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    Direction-dependency of the kinematic indices in upper extremities motor assessment of stroke patients

    , Article Medical Engineering and Physics ; Volume 108 , 2022 ; 13504533 (ISSN) Hajihosseinali, M ; Behzadipour, S ; Taghizadeh, G ; Farahmand, F ; Sharif University of Technology
    Elsevier Ltd  2022
    Background: Kinematic indices (KIs) are frequently used as objective measures to assess the upper extremities motor performance in post stroke patients. The clinimetric analysis of these indices has been mostly limited to their averaged values over different directions of reaching movements. Recent studies indicate direction dependencies of such motor performances due to neural and/or biomechanical causes. The direction dependencies of such indices and their clinimetric parameters remains to be investigated. Methods: An apparatus was built to perform and measure planar point-to-point reaching tasks in 8 directions using a virtual reality environment. 24 stroke and 18 healthy individuals... 

    Toward visual chiral recognition of amino acids using a wide-range color tonality ratiometric nanoprobe

    , Article Analytica Chimica Acta ; Volume 1231 , 2022 ; 00032670 (ISSN) Jafar Nezhad Ivrigh, Z ; Fahimi Kashani, N ; Morad, R ; Jamshidi, Z ; Hormozi Nezhad, M. R ; Sharif University of Technology
    Elsevier B.V  2022
    Chiral recognition has long been a challenging issue to deal with in biological systems, drug design and food authentication. Implementing nanoparticle-based probes with intrinsic or induced chirality in this field has addressed several issues concerning sensitivity, reliability, rapidness and the cost of chiral sensing platforms. Yet, research into chiral nanoprobes that can be used for visual monitoring of chiral substances is still in its infancy. As part of this study, a visual chiral recognition platform has been developed in which a combination of blue-emitting carbon dots (BCDs) and mercaptopropionic acid-capped CdTe quantum dots (MPA-QDs) with inherent chiroptical activity were... 

    Recent approaches to mRNA vaccine delivery by lipid-based vectors prepared by continuous-flow microfluidic devices

    , Article Future medicinal chemistry ; Volume 14, Issue 21 , 2022 , Pages 1561-1581 ; 17568927 (ISSN) Ghasemi Toudeshkchouei, M ; Tavakoli, A ; Mohammadghasemi, H ; Karimi, A ; Ai, J ; Rabiee, M ; Rabiee, N ; Sharif University of Technology
    NLM (Medline)  2022
    Advancements in nanotechnology have resulted in the introduction of several nonviral delivery vectors for the nontoxic, efficient delivery of encapsulated mRNA-based vaccines. Lipid- and polymer-based nanoparticles (NP) have proven to be the most potent delivery systems, providing increased delivery efficiency and protection of mRNA molecules from degradation. Here, the authors provide an overview of the recent studies carried out using lipid NPs and their functionalized forms, polymeric and lipid-polymer hybrid nanocarriers utilized mainly for the encapsulation of mRNAs for gene and immune therapeutic applications. A microfluidic system as a prevalent methodology for the preparation of NPs... 

    Clinical validation of a smartphone-based handheld ECG device: A validation study

    , Article Critical Pathways in Cardiology ; Volume 21, Issue 4 , 2022 , Pages 165-171 ; 1535282X (ISSN) Ahmadi-Renani, S ; Gharebaghi, M ; Kamalian, E ; Hajghassem, H ; Ghanbari, A ; Karimi, A ; Mansoury, B ; Dayari, M. S ; Khatmi Nemati, M ; Karimi, A ; Zarghami, M. H ; Vasheghani Farahani, A ; Sharif University of Technology
    Lippincott Williams and Wilkins  2022
    Background: Remote cardiac monitoring and screening have already become an integral telemedicine component. The wide usage of several different wireless electrocardiography (ECG) devices warrants a validation study on their accuracy and reliability. Methods: Totally, 300 inpatients with the Nabz Hooshmand-1 handheld ECG device and the GE MAC 1200 ECG system (as the reference) were studied to check the accuracy of the devices in 1 and 6-limb lead performance. Simultaneous 10-second resting ECGs were assessed for the most common ECG parameters in lead I. Afterward, 6-lead ECGs (limb leads), were performed immediately and studied for their morphologies. Results: Of the 300 patients, 297 had... 

