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Identification of suitable drug combinations for treating covid-19 using a novel machine learning approach: the rain method
, Article Life ; Volume 12, Issue 9 , 2022 ; 20751729 (ISSN) ; Salari, N ; Boush, M ; Mansouri, K ; Hosseinian-Far, A ; Ghasemi, H ; Mohammadi, M ; Sharif University of Technology
MDPI
2022
Abstract
COVID-19 affects several human genes, each with its own p-value. The combination of drugs associated with these genes with small p-values may lead to an estimation of the combined p-value between COVID-19 and some drug combinations, thereby increasing the effectiveness of these combinations in defeating the disease. Based on human genes, we introduced a new machine learning method that offers an effective drug combination with low combined p-values between them and COVID-19. This study follows an improved approach to systematic reviews, called the Systematic Review and Artificial Intelligence Network Meta-Analysis (RAIN), registered within PROSPERO (CRD42021256797), in which, the PRISMA...
A full pipeline of diagnosis and prognosis the risk of chronic diseases using deep learning and Shapley values: The Ravansar county anthropometric cohort study
, Article PLoS ONE ; Volume 17, Issue 1 January , 2022 ; 19326203 (ISSN) ; Shohaimi, S ; Salari, N ; Kiaei, A. A ; Najafi, F ; Khazaei, S ; Niaparast, M ; Abdollahi, A ; Mohammadi, M ; Sharif University of Technology
Public Library of Science
2022
Abstract
Anthropometry is a Greek word that consists of the two words "Anthropo"meaning human species and "metery"meaning measurement. It is a science that deals with the size of the body including the dimensions of different parts, the field of motion and the strength of the muscles of the body. Specific individual dimensions such as heights, widths, depths, distances, environments and curvatures are usually measured. In this article, we investigate the anthropometric characteristics of patients with chronic diseases (diabetes, hypertension, cardiovascular disease, heart attacks and strokes) and find the factors affecting these diseases and the extent of the impact of each to make the necessary...