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    Entanglement and Decoherence in Optomechanical Systems Coupled through Photothermal Effects

    , Ph.D. Dissertation Sharif University of Technology Abdi, Mehdi (Author) ; Bahrampour, Alireza (Supervisor)
    Abstract
    Optomechanical systems have attracted considerable attention in the last decade. Such a raising prominence is mainly due to its capability in providing new insight into the quantum behavior of macroscopic objects and exploring the interface between quantum and classical mechanics. Alongside this fundamental quest, cavity optomechanics has many other benefits, ranging from very precise measurements on forces and positions to quantum information processing. In this thesis, we investigate quantum properties of such systems. Particularly, we study cooling of the mechanical resonator toward its ground state and the entanglement between this mechanical resonator and the cavity field. Cooling the... 

    Investigation of the Hybrid Structures based on Carbon Materials for Solar Steam Generation

    , Ph.D. Dissertation Sharif University of Technology Simayee, Maedeh (Author) ; Irajizad, Azam (Supervisor) ; Esfandiar, Ali (Supervisor)
    Abstract
    Two-dimensional nanostructures can significantly absorb solar irradiation, due to diverse energy levels, large effective surfaces, layered and porous structures with adjustable physical and chemical properties. Mono and multilayers of graphene, as the first isolated 2D materials with special band-structure of a zero-band gap, along with impressive optical properties, tunable light interaction, and adjustable optical properties by chemical doping or structural defects, have great potential for the next generation of nanophotonic devices. So, graphene is an appropriate candidate for absorption, frequent reflection, and energy conversion of electromagnetic waves at the frequency range of the... 

    An Experimental Study of Cancer Treatment Using Combined Hyperthermia and Chemotherapy Methods

    , Ph.D. Dissertation Sharif University of Technology Khafaji, Mona (Author) ; Vosoghi, Manoucher (Supervisor) ; Hormozinezhad, Mohammad Reza (Supervisor) ; Dinarvand, Rasoul (Supervisor) ; Iraji Zad, Azam (Co-Advisor)
    Abstract
    Cancer treatment is one of the most challenging issues of recent years. Extensive researches have been conducted in various fields of medicine, pharmacy, and medical physics in this regard. Today, considering nanotechnology developments, researchers believe that full cancer treatment is possible through the use of nano-systems designed with scientific background to overcome the defects of previous methods. In this research, the main purpose is to design and synthesize multifunctional hybrid nanostructures with favorable optical and magnetic properties providing a way to combine chemotherapy and thermal treatment. Accordingly, two different structures were designed and experimentally... 

    Study, Optimization and Construction of a Microfluidic Gene Amplification Device by Using Thin Film Layer Method

    , M.Sc. Thesis Sharif University of Technology Eslami, Sara Sadat (Author) ; Vosoughi, Manouchehr (Supervisor) ; Alemzadeh, Iran (Co-Supervisor) ; Shamloo, Amir (Co-Supervisor)
    Abstract
    Polymerase Chain Reaction (PCR) is a process in which a special piece of a gene is amplified millions of times over a short period. This method has been of paramount importance in different fields of research and has been applied for different applications. PCR requires thermal cycling, or repeated temperature changes between two or three discrete temperatures to amplify specific nucleic acid target sequences. To achieve such thermal cycling, conventional bench-top thermal cyclers generally use a metal heating block powered by Peltier elements or benefit from forced convection heat transfer. Due to the fact that these methods are time consuming, it seems that design and fabrication of a fast... 

    Design, Simulation and Construction of a Rapid Gene Amplification Microfluidic Device Using Polymerase Chain Reaction (PCR) Method

    , M.Sc. Thesis Sharif University of Technology Amadeh, Ali (Author) ; Shamloo, Amir (Supervisor)
    Abstract
    Polymerase chain reaction method is a conventional method for obtaining multiple copies of a specified segment in the DNA molecule and to amplify the DNA molecule itself. Therefore, this method has been of paramount importance in different fields of research and has been applied for different applications. PCR requires thermal cycling, or repeated temperature changes between two or three discrete temperatures to amplify specific nucleic acid target sequences. To achieve such thermal cycling, conventional bench-top thermal cyclers generally use a metal heating block powered by Peltier elements or benefit from forced convection heat transfer. Although efforts have been made in order to reduce... 

