Sharif Digital Repository

The main scope of this study is to analyse muscle-driven forward dynamics simulation of stair locomotion to understand the functional differences of individual muscles during the movement. A static optimization was employed to minimize a performance criterion based on the muscle energy consumption to resolve muscle redundancy during forward dynamics simulation. The proposed method was employed to simulate a musculoskeletal system with ten degrees of freedom in the sagittal plane and containing 18 Hill-type musculotendon actuators per leg. Simulation results illustrated that simulated joint kinematics closely tracked experimental quantities with root-mean-squared errors less than 1 degree. In... 

Body weight is influenced by both food intake and energy expenditure. Acylated ghrelin enhances appetite, and its circulating level is suppressed by Growth Hormone. Data on the acylated ghrelin responses to exercise of different intensities in obese individuals are currently not available. This study examined the effects of an intermittent exercise protocol on acylated ghrelin levels and hunger ratings in obese people. Nine inactive male ran on the treadmill at 0900 with progressive intensities of 50, 60, 70, and 80% of VO2max for 10, 10, 5, and 2 min respectively. Blood samples were collected before the exercise at 0845 (-15 min as the resting values), after each workload (10, 23, 31, and... 

Purpose: According to the conventional arch model of the pelvis, stability of the sacroiliac joints may require a predominance of form and force closure mechanisms: the greater the vertical shear force at the sacroiliac joints, the greater the reliance on self-bracing by horizontally or obliquely oriented muscles (such as the internal oblique). But what happens to the arch model when a person stands on one leg? In such cases, the pelvis no longer has imposts, leaving both the arch, and the arch model theory, without support. Do lumbopelvic muscle activation patterns in one-legged stances under load suggest compatibility with a different model? This study compares lumbopelvic muscle... 

A wide range of loading conditions involving external forces with varying magnitudes, orientations and locations are encountered in daily activities. Here we computed the effect on trunk biomechanics of changes in force location (two levels) and orientation (5 values) in 4 subjects in upright standing while maintaining identical external moment of 15. Nm, 30. N. m or 45. Nm at the L5-S1. Driven by measured kinematics and gravity/external loads, the finite element models yielded substantially different trunk neuromuscular response with moderate alterations (up to 24% under 45 Nm moment) in spinal loads as the load orientation varied. Under identical moments, compression and shear forces at... 

Despite development of accurate musculoskeletal models for human lumbar spine, the methods for prediction of muscle activity patterns in movements lack proper association with corresponding sensorimotor integrations. This paper uses the directional information of the Jacobian of the musculoskeletal system to orchestrate adaptive critic-based fuzzy neural controller modules for controlling a complex nonlinear redundant musculoskeletal system. The proposed controller is used to control a 3D 3-degree of freedom (DOF) musculoskeletal model of trunk, actuated by 18 muscles. The controller is capable of learning to control from sensory information, without relying on pre-assumed model parameters.... 

With increasing importance of exoskeletons as rehabilitation apparatuses, suitable and delicate control strategies has received much attention. In order to control the exoskeleton, there should be a complete understanding of torques produced by the limb itself which makes the musculoskeletal modeling of the limb essential but also complex. In addition, the musculoskeletal model can be used to discover the user's desired movement to control the exoskeleton. In this paper a complete musculoskeletal model for the elbow with two degrees of freedom is developed and simulated. Next the model is used to determine user's desired movement. Finally based on this evaluation, an exoskeleton model is... 

BACKGROUND AND OBJECTIVES: It is suggested that activation of the transverse abdominis muscle has a stabilizing effect on the lumbar spine by raising intra-abdominal pressure without added disc compression. However, its feedforward activity has remained a controversial issue. In addition, research regarding bilateral activation of trunk muscles during a unilateral arm movement is limited. The aim of this study was to evaluate bilateral anticipatory activity of trunk muscles during unilateral arm flexion.MATERIALS AND METHODS: Eighteen healthy subjects (aged 25 ± 3.96 years) participated in this study and performed 10 trials of rapid arm flexion in response to a visual stimulus. The... 

An anatomically detailed eighteen-rotational-degrees-of-freedom model of the human spine using optimization constrained to equilibrium and stability requirements is developed and used to simulate several symmetric tasks in upright and flexed standing postures. Predictions of this stability and kinematics-driven (S. +. KD) model for trunk muscle forces and spine compressive/shear loads are compared to those of our existing kinematics-driven (KD) model where both translational and rotational degrees-of-freedom are included but redundancy is resolved using equilibrium conditions alone. Unlike the KD model, the S. +. KD model predicted abdominal co-contractions that, in agreement with... 

The main goal of this study is to investigate the role of vascular graft thickness in wall stress gradient in anastomosis region. Atherosclerosis is a common heart disease causes high mortality rates every year. The gold standard treatment of atherosclerosis is replacing with autologous vein extracted from patient's body. Since proper autologous vein is limited, researchers have made efforts to achieve compliance engineered blood vessels. Mechanical stress has great effect on both smooth muscle cells and endothelial cells and it is considered as a stimulus in plaque formation. In this study, we evaluate the role of thickness in wall stress of anastomosis region. For this purpose, two... 

Background: Most dentists complain of musculoskeletal disorders which can be caused by prolonged static posture lack of suitable rest and other physical and psychological problems. Objective: We evaluated a chair with a new ergonomic design which incorporated forward leaning chest and arm supports. Methods: The chair was evaluated in the laboratory during task simulation and EMG analysis on 12 students and subjectively assessed by 30 professional dentists using an 18-item questionnaire. EMG activity of right and left trapezius muscles for 12 male students with no musculoskeletal disorders was measured while simulating common tasks like working on the teeth of the lower jaw. Results:... 

