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Smart pectin-based superabsorbent hydrogel as a matrix for ibuprofen as an oral non-steroidal antiinflammatory drug delivery
, Article Starch/Staerke ; Volume 61, Issue 3-4 , 2009 , Pages 173-187 ; 00389056 (ISSN) ; Barzegar, S ; Sharif University of Technology
2009
Abstract
The purpose of this study was to produce an intelligent superabsorbent polymer (SAP) to be used as a pH sensitive matrix for the controlled delivery of drugs. Novel types of highly swelling SAPs were prepared by grafting crosslinked acrylic acid-co-acrylamide (AA-co-AAm) chains onto pectin by free-radical polymerization. The superabsorbent formation was confirmed by Fourier transform infrared spectroscopic (FT-IR) and scanning electron microscopy (SEM). The controlled release behavior of ibuprofen (IBU) from the superabsorbent polymer was investigated. SAP structural-property relationships that affect its controlled release behavior were determined. Analysis of the results indicated that it...