    Photothermal heating using a near-field plasmonic probe, application in NFO-CVD

    , Article 5th International Conference on Millimeter-Wave and Terahertz Technologies, MMWaTT 2018, 18 December 2018 through 20 December 2018 ; Volume 2018-December , 2019 , Pages 94-96 ; 21570965 (ISSN); 9781538677179 (ISBN) Yazdanfar, P ; Heydarian, H ; Rashidian, B ; Sharif University of Technology
    Institute of Electrical and Electronics Engineers Inc  2019
    Abstract
    We present near-field photothermal heating capability of an aperture SNOM probe by exploiting a bowtie nanostructure on top of the probe aperture, which operates as a nanosource of heat to activate underlying nanoparticle. Heat generation density calculated for the bowtie nanostructure at its absorption resonance wavelength of 694 nm verifies efficient concentration of heating power at the bowtie tips, due to optical near-field effects. Total absorbed power for the nanodisk beneath the probe has the same resonance wavelength at 694 nm, which confirms that the temperature increase produced at the underneath nanoparticle is due to utilizing the bowtie nanostructure on top of the SNOM probe as... 

    Synergistic effect of reduced graphene oxide and carbon black as hybrid light absorber for efficient and antifouling texture-based solar steam generator

    , Article Solar Energy ; Volume 238 , 2022 , Pages 226-237 ; 0038092X (ISSN) Simayee, M ; Iraji zad, A ; Esfandiar, A ; Sharif University of Technology
    Elsevier Ltd  2022
    Abstract
    Efficient utilization of solar energy as the cleanest and most plentiful natural resource for drinking water is a water is as sustianble and environmental friendly approach to obviate long-standing water scarcity. Carbon-based photothermal absorbers due to broadband light absorption are very interesting in interfacial solar steam generation systems. Herein, we investigate the convenient application of reduced graphene oxide (rGO) nanosheets with carbon black (CB) nanoparticles on the cotton fabric as a flexible texture-based photothermal absorber. Polyurethane (PU) as a self-floating insulator foam was selected to manage the energy loss and preserve light converted to heat on the fabric... 

    Photothermally heated and mesh-gridded solar-driven direct contact membrane distillation for high saline water desalination

    , Article International Journal of Heat and Mass Transfer ; Volume 199 , 2022 ; 00179310 (ISSN) Shokrollahi, M ; Asadollahi, M ; Mousavi, S.A ; Rajabi ghahnavieh, A ; Behzadi Sarok, M ; Khayet, M ; Sharif University of Technology
    Elsevier Ltd  2022
    Abstract
    Photothermally heated and mesh-gridded membrane distillation (PHMD) system is proposed for desalination of high saline aqueous solutions. A triple-layered membrane, composed of a photothermal top nanofibrous layer containing polyacrylonitrile and dispersed carbon black nanoparticles and a polyvinylidene fluoride porous membrane supported on a nonwoven polyester, was prepared. A polypropylene mesh was used to hold the membrane. A 3D numerical simulation of the PHMD system was carried out by COMSOL and the appropriate length of the membrane module was determined. The effects of various operating parameters including solar radiation intensity on the permeate flux and thermal efficiency were... 

