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    Design a Microfluidics System for Drug Testing of Leukemia Patient's Bone Marrow Aspirate

    , M.Sc. Thesis Sharif University of Technology Rahimi, Ali (Author) ; Saidi, Mohammad Said (Supervisor)
    Abstract
    Cancer is one of the most causes of mortality in the world. Leukemia is a type of cancer initiated by the rapid proliferation of blood cells including WBCs, RBCs, and Platelets, that classified into four general types of AML, ALL, CML, and CLL. The main treatment of leukemia is chemotherapy. Because of many problems that patients have with this treatment and not so good results of chemotherapy, we design a microfluidic chip that can perform personalized medicine treatment for leukemia patients.This microchip consists of two main parts, Concentration Gradient Generator (CGG), and cell culture. CGG system is a tree CGG with two inlets and four outlets, which makes a linear concentration of... 

    The effects of movement speed on kinematic variability and dynamic stability of the trunk in healthy individuals and low back pain patients

    , Article Clinical Biomechanics ; Volume 30, Issue 7 , Aug , 2015 , Pages 682-688 ; 02680033 (ISSN) Asgari, M ; Sanjari, M. A ; Mokhtarinia, H. R ; Moeini Sedeh, S ; Khalaf, K ; Parnianpour, M ; Sharif University of Technology
    Elsevier Ltd  2015
    Abstract
    Background: Comparison of the kinematic variability and dynamic stability of the trunk between healthy and low back pain patient groups can contribute to gaining valuable information about the movement patterns and neuromotor strategies involved in various movement tasks. Methods: Fourteen chronic low back pain patients with mild symptoms and twelve healthy male volunteers performed repeated trunk flexion-extension movements in the sagittal plane at three different speeds: 20 cycles/min, self-selected, and 40 cycles/min. Mean standard deviations, coefficient of variation and variance ratio as variability measures; maximum finite-time Lyapunov exponents and maximum Floquet multipliers as... 

    A foreign body response-on-a-chip platform

    , Article Advanced Healthcare Materials ; Volume 8, Issue 4 , 2019 ; 21922640 (ISSN) Sharifi, F ; Htwe, S. S ; Righi, M ; Liu, H ; Pietralunga, A ; Yesil Celiktas, O ; Maharjan, S ; Cha, B. H ; Shin, S. R ; Dokmeci, M. R ; Vrana, N. E ; Ghaemmaghami, A. M ; Khademhosseini, A ; Zhang, Y. S ; Sharif University of Technology
    Wiley-VCH Verlag  2019
    Abstract
    Understanding the foreign body response (FBR) and desiging strategies to modulate such a response represent a grand challenge for implant devices and biomaterials. Here, the development of a microfluidic platform is reported, i.e., the FBR-on-a-chip (FBROC) for modeling the cascade of events during immune cell response to implants. The platform models the native implant microenvironment where the implants are interfaced directly with surrounding tissues, as well as vasculature with circulating immune cells. The study demonstrates that the release of cytokines such as monocyte chemoattractant protein 1 (MCP-1) from the extracellular matrix (ECM)-like hydrogels in the bottom tissue chamber... 

    Gut-on-a-chip: Current progress and future opportunities

    , Article Biomaterials ; Volume 255 , 2020 Ashammakhi, N ; Nasiri, R ; Barros, N. R. D ; Tebon, P ; Thakor, J ; Goudie, M ; Shamloo, A ; Martin, M. G ; Khademhosseni, A ; Sharif University of Technology
    Elsevier Ltd  2020
    Abstract
    Organ-on-a-chip technology tries to mimic the complexity of native tissues in vitro. Important progress has recently been made in using this technology to study the gut with and without microbiota. These in vitro models can serve as an alternative to animal models for studying physiology, pathology, and pharmacology. While these models have greater physiological relevance than two-dimensional (2D) cell systems in vitro, endocrine and immunological functions in gut-on-a-chip models are still poorly represented. Furthermore, the construction of complex models, in which different cell types and structures interact, remains a challenge. Generally, gut-on-a-chip models have the potential to... 

    A practical sensor-based methodology for the quantitative assessment and classification of chronic non specific low back patients (NSLBP) in clinical settings

    , Article Sensors (Switzerland) ; Volume 20, Issue 10 , 2020 Davoudi, M ; Shokouhyan, S. M ; Abedi, M ; Meftahi, N ; Rahimi, A ; Rashedi, E ; Hoviattalab, M ; Narimani, R ; Parnianpour, M ; Khalaf, K ; Sharif University of Technology
    MDPI AG  2020
    Abstract
    The successful clinical application of patient-specific personalized medicine for the management of low back patients remains elusive. This study aimed to classify chronic nonspecific low back pain (NSLBP) patients using our previously developed and validated wearable inertial sensor (SHARIF-HMIS) for the assessment of trunk kinematic parameters. One hundred NSLBP patients consented to perform repetitive flexural movements in five different planes of motion (PLM): 0◦ in the sagittal plane, as well as 15◦ and 30◦ lateral rotation to the right and left, respectively. They were divided into three subgroups based on the STarT Back Screening Tool. The sensor was placed on the trunk of each... 

    A hepatocellular carcinoma–bone metastasis-on-a-chip model for studying thymoquinone-loaded anticancer nanoparticles

    , Article Bio-Design and Manufacturing ; Volume 3, Issue 3 , 2020 , Pages 189-202 Sharifi, F ; Yesil Celiktas, O ; Kazan, A ; Maharjan, S ; Saghazadeh, S ; Firoozbakhsh, K ; Firoozabadi, B ; Zhang, Y. S ; Sharif University of Technology
    Springer  2020
    Abstract
    We report the development of a metastasis-on-a-chip platform to model and track hepatocellular carcinoma (HCC)–bone metastasis and to analyze the inhibitory effect of an herb-based compound, thymoquinone (TQ), in hindering the migration of liver cancer cells into the bone compartment. The bioreactor consisted of two chambers, one accommodating encapsulated HepG2 cells and one bone-mimetic niche containing hydroxyapatite (HAp). Above these chambers, a microporous membrane was placed to resemble the vascular barrier, where medium was circulated over the membrane. It was observed that the liver cancer cells proliferated inside the tumor microtissue and disseminated from the HCC chamber to the...