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    Using the direct simulation Monte Carlo method to study the effect of wall temperature variation on gas mixing evolution through micro T-mixers

    , Article 11th International Energy Conversion Engineering Conference ; 2013 Darbandi, M ; Sabouri, M ; Lekzian, E ; Schneider, G. E ; Sharif University of Technology
    2013
    Abstract
    In this work, we study the gas mixing behavior in a micro T-mixer using the direct simulation Monte Carlo (DSMC) method. The gas mixing process is monitored through a T-mixer, which is fed by two different CO and N2 gases; flowing into the T-mixer through the upper and lower inlets. We investigate the effects of axial and lateral wall temperature gradients on the mixing evolution at different rarefaction levels. The achieved results show that any temperature difference between the channel walls would result in an increase in mixing length for the chosen wall temperature gradient ranges and the studies pressure cases. Our observations show that a positive temperature gradient toward the... 

    Three-dimensional numerical simulation of a novel electroosmotic micromixer

    , Article Chemical Engineering and Processing: Process Intensification ; Volume 119 , 2017 , Pages 25-33 ; 02552701 (ISSN) Shamloo, A ; Madadelahi, M ; Abdorahimzadeh, S ; Sharif University of Technology
    Elsevier B.V  2017
    Abstract
    Lab-on-a-chip (LOC) systems have been widely used in chemical and medical analyses. In this study, a novel T-shaped electroosmotic micromixer was simulated and the effects of different parameters on the mixing process were examined. These parameters include; inlet angle, number of conducting hurdles, arrangements of the hurdles, geometry of hurdles and chambers, aspect ratios of the channel cross-sectional profile, hurdle radius, and depth. It was found that the inlet angle has a direct influence on mixing index (σ). The effect of various number of hurdles (one, two, three and four hurdles) and their orientations was investigated. Simulations revealed that using two conducting hurdles is the... 

    Rarefaction effects on gas mixing in micro- and nanoscales

    , Article ASME 2016 5th International Conference on Micro/Nanoscale Heat and Mass Transfer, MNHMT 2016, 4 January 2016 through 6 January 2016 ; Volume 1 , 2016 ; 9780791849651 (ISBN) Darbandi, M ; Sabouri, M ; Heat Transfer Division ; Sharif University of Technology
    American Society of Mechanical Engineers  2016
    Abstract
    We present the rarefaction effects on diffusive mass transport in micro- and nanoscales using the results of direct simulation Monte Carlo DSMC method. Unlike the previous investigations, the momentum and heat contributions are eliminated from the computations via uniform velocity, pressure, and temperature field considerations. The effects of global Knudsen number on the diffusion phenomenon are studied for the same Peclet number and a unique mixer shape. The results indicate that there is considerable weakening in diffusion mechanism for high Knudsen number cases. As a result, the non-dimensional diffusive mass fluxes would decrease and the non-dimensional mixing length would increase as... 

    Quantifying the direct influence of diffusive mass transfer in rarefied gas mixing simulations

    , Article Journal of Fluids Engineering, Transactions of the ASME ; Volume 140, Issue 3 , March , 2018 ; 00982202 (ISSN) Darbandi, M ; Sabouri, M ; Sharif University of Technology
    American Society of Mechanical Engineers (ASME)  2018
    Abstract
    This work utilizes the direct simulation Monte Carlo (DSMC) calculations and examines the influence of rarefication on the mixing length and effective diffusion coefficient in a two-species mixing problem. There have been efforts in past rarefied mixing flow studies to bridge between the mixing evolution rate and Knudsen number. A careful review of those efforts shows that the past derived relations did not determine the weights of Reynolds (or Peclet) number in the rarefaction influences. Although they indicated that an increase in Knudsen would decrease the mixing length, such reductions were primarily due to the Reynolds (or Peclet) reduction. Therefore, those studies could not explicitly... 

    Parametric study on mixing process in an in-plane spiral micromixer utilizing chaotic advection

    , Article Analytica Chimica Acta ; Volume 1022 , 2018 , Pages 96-105 ; 00032670 (ISSN) Vatankhah, P ; Shamloo, A ; Sharif University of Technology
    Abstract
    Recent advances in the field of microfabrication have made the application of high-throughput microfluidics feasible. Mixing which is an essential part of any miniaturized standalone system remains the key challenge. This paper proposes a geometrically simple micromixer for efficient mixing for high-throughput microfluidic devices. The proposed micromixer utilizes a curved microchannel (spiral microchannel) to induce chaotic advection and enhance the mixing process. It is shown that the spiral microchannel is more efficient in comparison to a straight microchannel, mixing wise. The pressure drop in the spiral microchannel is only slightly higher than that in the straight microchannel. It is... 