    Photothermal properties of two-dimensional molybdenum disulfide (MoS2) with nanoflower and nanosheet morphology

    , Article Materials Research Bulletin ; Volume 152 , 2022 ; 00255408 (ISSN) Salimi, M ; Shokrgozar, M. A ; Hamid, D. H ; Vossoughi, M ; Sharif University of Technology
    Elsevier Ltd  2022
    Abstract
    PEGylated MoS2 nanoflower (MoS2-NF) and nanosheet (MoS2-NS) are synthesized through a one-pot hydrothermal method as photo absorbing agent (PAA). It is found that employing different thiol precursors result in distinct morphologies. The products are structurally, chemically, and morphologically characterized. Electron microscopy demonstrates the formation of sheet and flower morphologies of MoS2. Fourier transform infrared (FTIR) and thermal gravimetric (TGA) analysis confirm the PEGylation of MoS2 nanostructures. Raman and X-ray photoelectron spectroscopy (XPS) confirm the formation of 1T/2H structure of both samples. MoS2-NS demonstrates higher NIR absorption than MoS2-NF with a mass... 

    Nanomaterials for photothermal and photodynamic cancer therapy

    , Article Applied Physics Reviews ; Volume 9, Issue 1 , 2022 ; 19319401 (ISSN) Nasseri, B ; Alizadeh, E ; Bani, F ; Davaran, S ; Akbarzadeh, A ; Rabiee, N ; Bahadori, A ; Ziaei, M ; Bagherzadeh, M ; Saeb, M. R ; Mozafari, M ; Hamblin, M. R ; Sharif University of Technology
    American Institute of Physics Inc  2022
    Abstract
    In recent years, the role of optically sensitive nanomaterials has become powerful moieties in therapeutic techniques and has become particularly emphasized. Currently, by the extraordinary development of nanomaterials in different fields of medicine, they have found new applications. Phototherapy modalities, such as photothermal therapy (PTT) by toxic heat generation and photodynamic therapy (PDT) by reactive oxygen species, are known as promising phototherapeutic techniques, which can overcome the limitations of conventional protocols. Moreover, nanomaterial-based PDT and PTT match the simultaneous immune therapy and increase the immune system stimulation resulting from the denaturation of... 

    Nanomedicine and advanced technologies for burns: Preventing infection and facilitating wound healing

    , Article Advanced Drug Delivery Reviews ; Volume 123 , 2018 , Pages 33-64 ; 0169409X (ISSN) Mofazzal Jahromi, M. A ; Sahandi Zangabad, P ; Moosavi Basri, S. M ; Sahandi Zangabad, K ; Ghamarypour, A ; Aref, A. R ; Karimi, M ; Hamblin, M. R ; Sharif University of Technology
    Elsevier B.V  2018
    Abstract
    According to the latest report from the World Health Organization, an estimated 265,000 deaths still occur every year as a direct result of burn injuries. A widespread range of these deaths induced by burn wound happens in low- and middle-income countries, where survivors face a lifetime of morbidity. Most of the deaths occur due to infections when a high percentage of the external regions of the body area is affected. Microbial nutrient availability, skin barrier disruption, and vascular supply destruction in burn injuries as well as systemic immunosuppression are important parameters that cause burns to be susceptible to infections. Topical antimicrobials and dressings are generally... 

    Graphene: Promises, facts, opportunities, and challenges in nanomedicine

    , Article Chemical Reviews ; Volume 113, Issue 5 , 2013 , Pages 3407-3424 ; 00092665 (ISSN) Mao, H. Y ; Laurent, S ; Chen, W ; Akhavan, O ; Imani, M ; Ashkarran, A. A ; Mahmoudi, M ; Sharif University of Technology
    2013
    Abstract
    Graphene, a two-dimensional (2D) sheet of sp2-hybridized carbon atoms packed into a honeycomb lattice, has led to an explosion of interest in the field of materials science, physics, chemistry, and biotechnology since the few-layers graphene (FLG) flakes were isolated from graphite in 2004. For an extended search, derivatives of nanomedicine such as biosensing, biomedical, antibacterial, diagnosis, cancer and photothermal therapy, drug delivery, stem cell, tissue engineering, imaging, protein interaction, DNA, RNA, toxicity, and so on were also added. Since carbon nanotubes are normally described as rolled-up cylinders of graphene sheets and the controllable synthesis of nanotubes is well... 

