Search for: micromixer
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    Numerical Simulation and Analysis of Active Electro-Kinetic Micro-Mixer

    , M.Sc. Thesis Sharif University of Technology Maleki Bagherabadi, Kamyar (Author) ; Saeedi, Mohammad Saeed (Supervisor) ; Sani, Mahdi (Supervisor)
    The “Lab-on-a-Chip” is a micro-scale device which uses fluids as working medium and can handle number of functions such as sample preparation and transfer, separation, bio-sensing and detection. One of the important parts of these devices is micro-mixer, that should blend two fluid species in a short time with desirable mixing quality. Micro-mixers are classified as passive and active. By considering the micro-scale of mixers, turbulence phenomena cannot occur due to dominance of viscous forces, therefore the mixing only depends on molecular diffusion. This thesis consists of two main parts, in the first part algebraic multigrid has been studied and implemented in Rayan (in-house CFD code).... 

    Numerical Simulation and Characterization of a Micro-mixer with Moving Walls

    , M.Sc. Thesis Sharif University of Technology Omidvar, Ahmad Reza (Author) ; Saeedi , Mohammad Saeed (Supervisor) ; Sani, Mahdi (Supervisor)
    Recent advances in micro-technology are finding important applications especially in chemical and biological processes. In these applications, mixing has a profound importance. Due to the inherent low Reynold’s number flow in micro systems, diffusion mixing is the dominant mixing mechanism at these scales. This is in contrary to the high Reynold’s number ordinary applications where turbulent mixing plays the major role. There are two major classes of micro-mixers: passive and active. Passive micro-mixers rely on geometric features to enhance mixing. Active micro-mixers on the other hand, use external excitation to promote and control the rate of mixing. In this work, using numerical tools,... 

    Computational Simulation of Micromixing, Using LBM

    , M.Sc. Thesis Sharif University of Technology Hosseini-zade, Mohammad (Author) ; Taeibi-Rahni, Mohammad (Supervisor)
    Nowadays, microfluidic flow appears in many applications, such as medical, biological, and chemical industries. Where as, micromixing, which deals with mixing of microfluidic flow in micro channels, appears to be an important issue to many researchers. In such systems, molecular diffusion plays an important role. On the other hand, lattice Boltzmann method is a relatively new simulation technique for complex fluid systems and has become interesting to many researchers in computational physics. In this study, computational simulation of such mixing process, using LBM is the main objective. Different obstacle layouts inside a microchannel have been investigated. Chaotic advection and jet... 

    Design and Fabrication of Microfluidic System for Cell Lysis and DNA Purification

    , M.Sc. Thesis Sharif University of Technology Jalilvand, Elahe (Author) ; Shamloo, Amir (Supervisor) ; Hosseini, Vahid (Supervisor)
    Nowadays, intracellular studies have been widely developed in biological applications. Intracellular analysis requires direct experiments on cells such as cell separation, purification, lysis and DNA extraction. The process of cell lysis and the resulting DNA purification is a crucial step in diagnostic processes. Since, the basis of many genetic studies is the information existed in double-stranded DNA structures.In this project, a microfluidic system is presented which performs integrated chemical cell lysis and DNA extraction. The cell used in this study is L-929. In order to increase cell lysis, the serpentine micromixer in combination with internal and external barriers at the beginning... 

    Investigation of the Geometry Effect on Electrokinetic Instability in Microflows

    , M.Sc. Thesis Sharif University of Technology Mohammadzadeh, Alireza (Author) ; Saidi, Mohammad Hassan (Supervisor)
    Lab-on-a-chip devices have gained a lot of attention in chemical and biomedical analyses during the past two decades. These devices employ microfluidics basics and fundamentals to combine multifold laboratory processes in one single portable chip. The electric field has been often used in most microfluidics applications for the ease of sample control as well as become easily integrated to other chip components. Instabilities in microflows would occur when two fluids of different electric properties are exposed to an adequately strong electric field. Studying these electrokinetic instabilities is not only important for the fundamental studies but also for practical applications in micromixers... 