In spite of earlier experimental and modeling studies, the relative role of the intra-abdominal pressure (IAP) in spine mechanics has remained controversial. This study employs simple analytical and finite element (FE) models of the spine and its surrounding structures to investigate the contribution of IAP to spinal loading and stability. The analytical model includes the abdominal cavity surrounded by muscles, lumbar spine, rib cage and pelvic ring. The intra-abdominal cavity and its surrounding muscles are represented by a thin deformable cylindrical membrane. Muscle activation levels are simulated by changing the Young's modulus of the membrane in the direction of muscle fibers, yielding... 

This research presents virtual prototyping and performance evaluation of a series elastic torque actuator developed for augmenting lower extremity exoskeletal systems employing biomechanical framework. For this purpose, experimental kinematical data of the lower extremity were collected for walking and backpack load carrying. Forward dynamics simulation of the movements under investigation is performed in a biomechanical framework consisting of a musculoskeletal model with ten degrees-of-freedom actuated by eighteen Hill-type musculotendon actuators per leg to perform the muscle functional analysis. Muscle torque analysis results employed for optimal design and selection of components in the... 

The complexity associated with musculoskeletal modeling, simulation, and neural control of the human spine is a challenging problem in the field of biomechanics. This paper presents a novel method for simulation of a 3D trunk model under control of 48 muscle actuators. Central pattern generators (CPG) and artificial neural network (ANN) are used simultaneously to generate muscles activation patterns. The parameters of the ANN are updated based on a novel learning method used to address the kinetic redundancy due to presence of 48 muscles driving the trunk. We demonstrated the feasibility of the proposed method with numerical simulation of experiments involving rhythmic motion between upright... 

Muscle force partitioning methods and musculoskeletal system simplifications are key modeling issues that can alter outcomes, and thus change conclusions and recommendations addressed to health and safety professionals. A critical modeling concern is the use of single-joint equilibrium to estimate muscle forces and joint loads in a multi-joint system, an unjustified simplification made by most lumbar spine biomechanical models. In the context of common occupational tasks, an EMG-assisted optimization method (EMGAO) is modified in this study to simultaneously account for the equilibrium at all lumbar joints (M-EMGAO). The results of this improved approach were compared to those of its... 

Marvelous bending/straightening effects of two-way shape memory alloy (TWSMA) help their employment in design and manufacturing of new medical appliances. Constrained ageing with bending load scheme can induce two-way shape memory effect (TWSME). Scanning electron microscopic (SEM) analysis, electrical resistivity measurement (ERM) and differential scanning calorimetry (DSC) are employed to determine the property change due to flat strip constrained aging. Results show that flat-annealing prior to the aging shifts NiTi transformations temperatures to higher values. Superelastic behavior of the as-received/flat- annealed/aged samples with more adequate transition temperatures due to... 

Background Iatrogenic injuries to paraspinal muscles during posterior lumbar surgery cause a reduction in their contractile cross-sectional area and thus presumably their postoperative activation. This study investigates the effect of such intraoperative injuries on postoperative patterns of muscle activations and spinal loads during various activities using a combined modeling and in vivo MR imaging approach. Methods A three-dimensional, multi-joint, musculoskeletal model was used to estimate pre- and postoperative muscle forces and spinal loads under various activities in upright and flexed postures. According to our in vivo pre- and postoperative (∼ 6 months) measurements in six patients... 

A central problem in motor control is to understand how the many biomechanical degrees of freedom are coordinated to achieve a goal. A common assumption is that Central Nervous System (CNS) would minimize a performance index to achieve this goal which is called objective function. In this paper, two popular objective functions are utilized to design the optimal trajectory of trunk movements. A 3D computational method incorporated with 18 anatomically oriented muscles is used to simulate human trunk system. Inverse dynamics allows us to compute torque which is generated around Lumbosacral joint. This torque is divided among muscles by static stability-based optimization. Trunk movement from... 

In this study we utilize the concept of synergy formation as a simplifying control strategy to manage the high number of degrees of freedom presented in the maintenance of the posture of the shoulder joint. We address how to find the muscle synergy recruitment map to the biomechanical demands (biaxial external torque) during an isometric shoulder task. We use a numerical optimization based shoulder model to obtain muscle activation levels when a biaxial external isometric torque is exposed at the shoulder glenohumeral joint. In the numerical simulations, different shoulder torque vectors parallel to the horizontal plane are considered. For each selected direction for the torque, the... 

Background: Studying the kinematics of the ACL deficient (ACLD) knees, during different physiological activities and muscle contraction patterns, can improve our understanding of the joint's altered biomechanics due to ACL deficiency as well as the efficacy and safety of the rehabilitations exercises. Methods: Twenty-five male volunteers, including 11 normal and 14 unilateral ACLD subjects, participated in this study. The kinematics of the injured knees of the ACLD subjects was compared with their intact knees and the healthy group during passive flexion and isometric leg press with the knees flexed from full extension to 45° flexion, with 15° intervals. An accurate registration algorithm... 

This study investigates the effect of body acceleration on human cardiac function. Finite element analysis is conducted to simulate geometrical and mechanical properties of human heart. Heart geometrical modeling in three-dimension is performed by segmentation of cardiac MRI images. The nonlinear mechanical behavior of myocardium is modeled by Mooney-Rivlin, Polynomial, Ogden and Yeoh hyperelastic material models. Stress-strain curves of myocardial tissue are obtained from experimental compression tests on bovine heart samples. The experimental results are employed for the evaluation of material coefficients by the nonlinear least squares method. Among hyperelastic models, the Yeoh model...