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Point-of-use rapid detection of sars-cov-2: Nanotechnology-enabled solutions for the covid-19 pandemic
, Article International Journal of Molecular Sciences ; Volume 21, Issue 14 , 2020 , Pages 1-23 ; Bagherzadeh, M ; Ghasemi, A ; Zare, H ; Ahmadi, S ; Fatahi, Y ; Dinarvand, R ; Rabiee, M ; Ramakrishna, S ; Shokouhimehr, M ; Varma, R. S ; Sharif University of Technology
MDPI AG
2020
Abstract
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) caused the COVID-19 pandemic that has been spreading around the world since December 2019. More than 10 million affected cases and more than half a million deaths have been reported so far, while no vaccine is yet available as a treatment. Considering the global healthcare urgency, several techniques, including whole genome sequencing and computed tomography imaging have been employed for diagnosing infected people. Considerable efforts are also directed at detecting and preventing different modes of community transmission. Among them is the rapid detection of virus presence on different surfaces with which people may come in...
Nanotechnology-assisted microfluidic systems: From bench to bedside
, Article Nanomedicine ; Volume 16, Issue 3 , 2021 , Pages 237-258 ; 17435889 (ISSN) ; Ahmadi, S ; Fatahi, Y ; Rabiee, M ; Bagherzadeh, M ; Dinarvand, R ; Bagheri, B ; Zarrintaj, P ; Saeb, M. R ; Webster, T. J ; Sharif University of Technology
Future Medicine Ltd
2021
Abstract
With significant advancements in research technologies, and an increasing global population, microfluidic and nanofluidic systems (such as point-of-care, lab-on-a-chip, organ-on-a-chip, etc) have started to revolutionize medicine. Devices that combine micron and nanotechnologies have increased sensitivity, precision and versatility for numerous medical applications. However, while there has been extensive research on microfluidic and nanofluidic systems, very few have experienced wide-spread commercialization which is puzzling and deserves our collective attention. For the above reasons, in this article, we review research advances that combine micro and nanotechnologies to create the next...
Label-free electrochemical microfluidic biosensors: futuristic point-of-care analytical devices for monitoring diseases
, Article Microchimica Acta ; Volume 189, Issue 7 , 2022 ; 00263672 (ISSN) ; Samadi Pakchin, P ; Shamloo, A ; Mota, A ; de la Guardia, M ; Omidian, H ; Omidi, Y ; Sharif University of Technology
Springer
2022
Abstract
The integration of microfluidics with electrochemical analysis has resulted in the development of single miniaturized detection systems, which allows the precise control of sample volume with multianalyte detection capability in a cost- and time-effective manner. Microfluidic electrochemical sensing devices (MESDs) can potentially serve as precise sensing and monitoring systems for the detection of molecular markers in various detrimental diseases. MESDs offer several advantages, including (i) automated sample preparation and detection, (ii) low sample and reagent requirement, (iii) detection of multianalyte in a single run, (iv) multiplex analysis in a single integrated device, and (v)...