    Rheology Effects on Reaction-diffusion Mechanisms in a Y-shaped Micro Fluidic Mixer

    , M.Sc. Thesis Sharif University of Technology Hellisaz, Hamed (Author) ; Saeedi, Mohammad Hassan (Supervisor) ; Kazemzadeh Hannani, Siamak ($item.subfieldsMap.e)
    Numerous applications of Lab on a Chips (LOCs) in chemical/biochemical analyses as well as the emergence of advanced methods for their manufacture attracts many researchers’ attention to these micro instruments. Low sample volume consumption and their high controllability are accounted as the main advantage of LOC systems. Micromixers are among the main components of any LOC in which mixing and/or reaction among two components occur. Micromixers have many potential applications in biological and medical sciences, and so they are repeatedly charged by biofluids. Due to sensibility of biofluids, to avoid disintegration, applying electroosmotic flow instead of pressure-induced flow has priority... 

    Ionic Size and Rheology Effects on the Mixing Process of Electroosmotic Flows

    , M.Sc. Thesis Sharif University of Technology Ahmadian Yazdi, Alireza (Author) ; Saeedi, Mohammad Hassan (Supervisor) ; Mozaffari, Ali Asghar (Supervisor)
    In recent years, there have been huge advancements in fabrication of micron-sized devices such that they enabled engineers to create a wide range of miniaturized systems, each of which is utilized in mechanical, electrical, and thermal applications. Micromixers are one of these devices with the role of mixing various micro flows. These devices are broadly used for chemical, biological, and biomedical assays. Among variety of micromixers, one that employs electrokinetic transport phenomenon is of great popularity. For instance, mixing under electroosmotic flow enables accurate process control and eliminates the need for moving components inside micromixer. The very complex nature of electric... 

    Numerical and Analytical Study of Mixing in Y-shaped Micromixers: Electroosmotic and Poiseuille Flow of PTT Fluids

    , M.Sc. Thesis Sharif University of Technology Reshadi, Milad (Author) ; Saeedi, Mohammad Hassan (Supervisor) ; Mozaffari, Ali Asghar (Supervisor)
    Dissemination of an analyte under the laminar flows plays a major role in measuring and assessment of biological fluids such as sample preparation in the context of microfluidic systems. Due to the development of manufacturing technology in the Lab-on-a-chip devices, the production of rectangular microchannels with finite aspect ratios and micron and submicron sizes has been provided by which the effect of electrokinetic phenomena on concentration distribution will be magnified in these systems. On the other hand, these biofluids are viscoelastic and show extraordinary flow behaviors, not existing in Newtonian fluids and adopting appropriate constitutive equations these exotic flow behaviors... 

    Numerical Simulation and Analysis of Electrokinetic Micromixer

    , M.Sc. Thesis Sharif University of Technology Raffiee, Amir Hossein (Author) ; Saidi, Mohammad Said (Supervisor)
    Lab-On-A-Chip is a micro-scale system which utilizes specific tools in order to operate detection tests on samples. One of the most important components of these devices is micromixers which is responsible for appropriate mixing of samples in short period of time. The biggest problem associated to the mixing in micro-scale is the regime that the flow takes during the process. Due to the small dimensions of micromixers the induced flow stream resides in the range of laminar flows and consequently the mixing is conducted solely by diffusion mechanism which is either time-taking or requires long micro-channel that causes the high cost of fabrication. In order to improve the mixing process two... 

    Analysis and Design of an Electrokinetically-driven Micro-Mixer

    , M.Sc. Thesis Sharif University of Technology Anbari, Ali Mohammad (Author) ; Shafii, Mohammad Behshad (Supervisor) ; Saeedi, Mohammad Saeed (Supervisor)
    A Lab-On-A-Chip is a micro-scale system whic h utilizes some micro-scale components in order to implement detection tests on samples. One of the most important components of a lab-on-a-chip device is the micro-mixer, which is responsible for appropriately mixing of samples in a short period of time. The biggest problem relevant to mixing in micro scales is that since as the viscous forces are dominant in micro scale and dimensions are small, it is impractical to mix fluids via turbulence, and consequently mixing process is performed by diffusion mechanism. Two major strategies are being used in order to improve the mixing performance and two groups of micro-mixers, passive and active types,... 