    Numerical simulation of mixing and heat transfer in an integrated centrifugal microfluidic system for nested-PCR amplification and gene detection

    , Article Sensors and Actuators, B: Chemical ; Volume 283 , 2019 , Pages 831-841 ; 09254005 (ISSN) Naghdloo, A ; Ghazimirsaeed, E ; Shamloo, A ; Sharif University of Technology
    Elsevier B.V  2019
    Abstract
    Nucleic acid amplification via polymerase chain reaction (PCR) is one of the essential and powerful methods used in a myriad of bio-assays in clinical laboratories. Application of microfluidic devices in biologically-related processes like PCR can result in the usage of less volume of reactant samples and reduce the processing time. By implementing PCR systems on centrifugal microfluidic platforms, automation and portability can be easily achieved. Although several methods have been developed, most of them are still dealing with challenges of the required high processing time. This study presents the numerical simulation of a fully automated PCR system with the goal of enhancing the mixing... 

    Numerical simulation of centrifugal serpentine micromixers and analyzing mixing quality parameters

    , Article Chemical Engineering and Processing: Process Intensification ; Volume 104 , 2016 , Pages 243-252 ; 02552701 (ISSN) Shamloo, A ; Madadelahi, M ; Akbari, A ; Sharif University of Technology
    Elsevier, B.V  2016
    Abstract
    Centrifugal microfluidics or the Lab on a CD (LOCD) has developed vast applications in biomedical researches and analyses. Fluid mixing is an application of the LOCD. In this paper, multiple centrifugal micromixers were simulated. Various parameters were originally presumed to have an effect on mixing performance. These parameters include inlet angle, angular velocity, cross-sectional profile, perpendicular length ratio and the number of channels in series. They were each analyzed through simulations. It was gathered that the inlet angle does not significantly affect the mixing quality. Increasing angular velocity steadily increases mixing quality for all geometries. The vertical triangular... 

    Numerical simulation for efficient mixing of newtonian and non-Newtonian fluids in an electro-osmotic micro-mixer

    , Article Chemical Engineering and Processing: Process Intensification ; Volume 107 , 2016 , Pages 11-20 ; 02552701 (ISSN) Shamloo, A ; Mirzakhanloo, M ; Dabirzadeh, M. R ; Sharif University of Technology
    Elsevier  2016
    Abstract
    The present study, deals with a new mixing technique using a two-phase electrode array, which is charged with alternating current (AC) signals, located in specific parts of the geometry. This significantly contributes to a chaotic mixing mechanism using a low amplitude AC voltage within a micro-channel. Study analysis demonstrates that the optimization of the effective parameters such as geometrical features, voltage amplitude, fluid inlet velocity, AC frequency and phase lag for a defined fluid can lead to an optimum and highly efficient mixer by considerably increasing disturbances in a primary highly ordered laminar flow. Three different geometries of micro mixer are studied; one-ring... 

    Multiphysics analysis and practical implementation of a soft μ-actuator- based microfluidic micromixer

    , Article Journal of Microelectromechanical Systems ; Volume 29, Issue 2 , 2020 , Pages 268-276 Annabestani, M ; Azizmohseni, S ; Esmaeili Dokht, P ; Bagheri, N ; Aghassizadeh, A ; Fardmanesh, M ; Sharif University of Technology
    Institute of Electrical and Electronics Engineers Inc  2020
    Abstract
    Electroactive-Polymers (EAPs) are one of the best soft $mu $ -actuators with great biomedical applications. Ionic ones (i-EAPs) have more promising features and have adequate potential for using in the active microfluidic devices. Here, as a case study, we have designed and fabricated a microfluidic micromixer using an i-EAP named Ionic Polymer-Metal Composite (IPMC). In microfluidics, active devices have more functionality but due to their required facilities are less effective for Point of Care Tests (POCTs). In the direction of solving this paradox, we should use some active components that they need minimum facilities. IPMC can be one of these components, hence by integrating the IPMC... 

    Modeling active micromixers with multiple microstirrers using smoothed particle hydrodynamics

    , Article Scientia Iranica ; Vol. 21, issue. 4 , 2014 , pp. 1390-1402 ; ISSN: 10263098 Jafarian, A ; Pishevar, A ; Saidi, M. S ; Sharif University of Technology
    Abstract
    The smoothed particle hydrodynamics method is used to explore the effects of design parameters on the mixing efficiency of two types of active micromixer. First, the complex flow field and the mixing process of two separated fluids in a square mixing chamber with nine symmetric microstirrers are simulated. The influence of design parameters, such as the microstirrer rotation arrangement and the angular velocity of the microstirrer, on the mixing performance, is investigated. The mixing index parameter on ten control points is calculated and the average mixing index is compared for different cases. Simulations illustrate that the rotation arrangement of microstirrers is a key parameter in the... 