    Deep learning for caries detection: A systematic review

    , Article Journal of Dentistry ; Volume 122 , 2022 ; 03005712 (ISSN) Mohammad Rahimi, H ; Motamedian, S. R ; Rohban, M. H ; Krois, J ; Uribe, S. E ; Mahmoudinia, E ; Rokhshad, R ; Nadimi, M ; Schwendicke, F ; Sharif University of Technology
    Elsevier Ltd  2022
    Objectives: Detecting caries lesions is challenging for dentists, and deep learning models may help practitioners to increase accuracy and reliability. We aimed to systematically review deep learning studies on caries detection. Data: We selected diagnostic accuracy studies that used deep learning models on dental imagery (including radiographs, photographs, optical coherence tomography images, near-infrared light transillumination images). The latest version of the quality assessment tool for diagnostic accuracy studies (QUADAS-2) tool was used for risk of bias assessment. Meta-analysis was not performed due to heterogeneity in the studies methods and their performance measurements.... 

    An integrative method to increase the reliability of conventional double emulsion method

    , Article Analytica Chimica Acta ; Volume 1197 , 2022 ; 00032670 (ISSN) Mashhadian, A ; Afjoul, H ; Shamloo, A ; Sharif University of Technology
    Elsevier B.V  2022
    Polymeric microspheres which can load biomolecules, cells and active agents play an important role in tissue engineering and drug delivery systems. The conventional double emulsion method has been frequently used to fabricate polymeric microspheres. However, this method has two major shortcomings: the complicated fabrication process which makes it difficult to predict the characteristics of the final microspheres while the size distribution of the microspheres has a wide range. In this study, we eliminate the shortcomings of the conventional double emulsion method and increase its performance without decreasing its high production rate. This can make the proposed modified method a promising... 

    Multilayered mesoporous composite nanostructures for highly sensitive label-free quantification of cardiac troponin-i

    , Article Biosensors ; Volume 12, Issue 5 , 2022 ; 20796374 (ISSN) Saeidi, M ; Amidian, M. A ; Sheybanikashani, S ; Mahdavi, H ; Alimohammadi, H ; Syedmoradi, L ; Mohandes, F ; Zarrabi, A ; Tamjid, E ; Omidfar, K ; Simchi, A ; Sharif University of Technology
    MDPI  2022
    Cardiac troponin-I (cTnI) is a well-known biomarker for the diagnosis and control of acute myocardial infarction in clinical practice. To improve the accuracy and reliability of cTnI electrochemical immunosensors, we propose a multilayer nanostructure consisting of Fe3O4-COOH labeled anti-cTnI monoclonal antibody (Fe3O4-COOH-Ab1 ) and anti-cTnI polyclonal antibody (Ab2 ) conjugated on Au-Ag nanoparticles (NPs) decorated on a metal–organic framework (Au-Ag@ZIF-67-Ab2 ). In this design, Fe3O4-COOH was used for separation of cTnI in specimens and signal amplification, hierarchical porous ZIF-67 extremely enhanced the specific surface area, and Au-Ag NPs synergically promoted the conductivity... 