    Continuous Catalytic Synthesis of Medicine Through a Micro-Reactor System

    , M.Sc. Thesis Sharif University of Technology Jahangirifard, Shayan (Author) ; Kazemeini, Mohammad (Supervisor) ; Hosseinpour, Vahid (Co-Supervisor)
    In the past decades, the production of various active pharmaceutical ingredients in batch processes was common. But today, the approach of pharmaceutical companies has changed and the use of the equipment and continuous processes such as microreactors has become common for reasons of safety, better mass and heat transfer, reduction of operators, and ease of scale-up. Unlike many top-selling drugs such as Ibuprofen and Artemisinin, Clopidogrel, the world's third best-selling drug needed by cardiac patients, has been manufactured only in batch processes. Due to the increase in the average age of the population, the urgent need for the use of Plavix (clopidogrel) has increased in recent years.... 

    Continuous Synthesis of Medicine Utilizing Catalyst Through a Microreactor System

    , M.Sc. Thesis Sharif University of Technology Erfani Gahrooei, Amir Reza (Author) ; Kazemeini, Mohammad (Supervisor) ; Khorasheh, Farhad (Supervisor) ; Hosseinpour, Vahid (Co-Supervisor)
    Nowadays, the use of microreactors is receiving a great deal of attention due to the unique characteristics of such systems, such as high surface-to-volume ratio, low material loss, greater safety, and minimizing mass and heat transfer limitations. In this study, the optimization of the continuous-flow synthesis of Plavix by Cu-MOF heterogeneous catalyst utilizing a glass microreactor was investigated. Structural characteristics of the catalyst were investigated using X-ray diffraction spectroscopy (XRD), Fourier-transform infrared spectroscopy (FTIR), Scanning electron microscopy (SEM), and BET surface area studies to describe the structure and morphology of the catalyst. In order to build... 

    Modeling and Simulation of Micromixing Phenomenon in a New Double-Spinning-Disc Reactor

    , M.Sc. Thesis Sharif University of Technology Balaghi Inaloo, Majid (Author) ; Molaei Dehkordi, Asghar (Supervisor)
    Mixing efficiency is an important performance indicator in many chemical reactors. In the present study, using a computational fluid dynamics model, the quality of micromixing in a double-disk-spinning reactor with the ability to rotate both disks using a fast iodide-iodate competitive reaction has been investigated. The purpose of this study was to investigate the effect of operational parameters such as the speed and direction of rotation of disks, radius and number of entry points of one feed, distance between disks, volumetric flow of feed, feed inlet nozzle diameter and acid concentration (H+) on quality of micromixing. The simulation results show that by increasing the rotation speed... 

    Isolation of Circulating Tumor Cells Using an Aptamer-Based Microfluidic Device

    , M.Sc. Thesis Sharif University of Technology Abouali, Hesam (Author) ; Vosoughi, Manouchehr (Supervisor) ; Alemzadeh, Iran (Supervisor)
    Cancer is a major cause of mortality worldwide, with a disease burden estimated to grow over the coming decades. Circulating tumor cells (CTCs) are rare cancer cells released from the primary or metastatic tumors and transported though the peripheral circulatory system to their specific secondary locations. The presence of CTCs in a cancer patient’s blood has been used as a prognostic biomarker, with lower CTC count correlating with greater overall survival. In spite of its clinical potential, the isolation and detection of CTCs has been a challenging task due to its rare presence amongst other blood cells (as low as 1–10 CTCs per billions of blood cells) and variability in terms of both... 

    Experimental Investigation and Modeling of Nanoparticles Synthesis by Reactive Precipitation and Using a Spinning Disk Reactor

    , Ph.D. Dissertation Sharif University of Technology Bagheri Farahani, Hamed (Author) ; Shahrokhi, Mohammad (Supervisor) ; Molaei Dehkordi, Asghar (Supervisor)
    In this research work, to enhance the performance of the conventional spinning disk reactors, a novel type of spinning disk reactor has been proposed and tested successfully through the synthesis of barium sulfate nanoparticles by means of the reactive precipitation. This reactor consists of two coaxial rotating disks placed horizontally in a cylindrical chamber. The experimental results clearly indicate the capability of the proposed reactor in the synthesis of nanoparticles with the smaller mean particle size and the narrower particle size distribution compared to those obtained in various process intensification devices such that barium sulfate nanoparticles with a mean particle size of... 