    Mixing performance of T, Y, and oriented Y-micromixers with spatially arranged outlet channel: evaluation with Villermaux/Dushman test reaction

    , Article Microsystem Technologies ; Volume 23, Issue 8 , 2017 , Pages 3117-3130 ; 09467076 (ISSN) Rahimi, M ; Azimi, N ; Parsamogadam, M. A ; Rahimi, A ; Masahy, M. M ; Sharif University of Technology
    Springer Verlag  2017
    Abstract
    This study aims to investigate the micromixing performance of three basic types of spatial shaped micromixers. New configurations of T, Y, and oriented Y-spatial mixers were designed with change in the angles of the confluence and the outlet channel to achieve the efficient micromixing. These micromixers offer advantages that are not attainable with the typical types of these mixers. Experimental tests were carried out in the laminar flow regime and the mixing efficiency was evaluated using Villermaux/Dushman test reaction. The geometries of the channels were cylindrical with the length of 30 mm and the diameter of 800 μm. The experimental results show that the angle of outlet channel has a... 

    Mixing performance of T, Y, and oriented Y-micromixers with spatially arranged outlet channel: evaluation with villermaux/dushman test reaction

    , Article Microsystem Technologies ; 2016 , Pages 1-14 ; 09467076 (ISSN) Rahimi, M ; Azimi, N ; Parsamogadam, M. A ; Rahimi, A ; Masahy, M. M ; Sharif University of Technology
    Springer Verlag  2016
    Abstract
    This study aims to investigate the micromixing performance of three basic types of spatial shaped micromixers. New configurations of T, Y, and oriented Y-spatial mixers were designed with change in the angles of the confluence and the outlet channel to achieve the efficient micromixing. These micromixers offer advantages that are not attainable with the typical types of these mixers. Experimental tests were carried out in the laminar flow regime and the mixing efficiency was evaluated using Villermaux/Dushman test reaction. The geometries of the channels were cylindrical with the length of 30 mm and the diameter of 800 μm. The experimental results show that the angle of outlet channel has a... 

    Low power receiver with merged N-path LNA and mixer for MICS applications

    , Article AEU - International Journal of Electronics and Communications ; Volume 117 , 2020 Beigi, A ; Safarian, A ; Sharif University of Technology
    Elsevier GmbH  2020
    Abstract
    In this paper, a low power receiver for medical implant communication service (MICS) is presented. Low power design is vital in the MICS applications since the implanted chip has to work for a long time without the need to change its battery. As a result, a merged N-path low noise amplifier (LNA) and mixer block is proposed. In this structure, the LNA and down-conversion mixer share a transconductance to lower the overall power consumption. An N-path feedback is utilized around the shared transconductance not only to improve the LNA selectivity and relax the linearity requirements but also to downconvert the radio frequency (RF) component and create the intermediate frequency (IF) signal. In... 

    Investigation of a Novel Microfluidic Device for Label-Free Ferrohydrodynamic Cell Separation on a Rotating Disk

    , Article IEEE Transactions on Biomedical Engineering ; Volume 67, Issue 2 , 2020 , Pages 372-378 Shamloo, A ; Besanjideh, M ; Sharif University of Technology
    IEEE Computer Society  2020
    Abstract
    Negative magnetophoresis is a novel and attractive method for continuous microparticle sorting inside a magnetic medium. In this method, diamagnetic particles are sorted based on their sizes using magnetic buoyancy force and without any labeling process. Although this method provides some attractive features, such as low-cost fabrication and ease of operation, there are some obstacles that adversely affect its performance, especially for biological applications. Most types of magnetic media, such as ferrofluids, are not biocompatible, and the time-consuming process of sample preparation can be threatening to the viability of the cells within the sample. Furthermore, in this method, both the... 

    Enhancing active electro-kinetic micro-mixer efficiency by introducing vertical electrodes and modifying chamber aspect ratio

    , Article Chemical Engineering and Processing - Process Intensification ; Volume 142 , 2019 ; 02552701 (ISSN) Maleki Bagherabadi, K ; Sani, M ; Saidi, M. S ; Sharif University of Technology
    Elsevier B.V  2019
    Abstract
    Micro-mixers are considered as vital components of Micro Total Analysis systems (μTAS). Major objective in the design of micro-mixers is achieving high mixing quality in short mixing times. In this paper, numerical simulation of some micro-mixer designs has been carried out to understand the detailed flow pattern and thereby to propose modifications for improving mixing efficiency. It is well known that inducing convection will provide turbulent like behavior with corresponding mixing enhancement. In micro systems to drive the flow, electro-osmotic force is usually used by introducing electrodes. In this work, mixing electrodes have been implemented to induce convection and eddies. This... 