    Application of numerical simulation to solid phase-microextraction for decreasing of extraction time of pyrene and phthalate esters on solid coatings

    , Article Journal of Chromatography A ; Volume 1673 , 2022 ; 00219673 (ISSN) Jafari, M ; Jamshidian, M ; Habibi, S ; Sharif University of Technology
    Elsevier B.V  2022
    Reynolds-Averaged Navier-Stokes (RANS) approach with the k-ε closure model is employed for the first time to simulate direct Solid-Phase Micro-Extraction (SPME) computationally. Simulations are performed by using COMSOL Multiphysics in order to examine methods to decrease the extraction time. Experiments are also conducted to support data obtained from the numerical framework. Di-n-Butyl Phthalate (DNBP) and etched steel wire are chosen as the analyte and the adsorbent, respectively. Stirring rate, fiber's location, stirrer magnet's size, and the method of sample rotation are examined to decrease the extraction time. In addition, the effects of adding a baffle to the vial and implementing a... 

    How resiliency and hope can predict stress of covid-19 by mediating role of spiritual well-being based on machine learning

    , Article Musculoskeletal Science and Practice ; Volume 51 , 2021 ; 24688630 (ISSN) Noorollahzadeh, K ; Kahrizi, S ; Fesharaki, M. G ; Heidarian, M ; Neblett, R ; Behzadipour, S ; Sharif University of Technology
    Elsevier Ltd  2021
    Background: The Central Sensitization Inventory (CSI) is a patient-reported tool to assess symptoms associated with central sensitization (CS). It consists of two parts: Part A assesses 25 somatic and emotional CS-related health symptoms, and part B asks if one has previously been diagnosed with a list of 10 Central Sensitivity Syndromes and related conditions. Objectives: The aim of this study was to translate and cross-culturally adapt the CSI into Persian and to evaluate its psychometric properties. Design: Cross-sectional study. Method: After completing the Persian translation, the psychometric properties of the Persian CSI (CSI-Per) were evaluated in 256 patients with chronic pain and... 

    Nanoscale characterization of the biomolecular corona by cryo-electron microscopy, cryo-electron tomography, and image simulation

    , Article Nature Communications ; Volume 12, Issue 1 , 2021 ; 20411723 (ISSN) Sheibani, S ; Basu, K ; Farnudi, A ; Ashkarran, A ; Ichikawa, M ; Presley, J. F ; Bui, K. H ; Ejtehadi, M. R ; Vali, H ; Mahmoudi, M ; Sharif University of Technology
    Nature Research  2021
    The biological identity of nanoparticles (NPs) is established by their interactions with a wide range of biomolecules around their surfaces after exposure to biological media. Understanding the true nature of the biomolecular corona (BC) in its native state is, therefore, essential for its safe and efficient application in clinical settings. The fundamental challenge is to visualize the biomolecules within the corona and their relationship/association to the surface of the NPs. Using a synergistic application of cryo-electron microscopy, cryo-electron tomography, and three-dimensional reconstruction, we revealed the unique morphological details of the biomolecules and their... 

    Preparation of amine–modified lignin and its applicability toward online micro–solid phase extraction of valsartan and losartan in urine samples

    , Article Journal of Chromatography A ; Volume 1643 , 2021 ; 00219673 (ISSN) Taherzadeh Ghahfarrokhi, M ; Zeinali, S ; Bagheri, H ; Sharif University of Technology
    Elsevier B.V  2021
    In the present work, with the focus on an environmentally–friendly approach, some gels were prepared by synthesizing amine–modified lignin, extracted from sugarcane bagasse, and further esterification and subsequent freeze–drying. These lignin–based gels were implemented as extractive phases in an online micro–solid phase extraction (μSPE) setup in conjunction with high performance liquid chromatography (HPLC) with UV detector. The developed method was used for analytical determination of valsartan and losartan in urine samples. To study the effect of the functionalization process, the efficiency of the unmodified lignin and the functionalized lignin were compared both in the absence and the... 