    Production of Vegetable Oil Biodiesel by Heterogeneous Catalytic Trans-Esterification Method in Micro-Reactor

    , M.Sc. Thesis Sharif University of Technology Piran, Samira (Author) ; Kazemeini, Mohammad (Supervisor) ; Mohammadi, Ali Asghar (Supervisor)
    The purpose of this study is to study heterogeneous nanocatalysts for the production of biofuels by the method of exchange of styrene using oil and methanol as a fossil fuel alternative. Preparation of nanocatalysts, performing characteristic tests and investigating the reaction in different operating conditions in the batch reactor has already been studied. Therefore, in this study, the production of biodiesel fuel using the trans-esterification of canola oil with nanocatalysts in the micro-reactor reactor will be discussed. Previously, a heterogeneous catalyst (lithium based on calcium-lanthanum) was constructed using a co-incineration method and a wet inoculum, and as active and stable... 

    Modeling active micromixers with multiple microstirrers using smoothed particle hydrodynamics

    , Article Scientia Iranica ; Vol. 21, issue. 4 , 2014 , pp. 1390-1402 ; ISSN: 10263098 Jafarian, A ; Pishevar, A ; Saidi, M. S ; Sharif University of Technology
    The smoothed particle hydrodynamics method is used to explore the effects of design parameters on the mixing efficiency of two types of active micromixer. First, the complex flow field and the mixing process of two separated fluids in a square mixing chamber with nine symmetric microstirrers are simulated. The influence of design parameters, such as the microstirrer rotation arrangement and the angular velocity of the microstirrer, on the mixing performance, is investigated. The mixing index parameter on ten control points is calculated and the average mixing index is compared for different cases. Simulations illustrate that the rotation arrangement of microstirrers is a key parameter in the... 

    A new scheme for improving the mixing efficiency in micro scale

    , Article ASME 2011 9th International Conference on Nanochannels, Microchannels, and Minichannels, ICNMM 2011 ; Volume 1 , 2011 , Pages 183-191 ; 9780791844632 (ISBN) Anbari, A. M ; Haroutunian, A ; Saidi, M. S ; Shafii, M. B ; Sharif University of Technology
    Generally speaking, most micro-fluidic mixing systems are limited to the low Reynolds number regime in which diffusion dominates convection, and consequently the mixing process tends to be slow and it takes a relatively long time to have two fluids completely mixed. Therefore, rapid mixing is essential in micro-fluidic systems. In order to hasten the mixing process in micro scale, in this study we come up with a novel scheme for a two dimensional micro-fluidic mixer which encompasses three pairs of electrodes, one pair embedded in the mixing chamber and two pairs located in the micro-channels before and after the mixing chamber. The width of the middle pair is assumed to be twice of the... 

    A depthwise averaging solution for cross-stream diffusion in a Y-micromixer by considering thick electrical double layers and nonlinear rheology

    , Article Microfluidics and Nanofluidics ; Volume 19, Issue 6 , 2015 , Pages 1297-1308 ; 16134982 (ISSN) Ahmadian Yazdi, A ; Sadeghi, A ; Saidi, M. H ; Sharif University of Technology
    Springer Verlag  2015
    Both nonlinear rheology and finite EDL thickness effects on the mixing process in an electroosmotically actuated Y-sensor are being investigated in this paper, utilizing a depthwise averaging method based on the Taylor dispersion theory. The fluid rheological behavior is assumed to obey the power-law viscosity model. Analytical solutions are obtained assuming a large channel width to depth ratio for which a 1-D profile can efficiently describe the velocity distribution. Full numerical simulations are also performed to determine the applicability range of the analytical model, revealing that it is able to provide accurate results for channel aspect ratios of ten and higher and quite... 

    Electrokinetic mixing at high zeta potentials: Ionic size effects on cross stream diffusion

    , Article Journal of Colloid and Interface Science ; Volume 442 , 2015 , Pages 8-14 ; 00219797 (ISSN) Ahmadian Yazdi, A ; Sadeghi, A ; Saidi, M. H ; Sharif University of Technology
    Academic Press Inc  2015
    The electrokinetic phenomena at high zeta potentials may show several unique features which are not normally observed. One of these features is the ionic size (steric) effect associated with the solutions of high ionic concentration. In the present work, attention is given to the influences of finite ionic size on the cross stream diffusion process in an electrokinetically actuated Y-shaped micromixer. The method consists of a finite difference based numerical approach for non-uniform grid which is applied to the dimensionless form of the governing equations, including the modified Poisson-Boltzmann equation. The results reveal that, neglecting the ionic size at high zeta potentials gives...