct electrochemistry of immobilized GOx and its electron transfer parameters at the modified glassy carbon electrode were reported. The apparent heterogeneous electron transfer rate constant (ks) of GOx was estimated to be 3.5 s-1, which is higher than those reported previously. Amperometric detection of glucose resulted in a rapid (3 s) and stable response in the linear concentration range from 1.8 to 266 μM....