    A part-level learning strategy for JPEG image recompression detection

    , Article Multimedia Tools and Applications ; Volume 80, Issue 8 , 2021 , Pages 12235-12247 ; 13807501 (ISSN) Taimori, A ; Razzazi, F ; Behrad, A ; Ahmadi, A ; Babaie Zadeh, M ; Sharif University of Technology
    Springer  2021
    Recompression is a prevalent form of multimedia content manipulation. Different approaches have been developed to detect this kind of alteration for digital images of well-known JPEG format. However, they are either limited in performance or complex. These problems may arise from different quality level options of JPEG compression standard and their combinations after recompression. Inspired from semantic and perceptual analyses, in this paper, we suggest a part-level middle-out learning strategy to detect double compression via an architecturally efficient classifier. We first demonstrate that singly and doubly compressed data with different JPEG coder settings lie in a feature space... 

    How do adsorbent orientation and direction of external electric field affect the charge-transfer surface-enhanced raman spectra?

    , Article Journal of Physical Chemistry C ; Volume 125, Issue 24 , 2021 , Pages 13382-13390 ; 19327447 (ISSN) Ashtari Jafari, S ; Jamshidi, Z ; Sharif University of Technology
    American Chemical Society  2021
    Surface-enhanced Raman spectroscopy is a highly sensitive phenomenon and a powerful fingerprint detection tool that reflects the small changes in polarizability on the pattern and intensity of Raman signals. The SERS enhancement signals elucidate with the surface-selection rules. In this regard, molecular configuration and adsorption orientation on the surface, in addition to the direction of external electric field, can lead to different patterns of SERS spectra. To evaluate how the variation of these features influences the pattern and reproducibility of the spectra, the chemical charge-transfer SERS spectra for pyridine on silver clusters are calculated for different field directions,... 

    Objective measurement of inferior-directed stiffness in glenohumeral joint using a specially designed robotic device in healthy shoulders; within- and between-session reliability

    , Article Journal of Biomechanics ; Volume 127 , 2021 ; 00219290 (ISSN) Azarsa, M. H ; Mirbagheri, A. R ; Hosseini, R ; Shadmehr, A ; Karimi, N ; Sharif University of Technology
    Elsevier Ltd  2021
    Clinical assessment of capsuloligamentous structures of the glenohumeral joint has been qualitative and subjective in nature, as demonstrated by limited intra- and inter-rater reliability. Robotic devices were utilized to develop a clinically objective measurement technique for glenohumeral joint stiffness. The purpose of this study was to quantify the amount of inferior-direction stiffness of the glenohumeral joint using a safe clinical device in the asymptomatic individuals, and to determine between trial and between session reliability of the robotic device. Twenty healthy subjects were recruited via convenience sampling. Inferior-directed translation and applying force were measured... 

    A multi-scale model for determining the effects of pathophysiology and metabolic disorders on tumor growth

    , Article Scientific Reports ; Volume 10, Issue 1 , 20 February , 2020 Nikmaneshi, M. R ; Firoozabadi, B ; Mozafari, A ; Munn, L. L ; Sharif University of Technology
    Nature Research  2020
    The search for efficient chemotherapy drugs and other anti-cancer treatments would benefit from a deeper understanding of the tumor microenvironment (TME) and its role in tumor progression. Because in vivo experimental methods are unable to isolate or control individual factors of the TME and in vitro models often do not include all the contributing factors, some questions are best addressed with systems biology mathematical models. In this work, we present a new fully-coupled, agent-based, multi-scale mathematical model of tumor growth, angiogenesis and metabolism that includes important aspects of the TME spanning subcellular-, cellular- and tissue-level scales. The mathematical model is... 

    Roles of metal, ligand and post synthetic modification on metal organic frameworks to extend their hydrophobicity and applicability toward ultra–trace determination of priority organic pollutants

    , Article Analytica Chimica Acta ; Volume 1125 , 2020 , Pages 231-246 Javanmardi, H ; Abbasi, A ; Bagheri, H ; Sharif University of Technology
    Elsevier B.V  2020
    Implementation of metal organic frameworks (MOFs) in the separation science has attracted many researchers attention. In this study, the role of metal, ligand, the reaction condition and modification on the extraction efficiency of some MOFs was investigated. Among the prevalent reported MOFs, some members of the MIL and MOF–5 families were chosen, and eleven MOF–based sorbents were prepared by changing the metal and ligand type, reaction condition, and/or functionality through post synthetic modification (PSM). MIL–101 and MIL–101–NH2 based structures were initially synthesized based on the chromium and iron salts. Also, three zinc–based structures including MOF–5, [NH2(CH3)2]2... 