    Inorganic nanomaterials for chemo/photothermal therapy: a promising horizon on effective cancer treatment

    , Article Biophysical Reviews ; Volume 11, Issue 3 , 2019 , Pages 335-352 ; 18672450 (ISSN) Khafaji, M ; Zamani, M ; Golizadeh, M ; Bavi, O ; Sharif University of Technology
    Springer Verlag  2019
    Abstract
    During the last few decades, nanotechnology has established many essential applications in the biomedical field and in particular for cancer therapy. Not only can nanodelivery systems address the shortcomings of conventional chemotherapy such as limited stability, non-specific biodistribution and targeting, poor water solubility, low therapeutic indices, and severe toxic side effects, but some of them can also provide simultaneous combination of therapies and diagnostics. Among the various therapies, the combination of chemo- and photothermal therapy (CT-PTT) has demonstrated synergistic therapeutic efficacies with minimal side effects in several preclinical studies. In this regard,... 

    Doxorubicin/cisplatin-loaded superparamagnetic nanoparticles as a stimuli-responsive Co-delivery system for chemo-photothermal therapy

    , Article International Journal of Nanomedicine ; Volume 14 , 2019 , Pages 8769-8786 ; 11769114 (ISSN) Khafaji, M ; Zamani, M ; Vossoughi, M ; Iraji zad, A ; Sharif University of Technology
    Dove Medical Press Ltd  2019
    Abstract
    Introduction: To date, numerous iron-based nanostructures have been designed for cancer therapy applications. Although some of them were promising for clinical applications, few efforts have been made to maximize the therapeutic index of these carriers. Herein, PEGylated silica-coated iron oxide nanoparticles (PS-IONs) were introduced as multipurpose stimuli-responsive co-delivery nanocarriers for a combination of dual-drug chemotherapy and photothermal therapy. Methods: Superparamagnetic iron oxide nanoparticles were synthesized via the sonochemical method and coated by a thin layer of silica. The nanostructures were then further modified with a layer of di-carboxylate polyethylene glycol... 

    Doxorubicin/cisplatin-loaded superparamagnetic nanoparticles as a stimuli-responsive Co-delivery system for chemo-photothermal therapy

    , Article International Journal of Nanomedicine ; Volume 14 , 2019 , Pages 8769-8786 ; 11769114 (ISSN) Khafaji, M ; Zamani, M ; Vossoughi, M ; Iraji zad, A ; Sharif University of Technology
    Dove Medical Press Ltd  2019
    Abstract
    Introduction: To date, numerous iron-based nanostructures have been designed for cancer therapy applications. Although some of them were promising for clinical applications, few efforts have been made to maximize the therapeutic index of these carriers. Herein, PEGylated silica-coated iron oxide nanoparticles (PS-IONs) were introduced as multipurpose stimuli-responsive co-delivery nanocarriers for a combination of dual-drug chemotherapy and photothermal therapy. Methods: Superparamagnetic iron oxide nanoparticles were synthesized via the sonochemical method and coated by a thin layer of silica. The nanostructures were then further modified with a layer of di-carboxylate polyethylene glycol... 

    Gold-based hybrid nanostructures: more than just a pretty face for combinational cancer therapy

    , Article Biophysical Reviews ; Volume 14, Issue 1 , 2022 , Pages 317-326 ; 18672450 (ISSN) Khafaji, M ; Bavi, O ; Zamani, M ; Sharif University of Technology
    Springer Science and Business Media Deutschland GmbH  2022
    Abstract
    The early diagnosis together with an efficient therapy of cancer is essential to treat cancer patients and to enhance their quality of life. The use of nanostructures, as a newer technology, has demonstrated proven benefits as efficient cancer theranostic agents in numerous recent studies. Having a tunable surface plasmon resonance, gold nanostructures have been the subject of many recent studies as excellent imaging and photothermal therapy agents. However, the potential cytotoxicity and weak stability of gold nanostructures necessitate further modifications using biocompatible materials for biological applications. Based on the composition of the final structure, these gold-based hybrid... 