    Electrokinetic mixing at high zeta potentials: Ionic size effects on cross stream diffusion

    , Article Journal of Colloid and Interface Science ; Volume 442 , 2015 , Pages 8-14 ; 00219797 (ISSN) Ahmadian Yazdi, A ; Sadeghi, A ; Saidi, M. H ; Sharif University of Technology
    Academic Press Inc  2015
    Abstract
    The electrokinetic phenomena at high zeta potentials may show several unique features which are not normally observed. One of these features is the ionic size (steric) effect associated with the solutions of high ionic concentration. In the present work, attention is given to the influences of finite ionic size on the cross stream diffusion process in an electrokinetically actuated Y-shaped micromixer. The method consists of a finite difference based numerical approach for non-uniform grid which is applied to the dimensionless form of the governing equations, including the modified Poisson-Boltzmann equation. The results reveal that, neglecting the ionic size at high zeta potentials gives... 

    Effect of out-of-band blockers on the required linearity, phase noise, and harmonic rejection of sdr receivers without input saw filter

    , Article IEEE Transactions on Microwave Theory and Techniques ; Volume 66, Issue 11 , 2018 , Pages 4913-4926 ; 00189480 (ISSN) Rasekh, A ; Bakhtiar, M. S ; Sharif University of Technology
    Institute of Electrical and Electronics Engineers Inc  2018
    Abstract
    The required linearity of wideband receivers for applications, such as software-defined radio in the absence of input surface-acoustic wave (SAW) filters, is studied. It is shown that the required linearity of wideband SAW-less receivers is surprisingly higher than what has been commonly assumed. For these receivers, although the out-of-band blockers can reduce the compression point of the receiver, they can also potentially generate interferers that appear in the desired frequency band, resulting in higher noise floor and signal corruption. The required out-of-band IIP2 and IIP3 of low-noise amplifier (LNA) and mixer for single and concurrent applications are analytically derived. The... 

    Down-conversion self-oscillating mixer by using CMOS technology

    , Article Proceedings - 2012 IEEE 8th International Colloquium on Signal Processing and Its Applications, CSPA 2012 ; 2012 , Pages 33-36 ; 9781467309615 (ISBN) Kouchaki, M ; Zahedi, A ; Sabaghi, M ; Ameri, S. R. H ; Niyakan, M ; Sharif University of Technology
    2012
    Abstract
    In this paper a self-oscillating mixer is presented fundamental signal generated by the oscillator subcircuit in the mixing process. The oscillator core consumes 3mA of current from a 1.8 V DC supply and results in an output power of -0.867 dBm per oscillator, and a measured phase noise of -91, -102 and -108 dBc/Hz at 100 KHz, 600 KHz and 1 MHz from the carrier, respectively. In the mixing process the proposed mixer achieved IIP3 of 0 dBm with conversation gain of 1.93 dB. The circuit was designed and simulated in 0.18-μm CMOS technology by ADS2010  

    Detail study on improving micro/nano gas mixer performances in slip and transitional flow regimes

    , Article Sensors and Actuators, B: Chemical ; Volume 218 , October , 2015 , Pages 78-88 ; 09254005 (ISSN) Darbandi, M ; Sabouri, M ; Sharif University of Technology
    Elsevier  2015
    Abstract
    The mixer geometry has substantial effect on mixing performance of different micro/nanomixers. Despite past numerous studies dedicated to mixing of liquid flow streams, there are less efforts to investigate the geometry effects on gas mixing performances. In this work, we focus on gas-gas mixing through different micro/nanoscale mixers under slip and transitional flow regimes. We use the direct simulation Monte Carlo (DSMC) method to provide accurate and reliable results in such flow regimes. To extend our study, we implement different geometrical parameters in our consideration including the mixer size, the impact angle between two incoming gas streams, and the contraction height located in... 

    Design and simulation of an integrated centrifugal microfluidic device for CTCs separation and cell lysis

    , Article Micromachines ; Volume 11, Issue 7 , July , 2020 Nasiri, R ; Shamloo, A ; Akbari, J ; Tebon, P ; Dokmeci, M. R ; Ahadian, S ; Sharif University of Technology
    MDPI AG  2020
    Abstract
    Separation of circulating tumor cells (CTCs) from blood samples and subsequent DNA extraction from these cells play a crucial role in cancer research and drug discovery. Microfluidics is a versatile technology that has been applied to create niche solutions to biomedical applications, such as cell separation and mixing, droplet generation, bioprinting, and organs on a chip. Centrifugal microfluidic biochips created on compact disks show great potential in processing biological samples for point of care diagnostics. This study investigates the design and numerical simulation of an integrated microfluidic device, including a cell separation unit for isolating CTCs from a blood sample and a...