    The geometrical characteristics of nickel-based metal organic framework on its entrapment capability

    , Article Journal of Chromatography A ; Volume 1610 , 2020 Javanmardi, H ; Abbasi, A ; Bagheri, H ; Sharif University of Technology
    Elsevier B.V  2020
    Here, a three dimensional nickel–based metal organic framework (MOF) was synthesized via solvothermal and room temperature protocols. In order to study the effects of the synthesis conditions on the physical properties such as pore sizes and shapes of the prepared MOFs, their extraction capabilities were examined. Both MOFs were characterized by Fourier transform infrared spectroscopy, powder X-ray diffraction, scanning electron microscopy, Brunauer–Emmett–Teller and thermogravimetric analyses. Brilliant properties such as porous structure, high surface area and considerable thermal stability make them reasonable candidates to be employed as efficient extractive phases. The efficiency of the... 

    Single-replicate longitudinal data analysis in the presence of multiple instrumental measurement errors

    , Article Computers and Industrial Engineering ; Volume 141 , 2020 Moazeni, M ; Behbahani, M ; Khedmati, M ; Akhavan Niaki, S. T ; Sharif University of Technology
    Elsevier Ltd  2020
    In this paper, a novel method as a combination of the expectation–maximization (EM) algorithm and Variogram is proposed to decompose the longitudinal measurement errors in the absence of replications and the presence of multiple instrumental measurement errors. In the proposed method, multiple measurements are considered where the units are observed by several distinct instruments (gauges). The approach decouples the observed variance of the measurement model into the process and measurement system variances. In addition, it decomposes the variance of multiple instruments into the process and instrument variances. In the end, the proposed model is validated and tested based on simulated... 

    Amine modified magnetic polystyrene for extraction of drugs from urine samples

    , Article Journal of Chromatography A ; Volume 1602 , 2019 , Pages 107-116 ; 00219673 (ISSN) Zeinali, S ; Maleki, M ; Bagheri, H ; Sharif University of Technology
    Elsevier B.V  2019
    Polystyrene is one of the best candidates as the extracting medium due to its high stability in different media and acceptable extraction capability. However, the hydrophobic nature and low wettability of polystyrene limits its application to non–polar analytes. To resolve this limitation, in this project, amine groups were chemically attached to the surface of magnetic polystyrene. The resulting hydrophilic magnetic particles were expected to be capable of extracting both polar and non–polar analytes. Non–steroidal anti–inflammatory drugs (NSAIDs) were chosen for testing the applicability of modified magnetic polystyrene according to the importance of their analysis and also their wide... 

    Generic extraction medium: From highly polar to non-polar simultaneous determination

    , Article Analytica Chimica Acta ; Volume 1066 , 2019 , Pages 1-12 ; 00032670 (ISSN) Zeinali, S ; Khalilzadeh, M ; Bagheri, H ; Sharif University of Technology
    Elsevier B.V  2019
    Sample preparation for non-target analysis is challenging due to the difficulty in the extraction of polar and non-polar analytes simultaneously. Most commercial solid sorbents lack the proper comprehensiveness for extraction of analytes with different physiochemical properties. A possible key is the combination of hydrophobic polymer and hydrophilic surface functional groups in solid based extraction methods in order to generate the susceptibility for retaining both polar and non-polar analytes. To pursue this goal, in this study, four polar groups including [sbnd]NH 2 , [sbnd]NO 2 , [sbnd]COOH, and [sbnd]COCH 3 were chemically bound to Amberlite XAD-4 substrate in order to prepare a...