    Smart nanostructures for cargo delivery: uncaging and activating by light

    , Article Journal of the American Chemical Society ; Volume 139, Issue 13 , 2017 , Pages 4584-4610 ; 00027863 (ISSN) Karimi, M ; Sahandi Zangabad, P ; Baghaee Ravari, S ; Ghazadeh, M ; Mirshekari, H ; Hamblin, M. R ; Sharif University of Technology
    Abstract
    Nanotechnology has begun to play a remarkable role in various fields of science and technology. In biomedical applications, nanoparticles have opened new horizons, especially for biosensing, targeted delivery of therapeutics, and so forth. Among drug delivery systems (DDSs), smart nanocarriers that respond to specific stimuli in their environment represent a growing field. Nanoplatforms that can be activated by an external application of light can be used for a wide variety of photoactivated therapies, especially light-triggered DDSs, relying on photoisomerization, photo-cross-linking/un-cross-linking, photoreduction, and so forth. In addition, light activation has potential in photodynamic... 

    Graphene/Cuo2nanoshuttles with controllable release of oxygen nanobubbles promoting interruption of bacterial respiration

    , Article ACS Applied Materials and Interfaces ; Volume 12, Issue 32 , 2020 , Pages 35813-35825 Jannesari, M ; Akhavan, O ; Madaah Hosseini, H. R ; Bakhshi, B ; Sharif University of Technology
    American Chemical Society  2020
    Abstract
    An oxygen nanoshuttle based on a reduced graphene oxide/copper peroxide (rGO/CuO2) nanocomposite has been presented to deliver in situ oxygen nanobubbles (O2 NBs) for combating bacterial infections. In the presence of rGO, the solid source of oxygen (i.e., CuO2) was decomposed (in response to environmental conditions such as pH and temperature) into O2 NBs in a more controllable and long-lasting trend (from 60 to 144 h). In a neutral buffer, the O2 NBs experienced growth and collapse evolutions, creating a dynamic micro-nanoenvironment around the nanocomposite. In addition to effective battling against methicillin-resistant Staphylococcus aureus bacteria, the O2 NBs demonstrated superior... 

    Gold nanorods for drug and gene delivery: An overview of recent advancements

    , Article Pharmaceutics ; Volume 14, Issue 3 , 2022 ; 19994923 (ISSN) Jahangiri Manesh, A ; Mousazadeh, M ; Taji, S ; Bahmani, A ; Zarepour, A ; Zarrabi, A ; Sharifi, E ; Azimzadeh, M ; Sharif University of Technology
    MDPI  2022
    Abstract
    Over the past few decades, gold nanomaterials have shown great promise in the field of nanotechnology, especially in medical and biological applications. They have become the most used nanomaterials in those fields due to their several advantageous. However, rod-shaped gold nanoparticles, or gold nanorods (GNRs), have some more unique physical, optical, and chemical properties, making them proper candidates for biomedical applications including drug/gene delivery, photothermal/photodynamic therapy, and theranostics. Most of their therapeutic applications are based on their ability for tunable heat generation upon exposure to near-infrared (NIR) radiation, which is helpful in both... 

    Hyperthermia-induced protein corona improves the therapeutic effects of zinc ferrite spinel-graphene sheets against cancer

    , Article RSC Advances ; Vol. 4, issue. 107 , 2014 , p. 62557-62565 Hajipour, M. J ; Akhavan, O ; Meidanchi, A ; Laurent, S ; Mahmoudi, M ; Sharif University of Technology
    Abstract
    Superparamagnetic zinc ferrite spinel-graphene nanostructures were synthesized as potential therapeutic agents in the magnetic targeted photothermal therapy of cancer and/or drug delivery. The global temperature of the solution and the local temperature at the nanoparticle (NP) surface determine the protein corona composition/content, which in turn affects the biological effects of NPs and the corresponding physiological responses. Therefore, it is rational to hypothesize that spinel-graphene nanostructures may have distinct protein corona compositions and contents, and therapeutic and toxic effects under laser irradiation. To assess this hypothesis, the effects of laser irradiation on the...